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뇌팬톰을 이용한 삼차원 다중영상정합의 정확성 평가

Accuracy Evaluation of Three-Dimensional Multimodal Image Registration Using a Brain Phantom

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초록

다양한 의학 영상장비로부터 획득된 영상들간의 정합의 정확성은 방사선치료계획에서 매우 중요한 쟁점 중의 하나이다. 본 연구에서는 수제작된 뇌팬톰(brain phantom)을 이용한 영상정합의 정확성 평가방법을 연구하였다. 다중영상정합을 위해 CT-MR, CT-SPECT간의 Chamfer 정합(Chamfer matching)법을 적용하였다. 영상정합의 정확성은 팬톰 내에 삽입된 표적(target)들의 중심점의 비교를 통하여 평가되었다. CT-MR, CT-SPECT간의 삼차원 제곱근평균제곱(root-mean-square) 이동편차는 각각 2.1±0.8 mm와 2.8±1.4 mm이었다. 회전편차는 세 직교좌표축에서 2°이내였다. 이 오차들은 기존의 팬톰연구와 비교하여 합리적인 오차 허용범위 내에 들었다. 중첩한 CT-MR, CT-SPECT영상의 육안검증 또한 좋은 정합 결과를 보였다.

Abstract

Accuracy of registration between images acquired from various medical image modalities is one of the critical issues in radiation treatment plannig. In this study, a method of accuracy evaluation of image registration using a homemade brain phantom was investigated. Chamfer matching of CT-MR and CT-SPECT imaging was applied for the multimodal image registration. The accuracy of image correlation was evaluated by comparing the center points of the inserted targets of the phantom. The three dimensional root-mean-square translation deviations of the CT-MR and CT-SPECT registration were 2.1±0.8 mm and 2.8±1.4 mm, respectively. The rotational errors were < 2° for the three orthogonal axes. These errors were within a reasonable margin compared with the previous phantom studies. A visual inspection of the superimposed CT-MR and CT-SPECT images also showed good matching results.

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