본문 바로가기
KERD
논문KCI 등재

소아 편도염의 한약 치료에 대한 최신 임상 연구 동향- 중국 RCT 연구를 중심으로 -

Review of Recent Clinical Studies of Herbal Medicine Treatment for Pediatric Tonsillitis – Focused on Chinese Randomized Controlled Trials -

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류한의학

초록

Objectives: The purpose of this study is to investigate recent clinical studies on the effect of herbal medicine for pediatric tonsillitis in China, and to seek better methods to treat and study for pediatric tonsillitis in Republic of Korea. Methods: We searched clinical studies from the China National Knowledge Infrastructure (CNKI) by search formula (SU='扁桃体炎'+'扁桃炎'+'扁桃腺炎'+'乳蛾'+'喉蛾'+'蚕蛾'+'石蛾'+'珠蛾'+'肉蛾'+'乳蛾风'+'烂乳风'+'tonsillitis') and (SU='中药'+'中医药'+'本草'+'汤'+'丸'+'散'+'方'+'颗粒'+'胶囊'+'自拟'+'herb'+'herbal'+'decoction'+'remedy'+'Chinese medicine'+'Korean medicine'+'kampo'+'formula'+'herbal drug'+'Chinese drug'+'plant'+'Chinese prescription'+'traditional medicine'+'Medicine, East Asian Traditional'+'Herbal Medicine') in professional search from January 2016 to August 2020. We analyzed the literature focusing on the treatment methods and results. Results: Among 1464 searched studies, 35 randomized controlled trials were selected and analyzed. In most studies, the effectiveness of oral administration of herbal medicine on pediatric tonsillitis was significant. Most commonly used herbs were Fructus Forsythiae (連翹), Radix Glycyrrhizae (甘草), Radix Scutellariae (黃芩), Herba Menthae (薄荷), Fructus Arctii (牛蒡子), Radix Scrophulariae (玄蔘), Radix Platycodi (桔梗), Flos Lonicerae (金銀花), Radix Isatidis (板藍根), Radix Bupleuri (柴胡), Fructus Gardeniae (梔子), Rhizoma Belamcandae (射干), Radix et Rhizoma Rhei (大黃), Gypsum Fibrosum (石膏). Conclusions: By analyzing the improvement of indicators such as total effective rate, cured rate, symptom disappearance time and symptom score, we found that herbal medicine treatment can help improve pediatric tonsillitis. However, additional studies are needed to solidify these findings.

Abstract

Objectives: The purpose of this study is to investigate recent clinical studies on the effect of herbal medicine for pediatric tonsillitis in China, and to seek better methods to treat and study for pediatric tonsillitis in Republic of Korea. Methods: We searched clinical studies from the China National Knowledge Infrastructure (CNKI) by search formula (SU='扁桃体炎'+'扁桃炎'+'扁桃腺炎'+'乳蛾'+'喉蛾'+'蚕蛾'+'石蛾'+'珠蛾'+'肉蛾'+'乳蛾风'+'烂乳风'+'tonsillitis') and (SU='中药'+'中医药'+'本草'+'汤'+'丸'+'散'+'方'+'颗粒'+'胶囊'+'自拟'+'herb'+'herbal'+'decoction'+'remedy'+'Chinese medicine'+'Korean medicine'+'kampo'+'formula'+'herbal drug'+'Chinese drug'+'plant'+'Chinese prescription'+'traditional medicine'+'Medicine, East Asian Traditional'+'Herbal Medicine') in professional search from January 2016 to August 2020. We analyzed the literature focusing on the treatment methods and results. Results: Among 1464 searched studies, 35 randomized controlled trials were selected and analyzed. In most studies, the effectiveness of oral administration of herbal medicine on pediatric tonsillitis was significant. Most commonly used herbs were Fructus Forsythiae (連翹), Radix Glycyrrhizae (甘草), Radix Scutellariae (黃芩), Herba Menthae (薄荷), Fructus Arctii (牛蒡子), Radix Scrophulariae (玄蔘), Radix Platycodi (桔梗), Flos Lonicerae (金銀花), Radix Isatidis (板藍根), Radix Bupleuri (柴胡), Fructus Gardeniae (梔子), Rhizoma Belamcandae (射干), Radix et Rhizoma Rhei (大黃), Gypsum Fibrosum (石膏). Conclusions: By analyzing the improvement of indicators such as total effective rate, cured rate, symptom disappearance time and symptom score, we found that herbal medicine treatment can help improve pediatric tonsillitis. However, additional studies are needed to solidify these findings.

