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RhD 음성/변이형 한국인 환자의 수혈전략

Transfusion Strategy of RhD-negative/variant Patients in the Korean Population

이선아|최영실|김준년|천세종|조덕|권정란|양형석
대한진단검사의학회 (Korean Society For Laboratory Medicine)|2017.07|Laboratory Medicine Online|제7권 제3호|pp. 89-93

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참고문헌

키워드

TransfusionGenotypingRHDDEL

초록

한국인은 D 음성자가 0.15%로 극히 드문데, 이중 약 15-17%가RHD 유전자 검사에 의해 DEL형으로 재 분류될 것이다. 향후 이들 DEL형 혈액제제는 D음성 환자에게 공급되지 않을 전망이므로 D음성 재고는 감소하고, DEL형 재고는 상대적으로 증가할 전망이다. 따라서, 이러한 한국에서의 상황을 고려한 새로운 수혈전략이 필요하게 되었다. 이에 본 종설에서는 가임기 여성 여부, 항-D 항체 보유 여부, 그리고 Asia type DEL형 유무를 고려한 보다 세분화된 수혈전략에 대해 논의하였다.

Abstract

The prevalence of RhD-negative individuals in the Korean population is approximately 0.15-0.30% and the supply of RhD-negative blood often faces potential shortage. Furthermore, 15-17% of serologically RhD-negative Korean individuals were revealed to be DEL variants and should be treated as RhD-positive when being considered as blood donors. This change is expected to result in a further shortage of RhD-negative blood supply, whereas surplus DEL variant blood stock is created. Therefore, it is now required to amend blood donation and supply policies, and transfusion strategies. In this review, a new transfusion strategy for patients with RhD-negative or variant blood in Korea is discussed, with particular interest in women of child-bearing age, patients with anti-D, and Asia type DEL (c.1227G>A) variants.

참고문헌 (30)

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관련 논문AI추천

Planned Transfusion of D-Positive Blood Components in an Asia Type DEL Patient: Proposed Modification of the Korean National Guidelines for Blood Transfusion조덕, 서지영, 양지혁, 천세종, 최수인대한진단검사의학회 · Annals of Laboratory Medicine2019 · 제39권 제1호일부 한국인의 Rh표현형 빈도권계철, 박숙자, 유재관, 주현정대한임상검사과학회 · 대한임상검사과학회지1998 · 제30권 제2호RhD 양성 농축적혈구 35단위 수혈 후 Anti-D가 검출되지 않은 RhD 음성 1예조덕, 김재룡, 김지혜, 류남희, 이원목, 전동석, 하정숙대한진단검사의학회 · Annals of Laboratory Medicine2007 · 제27권 제5호Primary anti-D Immunization by DEL Red Blood Cells김경은, 김경희, 김정만, 박경운, 우광숙, 한진영대한진단검사의학회 · Annals of Laboratory Medicine2009 · 제29권 제4호Application of Multiplex Ligation-Dependent Probe Amplification Assay for Genotyping Major Blood Group Systems Including DEL Variants in the D-Negative Korean Population김반석, 김신영, 김현옥, 이승태, 최종락대한진단검사의학회 · Annals of Laboratory Medicine2018 · 제38권 제1호RhD 음성 환자에서 확인된 RHD-CE(3-8)-D Hybrid형의 국내 최초 증례조덕, 김태열, 배고은, 서지영, 유홍비대한진단검사의학회 · Laboratory Medicine Online2022 · 제12권 제3호

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