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다발뇌신경마비와 동공마비가 동반된 항 GQ1b 증후군

Multiple Cranial Neuropathies and Pupillary Areflexia Associated with Anti-GQ1b Antibody

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초록

The causes of multiple cranial neuropathies are variable, including infection, inflammation or neoplastic lesion. They also can be a presenting features of the atypical variant of the Guillain-Barre syndrome (GBS). In spite of careful clinical investigation, etiology often remains unknown in many cases. We describe a patient who presented with ophthalmoplegia with pupillary areflexia, bulbar dysfunction, and bilateral facial palsy after upper respiratory tract infection and had significant elevation of anti-GQ1b antibody titer. We suggest that pupillary areflexia should be recognized as another feature that may be present in conditions of the anti-GQ1b antibody syndrome.

Abstract

The causes of multiple cranial neuropathies are variable, including infection, inflammation or neoplastic lesion. They also can be a presenting features of the atypical variant of the Guillain-Barre syndrome (GBS). In spite of careful clinical investigation, etiology often remains unknown in many cases. We describe a patient who presented with ophthalmoplegia with pupillary areflexia, bulbar dysfunction, and bilateral facial palsy after upper respiratory tract infection and had significant elevation of anti-GQ1b antibody titer. We suggest that pupillary areflexia should be recognized as another feature that may be present in conditions of the anti-GQ1b antibody syndrome.

참고문헌 (10)

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  5. Lyu RK, "Acute multiple cranial neuropathy: a variant of Gullian Barre syndrome", Muscle Nerve, 30, pp.433~436 (2004)
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  7. Odaka M, "Anti-GQ1b IgG antibody syndrome: clinical and immunological range", J Neurol Neurosurg Psychiatry, 70, pp.50~55 (2001)
  8. Yuki N, "Acute ophthalmoparesis (without ataxia) associated with anti-GQ1b IgG antibody", Ophthalmology, 108, pp.196~200 (2001)
  9. Yuki N, "Isolated internal ophthalmoplegia associated with IgG anti-GQ1b antibody", Neurology, 51, pp.515~516 (1998)
  10. Radziwill AJ, "Bogousslavsky J:Isolated internal ophthalmoplegia associated with IgG anti-GQ1b antibody", Neurology, 50, pp.307~ (1998)

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