참고문헌 (75)

  1. Ko WS, "Opthalmology, otolaryngology & dermatology", pp.224~227 (2019), Globooks Publishing Co
  2. Sim MG, "Literature study on tonsillitis in children - comparison between oriental and western medicine", J Pediatr Korean Med, 6(1), pp.81~96 (1992)
  3. Roh SS, "The primary opthalmology & otolaryngology", pp.702~ (2003), Jumin Publishing Co
  4. Baltimore RS, "Re-evaluation of antibiotic treatment of streptococcal pharyngitis", Curr Opin Pediatr, 22(1), pp.77~82 (2010)
  5. Korean Society of Otorhinolaryngology-Head and Neck Surgery, "Otorhinolaryngology-head and neck surgery", pp.317~318 (2018), Goon Ja Publishing Co
  6. 이승준, "음성 후두 질환에 대한 접근 및 치료", Korean Journal of Family Medicine, 28(6), pp.411~420 (2007), 대한가정의학회
  7. "NHISS portal"[URL]
  8. 김홍준, "玄黃解毒湯으로 호전된 급성편도선염 치험 4례", 동의생리병리학회지, 18(1), pp.285~288 (2004), 한의병리학회
  9. 안재현, "급성 편도선염에 의해 촉발된 다형홍반 환자 치험 1례", 한방안이비인후피부과학회지, 28(2), pp.75~84 (2015), 대한한방안이비인후피부과학회[DOI]
  10. 이현우, "자락요법과 고백반 도포로 호전된 급성 편도선염 소아환자의 임상연구", 한방안이비인후피부과학회지, 25(1), pp.75~83 (2012), 대한한방안이비인후피부과학회
  11. Lee JS, "A literature study on tonsillitis in children", J Korean Med, 4(1), pp.65~69 (1983)
  12. Lee SJ, "Oriental and western medical study on tonsillitis in children", J Pediatr Korean Med, 8(1), pp.111~124 (1994)
  13. Lu CF, "Observation on the curative effect of modified Yin Qiao San combined with azithromycin in the treatment of children with acute tonsillitis", J Pract Tradit Chin Med, 36(2), pp.202~203 (2020)
  14. Zhao HB, "Application of Xiao’ehiqiaoqingre granules combined with amoxicillin and clavulanate potassium for suspension in the treatment of children with acute tonsillitis", J Med Theory Pract, 33(11), pp.1834~1835 (2020)
  15. Zhang QJ, "A report of 70 cases of infantile acute tonsillitis treated with Liang Ge San", Electronic J Clin Med Literature, 7(13), pp.173~ (2020)
  16. Yan L, "Qingfei Liyan decoction in the treatment of children with purulent tonsillitis with lung and stomach heat syndrome and its effect on inflammatory factors and T lymphocyte subsets", J Hebei Tradit Chin Med, 42(4), pp.528~532 (2020)
  17. Yang J, "Analysis of clinical effects of Yin Qiao San on children with acute tonsillitis", Renowned Doctor, 4, pp.267~ (2020)
  18. An R, "Effect of Huang Qiao Li Yan decoction and cephalosporin extended-release tablets on acute tonsillitis in children", Chin med Technology, 27(3), pp.458~459 (2020)
  19. Liu SY, "Clinical observation on 30 cases of acute tonsillitis in children with wind-heat syndrome treated by modified Chaige Jieji Tang as adjuvant therapy", J Pediatr Tradit Chin Med, 16(3), pp.45~47 (2020)
  20. Dong SS, "Fifty cases of acute tonsillitis in children with syndrome of external wind-heat invasion treated with Throat-heat-clearing decoction", Henan Tradit Chin Med, 40(6), pp.901~904 (2020)
  21. Duan XZ, "Clinical observation of Jiedu Liyan formula in treating infantile purulent tonsillitis of heat exuberance in lung and stomach", Jilin J Chin Med, 40(2), pp.160~162 (2020)
  22. Ren JD, "Clinical effect observation of New Niu-banggan-jie-tang in the treatment of 41 cases of pediatric rotten tonsillitis", Chin Foreign Med Res, 17(22), pp.140~142 (2019)
  23. Fu YZ, "Effect of modified Niu-bang-gan-jie-tang on acute suppurative tonsillitis in children", Contemp Med Symp, 17(23), pp.171~172 (2019)
  24. Ma QH, "Effect analysis of treating children acute tonsillitis with Xiaoshiqiao qingregranule", Chin Med Dig (Otolaryngol), 2, pp.94~96 (2019)
  25. Gan N, "Observation on efficacy of Shufengjiedu capsules in treatment of acute tonsillitis in children", J Emerg Tradit Chin Med, 28(8), pp.1477~1479 (2019)
