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논문KCI 등재

파킨슨병과 다계통위축증 감별 진단에 정량적 18-fluorodeoxyglucose PET의 유용성

The Quantitative 18-fluorodeoxyglucose PET Study in the Differential Diagnosis between Idiopathic Parkinson's Disease and Multiple System Atrophy

유영훈|이명식|이승엽|류철형
대한신경과학회 (Korean Neurological Association)|2006.02|대한신경과학회지 (Journal of the Korean Neurological Association)|제24권 제1호|pp. 31-37

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참고문헌

주제분류신경과학

초록

Abstract

Background: Overlapping clinical features of idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA) make it difficult to conduct an accurate differential diagnosis. We performed a quantitative F18- fluorodeoxyglucose PET (FDG PET) and measured the striatal and cerebellar glucose metabolism to evaluate the efficacy of a FDG PET study in the differential diagnosis between IPD and MSA. Methods: This study included 19 patients with IPD, 28 patients with MSA (MSA-P:MSA-C=19:9) and 12 age matched normal controls. A FDG PET study was performed in all subjects and the original PET image was corrected with the radioactivity curve obtained by repetitive sampling of the radial arterial blood. Results: The measurements of striatal and cerebellar glucose metabolisms of the patients with MSA-P were significantly lower than those of the patients with IPD (P<0.001). However, the measurement of the caudate nucleus provided the most reliable clue for the differential diagnosis between IPD and MSA-P (sensitivity 94.7% and specificity 94.7%). In the patients with MSA-C, the glucose metabolism of the cerebellar vermis (P<0.001), cerebellar cortex (P<0.001) and putamen (P<0.05) was significantly lower than those of the patients with IPD. Conclusions: Quantitative FDG PET is a useful and reliable method in making a differential diagnosis between IPD and MSA.

참고문헌 (31)

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