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A Case of Localized Fungal Pneumonia Caused by Rhodotorula mucilaginosa in an Immunocompetent Patient

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초록

Dear Editor, Rhodotorula species, belonging to the family Sporidiobolaceae, are yeasts that are present in the environment and can cause opportunistic infections in immunocompromised patients [1, 2]. Among Rhodotorula species, only R. mucilaginosa, R. glutinis, and R. minuta have been reported to cause human infections [1, 2]. Rhodotorula sp. are mostly isolated from the blood of immunocompromised patients, where they cause fungemia or catheter-related infections. Only one case of pneumonia caused by R. mucilaginosa has been reported to date in an immunocompromised patient [3]. We report the first case of fungal pneumonia caused by R. mucilaginosa in an immunocompetent patient. The infection was confirmed by fungal ribosomal RNA (rRNA) sequencing using wedge-resected lung tissue.

Abstract

Dear Editor, Rhodotorula species, belonging to the family Sporidiobolaceae, are yeasts that are present in the environment and can cause opportunistic infections in immunocompromised patients [1, 2]. Among Rhodotorula species, only R. mucilaginosa, R. glutinis, and R. minuta have been reported to cause human infections [1, 2]. Rhodotorula sp. are mostly isolated from the blood of immunocompromised patients, where they cause fungemia or catheter-related infections. Only one case of pneumonia caused by R. mucilaginosa has been reported to date in an immunocompromised patient [3]. We report the first case of fungal pneumonia caused by R. mucilaginosa in an immunocompetent patient. The infection was confirmed by fungal ribosomal RNA (rRNA) sequencing using wedge-resected lung tissue.

참고문헌 (8)

  1. Wirth F, "Epidemiology of Rhodotorula: an emerging pathogen", Interdiscip Perspect Infect Dis, 2012, pp.465717~ (2012)
  2. Tuon FF, "Rhodotorula infection. A systematic review of 128 cases from literature", Rev Iberoam Micol, 25, pp.135~140 (2008)
  3. Fischer J, "Rhodotorula mucilaginosa as a cause of recurrent pulmonary infection and liver infiltration in a patient with CLL", Ann Hematol, 95, pp.1569~1570 (2016)
  4. Guarner J, "Histopathologic diagnosis of fungal infections in the 21st century", Clin Microbiol Rev, 24, pp.247~280 (2011)
  5. CLSI, "Interpretive criteria for identification of bacteria and fungi by targeted DNA sequencing" (2018), Clinical and Laboratory Standards Institute
  6. 배태원, "진행성 비소세포폐암 환자에서 발생한 Rhodotorula 패혈증 1예", Laboratory Medicine Online, 6(2), pp.102~105 (2016), 대한진단검사의학회
  7. Hong HK, "A case of Rhodotorula mucilaginosa peritonitis undergoing continuous ambulatory peritoneal dialysis in a neonate with acute renal failure", Neonatal Med, 10, pp.94~98 (2003)
  8. 김현아, "Catheter-Associated Rhodotorula mucilaginosa Fungemia in an Immunocompetent Host", Infection and Chemotherapy, 45(3), pp.339~342 (2013), 대한감염학회

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