  26. Huang WQ, "Clinical observation on the treatment of external cold and internal heat type of acute suppurative tonsillitis in children with Poai decoction", Tradit Chin Med J, 17(6), pp.61~63 (2018)
  27. Huang GH, "Application of amoxicillin and clavulanate potassium and Qingre Jiedu capsules in children with tonsillitis", The Med Forum, 22(20), pp.2777~2778 (2018)
  28. He ZQ, "Clinical observation of modified Liang Ge powder on pediatric acute suppurative tonsillitis of lung-stomach heat pattern", Master, pp.2018
  29. Zheng XJ, "Observation on curative effect of modified Niu-bang-gan-jie-tang treatment in pediatric rotten tonsillitis", J North Pharm, 15(11), pp.74~75 (2018)
  30. Yao J, "Clinical observation on Rhubarb be taken after being infused in hot water or decoction in the treatment of acute suppurative tonsillitis in children", Chin Community Doctors, 34(34), pp.127~128 (2018)
  31. Yang DX, "Clinical observation of Gan Lu Xiao Du pill combined with Sheng Jiang powder additional prescription in treating acute suppurative tonsillitis with syndrome of damp - heat and amassing poison", Chin J Ethnomed Ethnopharm, 27(16), pp.125~128 (2018)
  32. Li YP, "Application of Bushen Huoluo Fang in children with repeated purulent tonsillitis", Chin Foreign Med Res, 16(23), pp.158~159 (2018)
  33. Shen C, "Observation on the therapeutic effect of Qingre Xiaoyong decoction on children with acute suppurative tonsillitis", Guangming J Chin Med, 32(8), pp.1125~1127 (2017)
  34. Chen Y, "Clinical observation of modified Chaige Jieji decoction treating acute pediatric tonsillitis", Tianjin J Tradit Chin Med, 34(9), pp.601~603 (2017)
  35. Zhu XY, "Observation and analysis of the clinical efficacy of Qingre Xiaoyan decoction in treating pediatric tonsillitis", World Latest Med Inf, 17(90), pp.95~98 (2017)
  36. Yang X, "Observation on efficacy of Shufengjiedu capsules in treatment of acute suppurative tonsillitis", Eval Anal Drug-Use Hosp China, 17(1), pp.57~59 (2017)
  37. Sun MM, "Effect of acetylspiramycin tablets combined with Liangge powder on acute suppurative tonsillitis in children", Chin J Rural Med Pharm, 24(13), pp.35~36 (2017)
  38. Pei J, "Clinical study and safety evaluation on Jeigeng Baihu granule in treatment of childhood acute suppurative tonsillitis (excessiveness of the stomach-fire)", Master, pp.2017
  39. Li S, "Therapeutic evaluation of Xuan’s Qingjie decoction on acute purulent tonsillitis in children", Chin J Mod Appl Pharm, 34(11), pp.1593~1596 (2017)
  40. Gao CM, "Clinical observation of Children Resuqing granules combined with antibiotic in the treatment of acute suppurative tonsillitis", World Chin Med, 12(4), pp.819~821 (2017)
  41. Ding YN, "The clinical effect of antelope horn decoction in the treatment of pyogenic tonsillitis in children", Guangming J Chin Med, 31(14), pp.2041~2042 (2016)
  42. Zhang W, "To observe curative effect of Liang-ge-suo-tao decoction in treatment of pediatric acute tonsillitis infection", Master, pp.2016
  43. Wu PH, "Since the proposed Qing pharynx and larynx soup in treatment of acute suppurative tonsillitis curative effect observation", J Clinical Med, 3(26), pp.5282~5283 (2016)
  44. Chen LY, "Clinical observation of pediatric acute suppurative tonsillitis treatment with Zhufeng Ganjie decoction", Pharmacol Clin Chin Mater Med, 32(1), pp.197~199 (2016)
  45. Fan WC, "40 cases of acute suppurative tonsillitis in children treated by Ru-e decoction", Fujian J Tradit Chin Med, 47(1), pp.60~61 (2016)
  46. Li XD, "Clinical observation of 58 cases of pediatric acute tonsillitis co-treated with Jibian Fang", J Pediatr Tradit Chin Med, 12(1), pp.49~51 (2016)
  47. Li ZY, "Clinical observation of pediatric acute suppurative tonsillitis treated with Yinqiao Baihu decoction combined with intravenous penicillin", Asia-Pacific Tradit Med, 12(23), pp.145~146 (2016)
