알츠하이머 치매환자의 유명인이름대기 능력 손상 연구
Impaired Naming Ability of Famous People in Patients with Alzheimer’s Disease
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Background: Naming deficit is a common problem in patients with Alzheimer’s disease (AD). The purpose of this study is to investigate whether the ability of naming and recognition of famous people in patients with AD are different depending on the disease severity. Methods: Ten patients with MCI (CDR=0.5) and twenty patients with AD (ten for each group of CDR=1, and CDR=2) were included for this study. For normal controls (NC), ten healthy adults who were matched for age, gender, and education participated. Thirty picture stimuli were selected among people presenting three decades (1970-1990) in six specific areas such as president, actor, enterpriser, and so on. The confrontation naming test of objects (Korean-Boston Naming Test, K-BNT) and face recognition of famous people were also performed to find out the relations with the naming ability of famous people. Results: The abilities of famous people naming showed gradual decrease according to the severity of dementia, and there were significant differences among all the groups. The score of the recognition test of famous faces showed gradual decrease as the severity increased. Significant group differences were found in all comparisons except for the two group comparisons: between NC and CDR=0.5, and between CDR=0.5 and CDR=1. The ability of object naming (K-BNT) also decreased gradually as severity progressed. Significant group differences were found in all comparisons except between NC and CDR=0.5. Conclusions: The decreased naming ability of famous people may be the prodromal symptoms of AD. Clinical assessment of naming famous people can contribute to early detection of AD which may provide better sensitivity than object naming test. This finding also support that the neural substrates to process human face is different from those for object processing.
Abstract
Background: Naming deficit is a common problem in patients with Alzheimer’s disease (AD). The purpose of this study is to investigate whether the ability of naming and recognition of famous people in patients with AD are different depending on the disease severity. Methods: Ten patients with MCI (CDR=0.5) and twenty patients with AD (ten for each group of CDR=1, and CDR=2) were included for this study. For normal controls (NC), ten healthy adults who were matched for age, gender, and education participated. Thirty picture stimuli were selected among people presenting three decades (1970-1990) in six specific areas such as president, actor, enterpriser, and so on. The confrontation naming test of objects (Korean-Boston Naming Test, K-BNT) and face recognition of famous people were also performed to find out the relations with the naming ability of famous people. Results: The abilities of famous people naming showed gradual decrease according to the severity of dementia, and there were significant differences among all the groups. The score of the recognition test of famous faces showed gradual decrease as the severity increased. Significant group differences were found in all comparisons except for the two group comparisons: between NC and CDR=0.5, and between CDR=0.5 and CDR=1. The ability of object naming (K-BNT) also decreased gradually as severity progressed. Significant group differences were found in all comparisons except between NC and CDR=0.5. Conclusions: The decreased naming ability of famous people may be the prodromal symptoms of AD. Clinical assessment of naming famous people can contribute to early detection of AD which may provide better sensitivity than object naming test. This finding also support that the neural substrates to process human face is different from those for object processing.
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