레이저 조사 전후 자궁경부조직의 상대적 전기물성 스펙트럼 변화를 이용한 자궁경부 이형성증 치료검증도구의 가능성 평가
Feasibility Study of a Verification Tool for the Treatment of Cervical Intraepithelial Neoplasia Using Relative Electrical Property Change Before and After Laser Irradiation
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Since the detection of cervical intraepithelial neoplasia (CIN) is increasing due to regular cervical cancer screening, there is a high demand for simpler tools to diagnose and treat CIN in the clinic. In this study, we proposed an electric property of cervical tissue to verify treatment using a laser. At first, we observed the depth and width of ablated cervical tissues for 29 samples according to four different pulse energy of the fractional CO2 laser to find enough pulse energy to reach the basement layer for initiated CIN. And then, the relative frequency differences in impedance spectrum before and after laser irradiation for ten non-CIN samples were collected using bioimpedance spectroscopy with a multi-electrode probe. As a result, the laser ablated the cervical tissues with a depth of more than 300 μm at 100 mJ pulse energy. Also, we confirmed that the relative changes of electrical property for cervical tissue increased as the pulse energy of laser output increased, and the variation between samples decreased. Since the relative change in electrical properties of cervical tissue can be easily and quickly measured, the proposed tech- nique paves the way for further verification and follow-up study of laser treatment for CIN.
Abstract
Since the detection of cervical intraepithelial neoplasia (CIN) is increasing due to regular cervical cancer screening, there is a high demand for simpler tools to diagnose and treat CIN in the clinic. In this study, we proposed an electric property of cervical tissue to verify treatment using a laser. At first, we observed the depth and width of ablated cervical tissues for 29 samples according to four different pulse energy of the fractional CO2 laser to find enough pulse energy to reach the basement layer for initiated CIN. And then, the relative frequency differences in impedance spectrum before and after laser irradiation for ten non-CIN samples were collected using bioimpedance spectroscopy with a multi-electrode probe. As a result, the laser ablated the cervical tissues with a depth of more than 300 μm at 100 mJ pulse energy. Also, we confirmed that the relative changes of electrical property for cervical tissue increased as the pulse energy of laser output increased, and the variation between samples decreased. Since the relative change in electrical properties of cervical tissue can be easily and quickly measured, the proposed tech- nique paves the way for further verification and follow-up study of laser treatment for CIN.
참고문헌 (15)
- Cohen PA, "Cervical cancer", Lancet, 393, pp.169~182 (2019)
- 김영탁, "Current status of cervical cancer and HPV infection in Korea", Journal of Gynecologic Oncology, 20(1), pp.1~7 (2009), 대한부인종양학회
- Santesso N, "System-atic reviews and meta-analyses of benefits and harms of cryotherapy, LEEP, and cold knife conization to treat cervi-cal intraepithelial neoplasia", Int J Gynecol Obstet, 132(3), pp.266~271 (2016)
- Acharya G, "Pregnancy outcome after loop electrosur-gical excision procedure for the management of cervical intraepithelial neoplasia", Arch Gynecol Obstet, 272, pp.109~112 (2005)
- Rainer Kimmig, "Minimally invasive surgery for cervical cancer: consequences for treatment after LACC Study", Journal of Gynecologic Oncology, 29(4), pp.1~5 (2018), 대한부인종양학회[DOI]
- Khalafalla MM, "Mini-mal invasive laser treatment for female stress urinary incon-tinence", Int J Gynaecol Obstet, 2(2), pp.00035~ (2015)
- Inaba K, "High-risk human pap-illomavirus correlates with recurrence after laser ablation for treatment of patients with cervical intraepithelial neoplasia 3 : A long-term follow-up retrospective study", J Obstet Gynae-col Res, 2, pp.554~560 (2014)
- Fallani MG, "Laser CO2vaporization for high-grade cervical intraepithelial neoplasia : a long-term follow-up series", Gynecol Oncol, 91(1), pp.130~133 (2003)
- Gabriel S, "The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz", Phys Med Biol, 41(11), pp.2251~ (1996)
- Brown BH, "Detection of cervi-cal intraepithelial neoplasia using impedance spectroscopy : a prospective study", BJOG-Int J Obstet Gy, 112(6), pp.802~806 (2005)
- Zhang TT, "Tissue Characteriza-tion Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia", ELEC, 10(16), pp.1933~ (2021)
- Haemmerich D., "Biophysics of radiofrequency ablation", Crit Rev Biomed Eng, 38(1) (2010)
- Oh TI, "Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode probe to Screen for Cervical Intraepithelial Neoplasia", Diagnostics, 11(12), pp.2354~ (2021)
- Miklavčič D, "Wiley encyclopedia of biomedical engineering" (2006)
- Martinsen OG, Grimnes S., "Bioimpedance and bioelectricity basics" (2011), AP