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양측 외전신경마비만을 보인 비전형적 Miller-Fisher 증후군

Bilateral Sixth Nerve Palsies as the Sole Manifestation of Atypical Miller-Fisher Syndrome

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주제분류신경과학

초록

Recently, we encountered a man with isolated bilateral sixth nerve palsies and areflexia whose titer of anti-GQ1b IgG antibody was elevated. We propose that bilateral sixth nerve palsies can be the sole manifestation of “anti-GQ1b antibody syndromes” and that patients with isolated bilateral sixth nerve palsies should be administered an anti-GQ1b antibody test for the diagnosis of acute immune-related neuropathy.

Abstract

Recently, we encountered a man with isolated bilateral sixth nerve palsies and areflexia whose titer of anti-GQ1b IgG antibody was elevated. We propose that bilateral sixth nerve palsies can be the sole manifestation of “anti-GQ1b antibody syndromes” and that patients with isolated bilateral sixth nerve palsies should be administered an anti-GQ1b antibody test for the diagnosis of acute immune-related neuropathy.

참고문헌 (9)

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  3. Bayrak AO, "A case of bilateral simultaneous sixth cranial nerve palsies secondary to diabetes mellitus", J Neuroophthalmol, 26, pp.177~179 (2006)
  4. Lo YL, "Clinical and immunological spectrum of the Miller Fisher syndrome", Muscle Nerve, 36, pp.615~627 (2007)
  5. Chan YC, "Acute ophthalmoplegia with pupillary areflexia associated with anti-GQ1b antibody", J Clin Neurosci, 11, pp.658~660 (2004)
  6. 김종국, "내안근마비를 동반한 항GQ1b 항체증후군 3예", 대한신경과학회지, 25(1), pp.115~118 (2007), 대한신경과학회
  7. Odaka M, "Anti-GQ1b IgG antibody syndrome: clinical and immunological range", J Neurol Neurosurg Psychiatry, 70, pp.50~55 (2001)
  8. Tatsumoto M, "Isolated abducens nerve palsy as a regional variant of Guillain-Barre syndrome", J Neurol Sci, 243, pp.35~38 (2006)
  9. Yuki N, "Acute ophthalmoparesis (without ataxia) associated with anti-GQ1b IgG antibody: clinical features", Ophthalmology, 108, pp.196~200 (2001)

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