Increased Expression of Interleukin-12 in Lesional Skin of Atopic Dermatitis Patients with Psoriasiform Features on Histopathology: An Immunohistochemical Study
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Based on clinical and genetic differences, atopic dermatitis (AD) and psoriasis have been classified in two different diseases, but recently, some authors regarded them as in one spectrum. The histological similarities including epidermal hyperplasia between chronic stages of AD and psoriasis supports the presence of two diseases in one spectrum. Objective: We investigated clinical and immunohistopathological characteristics of adult Korean patients with AD showing psoriasiform chronic dermatitis on histopathology. Methods: In total, 59 Korean patients with chronic AD were enrolled. Clinical, laboratory, and histopathological features were compared between AD patients with psoriasiform features and those with non-psoriasiform chronic dermatitis features on histology. In addition, immunohistopathological characteristics were analyzed using antibodies for key regulatory and effector cytokines in psoriasis. Results: Fifteen patients (25.4%) showed a more “psoriasiform” histological appearance. The lesions in patients with psoriasiform features often showed clearer boundaries and noticeable scaling. The interleukin (IL)-23 expression in the psoriasiform chronic dermatitis group was not different from that in the psoriasis group, but the IL-17 expression was less than that in the psoriasis group. In the case of IL-12, multiple dermal inflammatory cells with dendrites were stained in the psoriasiform chronic dermatitis group compared with the 2 other non-psoriasiform subgroups. Conclusion: The results suggest that IL-12 secreted from dermal inflammatory cells might be one of the important factors associated with the formation of psoriasiform features in chronic AD. However, further studies are required to better define the specific role of IL-12.
Abstract
Based on clinical and genetic differences, atopic dermatitis (AD) and psoriasis have been classified in two different diseases, but recently, some authors regarded them as in one spectrum. The histological similarities including epidermal hyperplasia between chronic stages of AD and psoriasis supports the presence of two diseases in one spectrum. Objective: We investigated clinical and immunohistopathological characteristics of adult Korean patients with AD showing psoriasiform chronic dermatitis on histopathology. Methods: In total, 59 Korean patients with chronic AD were enrolled. Clinical, laboratory, and histopathological features were compared between AD patients with psoriasiform features and those with non-psoriasiform chronic dermatitis features on histology. In addition, immunohistopathological characteristics were analyzed using antibodies for key regulatory and effector cytokines in psoriasis. Results: Fifteen patients (25.4%) showed a more “psoriasiform” histological appearance. The lesions in patients with psoriasiform features often showed clearer boundaries and noticeable scaling. The interleukin (IL)-23 expression in the psoriasiform chronic dermatitis group was not different from that in the psoriasis group, but the IL-17 expression was less than that in the psoriasis group. In the case of IL-12, multiple dermal inflammatory cells with dendrites were stained in the psoriasiform chronic dermatitis group compared with the 2 other non-psoriasiform subgroups. Conclusion: The results suggest that IL-12 secreted from dermal inflammatory cells might be one of the important factors associated with the formation of psoriasiform features in chronic AD. However, further studies are required to better define the specific role of IL-12.
참고문헌 (15)
- Guttman-Yassky E, "Contrasting pathogenesis of atopic dermatitis and psoriasis--part I : clinical and pathologic concepts", J Allergy Clin Immunol, 127, pp.1110~1118 (2011)
- Baurecht H, "Genomewide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms", Am J Hum Genet, 96, pp.104~120 (2015)
- Guttman-Yassky E, "Contrasting pathogenesis of atopic dermatitis and psoriasis--part II : immune cell subsets and therapeutic concepts", J Allergy Clin Immunol, 127, pp.1420~1432 (2011)
- Noda S, "The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization", J Allergy Clin Immunol, 136, pp.1254~1264 (2015)
- Leung DY, "Atopic dermatitis: age and race do matter!", J Allergy Clin Immunol, 136, pp.1265~1267 (2015)
- Eichenfield LF, "Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis", J Am Acad Dermatol, 70, pp.338~351 (2014)
- Elder DE, "Lever's histopathology of the skin" (2015), Wolters Kluwer
- Wilsmann-Theis D, "Facing psoriasis and atopic dermatitis: are there more similarities or more differences?", Eur J Dermatol, 18, pp.172~180 (2008)
- Homey B, "Cytokines and chemokines orchestrate atopic skin inflammation", J Allergy Clin Immunol, 118, pp.178~189 (2006)
- Lowes MA, "Pathogenesis and therapy of psoriasis", Nature, 445, pp.866~873 (2007)
- Nestle FO, "Psoriasis", N Engl J Med, 361, pp.496~509 (2009)
- Günther C, "CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells", J Immunol, 174, pp.1723~1728 (2005)
- Ferran M, "Circulating CLA+ T cell subsets inversely correlate with disease severity and extension in acute psoriasis but not in chronic plaque psoriasis", Eur J Dermatol, 18, pp.647~650 (2008)
- Saeki H, "Efficacy and safety of ustekinumab in Japanese patients with severe atopic dermatitis: a randomized, double-blind, placebo-controlled, phase II study", Br J Dermatol, 177, pp.419~427 (2017)
- Samuel RJ, "Ustekinumab for severe atopic dermatitis : an important negative study", Br J Dermatol, 177, pp.339~341 (2017)