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자궁경부 상피내종양의 환상투열요법 후 한약치료의 효과 : 체계적 문헌고찰 및 메타분석

Herbal Medicine for Cervical Intraepithelial Neoplasia After Loop Electrosurgical Excision Procedure: A Systematic Review and Meta-Analysis

이진무|장준복|이혜정|이창훈|황덕상|이수정|지해리
대한한방부인과학회 (The Society Of Oriental Obstetrics & Gynecology)|2020.05|대한한방부인과학회지 (The Journal of Oriental Obstetrics ＆ Gynecology)|제33권 제2호|pp. 44-62|DOI https://doi.org/10.15204/jkobgy.2020.33.2.044

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참고문헌

키워드

Herbal MedicineCervical DysplasiaCervical Intraepithelial NeoplasiaHuman Papilloma VirusLoop Electrosurgical Excision Procedure
주제분류한의학

초록

Objectives: The purpose of this study is to evaluate the effectiveness of herbal medicine for recovery and treatment of cervical intraepithelial neoplasia (CIN) after loop electrosurgical excision procedure (LEEP). Methods: We searched two english, one chinese and four korean database up to November 4, 2019. Randomised controlled trials (RCTs) were eligible. Primary outcome included Human papilloma virus (HPV) clearance rate and the effective ratio of treatment. And vaginal bleeding time and volume, improvement of symptoms, and recovery of wound were regarded as secondary outcomes. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool. Results: Of 47 screened, 10 RCTs were included. Number of participants per study ranged from 58 to 360. The studies which used HPV clearance rate as primary outcome were considered as low risk of bias. Most of the studies had considerable heterogeneity in terms of type of intervention, comparison and time-points for outcome measurement. Compared to LEEP alone, herbal vaginal suppository combined group showed favorable results for HPV clearance in patients (5 studies, n=627, 95% CI 1.26 to 1.55, I2=75%). And compared to LEEP alone, herbal external application also showed favorable results for HPV clearance in patients (2 studies, n=252, 95% CI 1.19 to 1.61, I2=86%). Three studies reported mild and temporary adverse events, and no serious adverse events were reported. Conclusions: The studies showed that herbal medicine can significantly effective on recovery of CIN after LEEP. However, included studies suffered from incomplete reporting, high or unclear risk of bias and substantial heterogeneity between studies. In the Future, further high-quality RCTs are needed to prove effectiveness of herbal medicine for CIN after LEEP and reduce the risk of bias.

Abstract

Objectives: The purpose of this study is to evaluate the effectiveness of herbal medicine for recovery and treatment of cervical intraepithelial neoplasia (CIN) after loop electrosurgical excision procedure (LEEP). Methods: We searched two english, one chinese and four korean database up to November 4, 2019. Randomised controlled trials (RCTs) were eligible. Primary outcome included Human papilloma virus (HPV) clearance rate and the effective ratio of treatment. And vaginal bleeding time and volume, improvement of symptoms, and recovery of wound were regarded as secondary outcomes. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool. Results: Of 47 screened, 10 RCTs were included. Number of participants per study ranged from 58 to 360. The studies which used HPV clearance rate as primary outcome were considered as low risk of bias. Most of the studies had considerable heterogeneity in terms of type of intervention, comparison and time-points for outcome measurement. Compared to LEEP alone, herbal vaginal suppository combined group showed favorable results for HPV clearance in patients (5 studies, n=627, 95% CI 1.26 to 1.55, I2=75%). And compared to LEEP alone, herbal external application also showed favorable results for HPV clearance in patients (2 studies, n=252, 95% CI 1.19 to 1.61, I2=86%). Three studies reported mild and temporary adverse events, and no serious adverse events were reported. Conclusions: The studies showed that herbal medicine can significantly effective on recovery of CIN after LEEP. However, included studies suffered from incomplete reporting, high or unclear risk of bias and substantial heterogeneity between studies. In the Future, further high-quality RCTs are needed to prove effectiveness of herbal medicine for CIN after LEEP and reduce the risk of bias.

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관련 논문AI추천

LEEP시술 절단면에 병변이 잔존하는 자궁경부상피내종양(CIN) 한의학적 치험 4례이은, 유병국, 이경엽한의병리학회 · 동의생리병리학회지2020 · 제34권 제3호인유두종 바이러스 감염과 자궁경부 이형성증과 관련된 한방 임상연구 동향 - 무작위 대조 비교 임상시험을 중심으로-이진무, 이창훈, 장준복, 정재령, 황덕상대한한방부인과학회 · 대한한방부인과학회지2019 · 제32권 제4호자궁경부 이형증과 관련한 한의약 연구 고찰- 자궁경부암 및 자궁경부 이형증 논문을 중심으로 -유정은, 윤영진, 이지연대한한방부인과학회 · 대한한방부인과학회지2013 · 제26권 제4호국내 학술지에 게재된 증례 연구 분석을 통한 자궁경부 상피내종양의 한의학적 치료에 대한 고찰백황옥, 이진무, 이창훈, 장준복, 황덕상대한한방부인과학회 · 대한한방부인과학회지2025 · 제38권 제4호한방치료로 호전된 고위험군 인유두종바이러스(HPV) 및 자궁경부 이형성증 5례 증례 보고강소정, 배광록, 이진무, 이창훈, 장준복, 황덕상대한한방부인과학회 · 대한한방부인과학회지2019 · 제32권 제1호미슬토 추출물 투여와 병행한 한방치료를 통해 호전된 재발성 자궁경부상피내종양 증례보고고은빈, 박남경, 이진무, 이창훈, 장준복, 최민영, 황덕상대한한방부인과학회 · 대한한방부인과학회지2022 · 제35권 제4호

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