A Case of Granulicatella adiacens Septicemia Identified by 16S rRNA Sequencing Analysis
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초록
Granulicatella adiacens는 배양조건이 까다로운 그람양성 구균으로 성장을 위해 L-cysteine, pyridoxal 또는 thiol 복합물을 필요로 하기 때문에 이전에 nutritionally variant streptococci로 분류되기도 하였다. 이 균은 구강, 장내 및 생식기 등에 상재균으로 존재하지만 드물게 심내막염, 안구내염 및 뇌수막염 등을 일으킨 예가 보고되었다. 저자들은 전통적인 균주 동정법 및 16S rRNA 염기서열 분석을 통하여 동정된 G. adiacens에 의한 패혈증 1예를 80세 담관암종 환자에서 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Granulicatella adiacens is one of the fastidious gram positive cocci previously described as nutritionally variant streptococci due to their requirement of L-cysteine, pyridoxal, or thiol compounds for growth. These bacteria have been identified as significant causative agents of endocarditis, opthalmic infections, and meningitis. We report a case of septicemia caused by G. adiacens in an 80-year-old patient with cholangiocarcinoma. The organism was identified by phenotypic and 16S rRNA sequencing analyses.
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