  48. Hu YM, "Zhu futang practical pediatrics", pp.1177~1181 (2002), People's Medical Publishing House
  49. Children's Otolaryngology Committee of Pediatrician Branch of Chinese Medical Doctor Association, "Diagnosis and treatment of acute tonsillitis in children - clinical practice guidelines", Chin J Pract Pediatr, 32(3), pp.161~164 (2017)
  50. Tian YQ, "Otorhinolaryngology head and neck surgery", pp.137~ (2013), People's Medical Publishing House
  51. Chen HZ, "Practical internal medicine", pp.314~ (2009), People's Medical Publishing House
  52. Huang XZ, "Practical otorhinolaryngology head and neck surgery", pp.320~322 (2008), People's Medical Publishing House
  53. Tian YQ, "Otorhinolaryngology", pp.128~ (2000), People's Medical Publishing House
  54. Yan CX, "Pediatric otorhinolaryngology", pp.289~ (2000), Tianjin Science and Technology Press
  55. Xie MQ, "Infectious diseases of otolaryngology head and neck", pp.180~181 (2005), People's Medical Publishing House
  56. National Administration of Traditional Chinese Medicine, "Criteria for diagnosis and therapeutic effect of TCM disease", pp.126~ (1994), Nanjing University Press
  57. Wang SC, "Pediatrics of Chinese medicine", pp.83~87 (2006), Shanghai Science and Technology Press
  58. China Association of Chinese Medicine, "Guidelines for diagnosis and treatment of common diseases in the department of otolaryngology of traditional Chinese medicine", pp.318~ (2012), China Press of Traditional Chinese Medicine
  59. Wang SZ, "Otorhinolaryngology in Chinese medicine", pp.159~ (2007), China Press of Traditional Chinese Medicine
  60. Zheng XY, "Guiding principles for clinical study of new Chinese medicines", pp.79~80 (2002), China Medical Science and Technology Press
  61. Peng SQ, "Study on warm disease", pp.107~ (2001), Shanghai Science and Technology Press
  62. China Association of Chinese Medicine, "Guidelines for diagnosis and treatment of common diseases in pediatrics of traditional Chinese medicine", pp.6~7 (2012), China Press of Traditional Chinese Medicine
  63. Kim IR, "Bonchohak", pp.216~217 (2010), Young Lim Publishing Co
  64. Chen SW, "Tai ping hui min he ji ju fang", pp.141~ (1996), China Press of Traditional Chinese Medicine
  65. 고희정, "凉隔散의 RAW 264.7세포에서 항염증 효과", 박사, 제3의학과, pp.2012
  66. Chen SG, "Wai Ke Zheng Zong", pp.236~ (2011), China Medical Science Press
  67. Dong ZL, "Forsythiae Fructus: A review on its phytochemistry, quality control, pharmacology and pharmacokinetics", Molecules, 22(9), pp.1466~ (2017)
  68. 신상원, "甘草의 調和諸藥 효능에 대한 고찰", 대한한의학원전학회지, 33(1), pp.179~196 (2020), 대한한의학원전학회[DOI]
  69. 전경미, "단삼과 황금의 추출방법을 달리한 세포증식 효과 및 항산화 활성효과 연구", 아시안뷰티화장품학술지, 13(4), pp.495~502 (2015), 한국피부과학연구원
  70. Windfuhr JP, "Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management", Eur Arch Otorhinolaryngol, 273(4), pp.973~987 (2016)
  71. Korea Disease Control and Prevention Agency, "Guidelines for the antibiotic use in children with acute upper respiratory tract infections", 19~30 (2016)
  72. National Institute for Health and Clinical Excellence, "Prescribing of antibiotics for self limiting respiratory tract infections in adults and children in primary care 2008. (Clinical guideline 69)", NICE, ~ (2008)
  73. Centor R, "The diagnosis of strep throat in adults in the emergency room", Med Decis Making, 1, pp.239~246 (1981)
  74. McIsaac WJ, "A clinical score to reduce unnecessary antibiotic use in patients with sore throat", Can Med Assoc J, 158, pp.75~83 (1998)
  75. L. Brodsky, "Modern assessment of tonsils and adenoids", Pediatr Clin North Am, 36(6), pp.1551~1569 (1989)

관련 논문AI추천

이 간행물의 다른 논문 (7건)