Planned Transfusion of D-Positive Blood Components in an Asia Type DEL Patient: Proposed Modification of the Korean National Guidelines for Blood Transfusion
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DEL type red blood cells (RBCs) are characterized by the expression of extremely low levels of D-antigen, and thus, they cannot be detected by routine serologic D typing or a weak D test but are revealed by RHD genotyping or adsorption-elution studies [1]. The most common DEL phenotype is RHD (NM_016124.4: c.1227G>A), which is also referred to as Asia type DEL [2] and accounts for 94.7% of all Korean DEL cases [1]. Although DEL is a rare phenotype in individuals of European ethnicity [3], it is found in approximately 10–33% of serologically D-negative East Asian individuals of serologically D-negative East Asian individuals [1].
Abstract
DEL type red blood cells (RBCs) are characterized by the expression of extremely low levels of D-antigen, and thus, they cannot be detected by routine serologic D typing or a weak D test but are revealed by RHD genotyping or adsorption-elution studies [1]. The most common DEL phenotype is RHD (NM_016124.4: c.1227G>A), which is also referred to as Asia type DEL [2] and accounts for 94.7% of all Korean DEL cases [1]. Although DEL is a rare phenotype in individuals of European ethnicity [3], it is found in approximately 10–33% of serologically D-negative East Asian individuals of serologically D-negative East Asian individuals [1].
참고문헌 (9)
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