본문 바로가기
KERD
논문KCI 등재

Oseltamivir를 투약한 양성대조군과 비교한 인플루엔자의 한약 치료 효과 -RCT 연구를 중심으로-

Review of Clinical Research for Herbal Medicine in the Treatment of Influenza Compared with Oseltamivir

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류한의학

초록

Objectives: The purpose of this study is to analyze clinical studies on effectiveness of herbal medicine in influenza compared with Oseltamivir. Methods: We searched the randomized controlled trials (RCTs) with herbal medicine treatment on influenza compared to Oseltamivir from the Pubmed, CNKI, OASIS, NDSL, J-stage, and CiNii. Results: 14 out of 717 studies were selected and analyzed. The herbal medicine treatment had a significant effects on the alleviation of fever, cough, sore throat than the Oseltamivir control treatment. Herbal medicine had same therapeutic effectiveness like Oseltamivir on duration of influenza-like symptoms and viral shedding. No serious adverse reactions were reported from the herbal medicine treatment. Conclusions: The results of these trials showed that the herbal medicine may be more effective than the Oseltamivir in the treatment of influenza. Well-designed RCTs for domestic herbal medicine treatment on influenza are needed to prove its efficacy clearly.

Abstract

Objectives: The purpose of this study is to analyze clinical studies on effectiveness of herbal medicine in influenza compared with Oseltamivir. Methods: We searched the randomized controlled trials (RCTs) with herbal medicine treatment on influenza compared to Oseltamivir from the Pubmed, CNKI, OASIS, NDSL, J-stage, and CiNii. Results: 14 out of 717 studies were selected and analyzed. The herbal medicine treatment had a significant effects on the alleviation of fever, cough, sore throat than the Oseltamivir control treatment. Herbal medicine had same therapeutic effectiveness like Oseltamivir on duration of influenza-like symptoms and viral shedding. No serious adverse reactions were reported from the herbal medicine treatment. Conclusions: The results of these trials showed that the herbal medicine may be more effective than the Oseltamivir in the treatment of influenza. Well-designed RCTs for domestic herbal medicine treatment on influenza are needed to prove its efficacy clearly.

참고문헌 (41)

