Periadnexal Mucin as an Additional Histopathologic Feature of Chronic Eczematous Dermatitis
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Background: Cutaneous mucinoses are a heterogeneousgroup of disorders characterized by an abnormal amount ofmucin in the skin. However, the pathomechanism of an excessivemucin deposition in the skin is still unknown. Eczematous dermatitis is sub-classified histologically intoacute, subacute, and chronic variants. The characteristic histopathologicfindings for chronic eczema are variable. However, periadnexal mucin deposition is not known as afeature of chronic eczema. Objective: To evaluate the presenceof periadnexal mucin deposition in chronic eczematousdermatitis. Methods: We analyzed the skin biopsy specimensfrom 36 patients who were pathologically diagnosedwith chronic eczematous dermatitis. Alcian blue, colloidaliron, and periodic acid-Schiff stains were used to evaluate themucin deposition in histologic sections. Two dermatologistsand two dermatopathologists evaluated the degree of mucindeposition using a 4-point scale. Results: Various amounts ofmucin deposition were observed in the periadnexal area ofpatients who were diagnosed with chronic eczema. Mucindeposition was more visible after staining with mucin-specificstains. Evaluation of the staining analysis scores revealedthat the staining intensities were significantly higher in patientswith chronic eczema than age- and site-matched controls(normal, acute to subacute eczema, and psoriasis vulgaris). Conclusion: Periadnexal mucin (secondary mucinoses)may be an additional finding of chronic eczematousdermatitis.
Abstract
Background: Cutaneous mucinoses are a heterogeneousgroup of disorders characterized by an abnormal amount ofmucin in the skin. However, the pathomechanism of an excessivemucin deposition in the skin is still unknown. Eczematous dermatitis is sub-classified histologically intoacute, subacute, and chronic variants. The characteristic histopathologicfindings for chronic eczema are variable. However, periadnexal mucin deposition is not known as afeature of chronic eczema. Objective: To evaluate the presenceof periadnexal mucin deposition in chronic eczematousdermatitis. Methods: We analyzed the skin biopsy specimensfrom 36 patients who were pathologically diagnosedwith chronic eczematous dermatitis. Alcian blue, colloidaliron, and periodic acid-Schiff stains were used to evaluate themucin deposition in histologic sections. Two dermatologistsand two dermatopathologists evaluated the degree of mucindeposition using a 4-point scale. Results: Various amounts ofmucin deposition were observed in the periadnexal area ofpatients who were diagnosed with chronic eczema. Mucindeposition was more visible after staining with mucin-specificstains. Evaluation of the staining analysis scores revealedthat the staining intensities were significantly higher in patientswith chronic eczema than age- and site-matched controls(normal, acute to subacute eczema, and psoriasis vulgaris). Conclusion: Periadnexal mucin (secondary mucinoses)may be an additional finding of chronic eczematousdermatitis.
참고문헌 (14)
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