진행성 비소세포폐암 환자에서 발생한 Rhodotorula 패혈증 1예
Sepsis Due to Rhodotorula mucilaginosa in a Patient with Advanced Non-Small Cell Lung Cancer
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초록
Rhodotorula는 협막에 싸여진 원형 또는 난원형의 효모균으로 다발성(multilateral) 출아를 보이며, 요소분해 효소를 생성하고 탄수화물은 발효하지 않는다. Rhodotorula는 카로티노이드 색소를 생성하기 때문에 특징적인 연어살색 집락을 보인다. Rhodotorula는 자연환경에 분포하고 습윤한 피부에서 정상균무리로 존재하기 때문에 흔히 오염균으로 간주하였으나 최근에는 면역기능저하환자, 특히 중심정맥카테터를 삽입하고 있는 환자를 중심으로 병원균으로 인식되고 있는 추세이다. 그러나 아직 한국에서는 Rhodotorula 패혈증이 매우 드물게 보고되고 있는 바, 저자들은 항암치료 및 보존적 치료를 받아오던 비소세포폐암 환자에서 Rhodotorula mucilaginosa에 의한 패혈증이 발생하였기에 증례로 보고한다.
Abstract
Rhodotorula species are round to oval-shaped, multilateral budding, encapsulated yeasts that produce urease and do not ferment carbohydrates. Rhodotorula species form characteristic salmon-pink colored colonies owing to carotenoid pigment production. These yeasts form a part of the normal flora of moist skin and are found in the environment. Rhodotorula was traditionally considered a contaminant but is now progressively recognized as a human pathogen, especially in immunocompromised patients with central venous catheters. However, isolation of Rhodotorula species from blood has been very rarely reported in Korea. We report a case of sepsis due to Rhodotorula mucilaginosa infection in a patient who had received chemotherapy and supportive care for non-small cell lung cancer.
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