  1. Korean Association for the Study of Infectious Diseases, "Infectious diseases" (2014), Koonja
  2. "Influenza(Seasonal)" (2019)[URL]
  3. Paules C, "Influenza", Lancet, 390(10095), pp.697~708 (2017)
  4. 김성균, "Occurrence and characterization of oseltamivirresistant influenza virus in children between 2007-2008 and 2008-2009 seasons", Clinical and Experimental Pediatrics, 56(4), pp.165~175 (2013), 대한소아청소년과학회
  5. Jefferson T, "Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children", Cochrane Database Syst Rev, 2014(4), pp.CD008965~ (2014)
  6. Heneghan CJ, "Neuraminidase inhibitors for influenza : a systematic review and metaanalysis of regulatory and mortality data", Health Technol Assess, 20(42), pp.1~242 (2016)
  7. Whitley RJ, "Oral Oseltamivir treatment of influenza in children", Pediatr Infect Dis, 20(2), pp.127~133 (2001)
  8. Heinonen S, "Early Oseltamivir treatment of influenza in children 1-3 years of age : a randomized controlled trial", Clin Infect Dis, 51(8), pp.887~894 (2010)
  9. Jiang L, "Chinese medicinal herbs for influenza", Cochrane Database Syst Rev, (3), pp.CD004559~ (2013)
  10. Yoshino T, "The use of maoto(Ma-huang-tang), a traditional Japanese Kampo medicine, to alleviate flu symptoms : a systematic review and meta-analysis", BMC Complemt Alter Med, 19(1), pp.19~68 (2019)
  11. Lee JY, "Herbal medicines with antiviral activity against the influenza virus, a systematic review", J Am Chin Med, 46(8), pp.1663~1700 (2017)
  12. Niu Q, "Efficacy and safety of lianhua qingwen capsule for influenza : a systemic review", J Chin Med, 42(8), pp.1472~1481 (2017)
  13. 전현진, "소음인 A형 인플루엔자 감염 치험례", 사상체질의학회지, 30(2), pp.55~63 (2018), 사상체질의학회[DOI]
  14. 선승호, "2009년 유행 신종인플루엔자 A(H1N1)의 한약 및 기타 비전형적 치료에 대한 고찰", 대한한방내과학회지, 30(3), pp.558~570 (2009), 대한한방내과학회
  15. Kubo T, "Antipyretic effect of mao-to, a japanese herbal medicine, for treatment of type a influenza infection in children", Phytomedicine, 14(2-3), pp.96~101 (2007)
  16. Liu G, "The randomized controlled study of lianhuaqingwen capsule in treating A(H1N1)influenza", Chin J Diffic and Comp Cas, 9(1), pp.14~16 (2010)
  17. Chen H, "The stochastically control investigation of oseltamivir and chinese traditional medicine in treating influenza A(H1N1)", J Sichuan med, 31(8), pp.1050~1052 (2010)
  18. Su YH, "A clinical research of chaigejiejitang treating the influenza A (H1N1)", Master's, pp.2010
  19. Tan X, "Clinical study of integrated chinese-western therapy for new-type swine-origin influenza A", J Guangzhou Univ Tradit Chin Med, 27(5), pp.441~444 (2010)
  20. Dou A, "Curative effect observation of Tamiflu and traditional Chinese medicine on type A H1N1 influenza", J Integre Tradit West med, 19(26), pp.3289~3290 (2010)
  21. Duan Z, "Natural herbal medicine Lianhuaqingwen capsule anti-influenza A(H1N1)trial : a randomized, double blind, positive controlled clinical trial", Chin Med J, 124(18), pp.2925~2933 (2011)
  22. Wang C, "Oseltamivir compared with the chinese traditional therapy maxingshigan–yinqiaosan in the treatment of H1N1 influenza", Ann intern med, 155(4), pp.217~225 (2011)
  23. Nabeshima S, "A randomized, controlled trial comparing traditional herbal medicine and neuraminidase inhibitors in the treatment of seasonal influenza", J Infect Chemother, 18(4), pp.534~543 (2012)
  24. Xiao D, "Clinical observation of tianlong compound on influenza A", J Chin Exp Tradit Med, 20(4), pp.171~174 (2014)
  25. Hong Y, "The study of observing the effect of hang huo anti-influenza decoction in the treatment of influenza in lingnan district", Master's, pp.2016
  26. Geng P, "Application of modified Yinqiao decoction in patients with influenza A virus infection Chninese community doctors", J Pract Tradit Chin Int Med, 33(6), pp.72~73 (2017)
  27. Lian T, "Randomized parallel controlled study on the equivalent of modified Yinqiao decoction in the treatment of influenza a H1N1 influenza virus infection and oseltamivir phosphate", J Pract Tradit Chin Intern Med, 31(10), pp.14~17 (2017)
  28. Zhan F, "Oseltamivir in the treatment of influenza-like illness in children", J Pediatr Pharm, 24(6), pp.28~30 (2018)
  29. Al Johani SM, "validity of two rapid point of care influenza tests and direct fluorecence assay in comparison of real time PCR for swine of origin Influenza virus", J Infect Public Health, 4(1), pp.7~11 (2011)
  30. 최원석, "The Clinical Usefulness of the SD Bioline Influenza Antigen Test^® for Detecting the 2009 Influenza A (H1N1) Virus", Yonsei Medical Journal, 52(4), pp.683~685 (2011), 연세대학교의과대학
  31. Tsao KC, "Performance of rapid-test kits for the detection of the pandemic influenza A", H1N1 virus, 2011, pp.173(2), 387~389
  32. Ge Y, "Detection of novel swine origin influenza A virus(H1N1)by real-time nucleic acid sequence-based amplification", J Virol Methods, 163(2), pp.495~497 (2010)
  33. Hayden FG, "Emerging influenza antiviral resistance threats", J Infect Dis, 203(1), pp.6~10 (2011)
  34. Lee YG, "Special Lecture of Warm (Pathogen) Disease Clinic", pp.15~ (2001), Publication DaeSung UiHakSa
  35. Moon JJ, "ShangHanLunJeongHae", pp.176~182 (2010), Publicaton Han Eui Mun Hwa Sa
  36. Uyeki T, "Antiviral treatment for patients hospitalized with 2009 pandemic influenza A (H1N1)", N Engl J Med, 361(23), pp.e110~ (2009)
  37. Hayden F, "Developing new antiviral agents for influenza treatment: what does the future hold?", Clin Infect Dis, 48(Suppl 1), pp.3~13 (2009)
  38. WHO, "Pandemic (H1N1) 2009 briefing note 1: Viruses resistant to Oseltamivir (Tamiflu) identified", Wkly Epidemiol Rec, 84(29), pp.299~399 (2009)
  39. Wong LY, "A herbal formula for prevention of influenza-like syndrome : a double-blind randomized clinical trial", Chin J Integr Med, 19(4), pp.253~259 (2013)
  40. Ding Y, "The chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function", BMC Complement Alter Med, 17(1), pp.130~ (2017)
  41. Arita R, "National cost estimation of maoto, a kampo medicine, compared with oseltamivir for the treatment of influenza in Japan", Tradit Kampo Med, 3(1), pp.59~62 (2016)

관련 논문AI추천

이 간행물의 다른 논문 (7건)