항GQ1b항체와 항GT1a항체가 동시 검출된 환자에서 공통적으로 나타난 안구인두마비
Oculopharyngeal Palsy in Patients with Coexistence of Anti-GQ1b and GT1a Antibodies
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The presence of antiganglioside antibodies is closely associated with the clinical characteristics of Guillain-Barrésyndrome (GBS), as evidenced by the presence of anti-GQ1b antibody in Miller-Fisher syndrome and anti-GT1a antibodyin a pharyngeal-cervical-brachial variant of GBS. We report herein three patients harboring both anti-GT1a andanti-GQ1b antibodies who all exhibited oculopharyngeal palsy and additional features of ataxia, facial palsy, internalophthalmoplegia, and visual disturbance. The findings of this study suggest that oculopharyngeal palsy is a commonclinical manifestation determined by the coexistence of anti-GQ1b and GT1a antibodies.
Abstract
The presence of antiganglioside antibodies is closely associated with the clinical characteristics of Guillain-Barrésyndrome (GBS), as evidenced by the presence of anti-GQ1b antibody in Miller-Fisher syndrome and anti-GT1a antibodyin a pharyngeal-cervical-brachial variant of GBS. We report herein three patients harboring both anti-GT1a andanti-GQ1b antibodies who all exhibited oculopharyngeal palsy and additional features of ataxia, facial palsy, internalophthalmoplegia, and visual disturbance. The findings of this study suggest that oculopharyngeal palsy is a commonclinical manifestation determined by the coexistence of anti-GQ1b and GT1a antibodies.
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