Metabolic Abnormalities in Idiopathic Parkinson's Diseases with Unilateral Symptoms
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Abstract
Authors investigated whether there is a lateral effect of 1H MRS observable metabolite ratios between the symptomatic and the nonsymptomatic side in the early stage of Parkinson’s disease with unilateral symptom. Localized in vivo 1H MR spectroscopy (MRS) was used to measure the metabolite levels in the symptomatic and the nonsymptomatic sides of the lentiform nucleus in Parkinson’s disease with unilateral symptom (N=25). The metabolite ratios of NAA/Cr and Cho/Cr in the symptomatic side were compared with those in the nonsymptomatic side. Significant metabolic lateral effect of NAA/(Cho+Cr) ratio was established between the symptomatic and the nonsymptomatic side of lentiform nucleus in Parkinson’s disease with unilateral symptom (p<0.05). The ratio of NAA/(Cho+Cr) homolateral to the sympatomatic side of the patient is also lower than that of the control (P<0.05). On the basis of NAA/Cr ratios of lentiform nucleus between the symptomatic and the nonsymptomatic side, the present 1H MRS study shows a significant neuronal laterality in Parkinson’s disease with unilateral symptom. In vivo 1H MRS may provide a diagnostic marker for neuronal dysfunction in Parkinson’s disease with unilateral symptom
참고문헌 (17)
- Daniel, S.E, "The neuropathology and neurochemistry of multiple system atrophy. In: Bannister R, Mathias C, eds. Autonomic failure. 3rd ed.", pp.564~585 (1992), Oxford: Oxford University Press
- Federico F, "Proton magnetic resonance spectroscopy in Parkinson’s disease and progressive supranuclear palsy", J Neurol Neurosurg Psychiatry, 62, pp.239~242 (1997)
- Gouider-Khouja N, "“pure” striatonigral degeneration and Parkinson’s disease: a comparative clinical study", Mov Disord, 10, pp.288~94 (1995)
- Brooks DJ, "Morphological and functional imaging studies on the diagnosis and progression of Parkinson's disease", J Neurol 247 Suppl 2, 247(2), pp.11~18 (2000)
- Hughes, A, "Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinicopathological study of 100 cases", J Neurol Neurosurg Psychiatry, 55, pp.181~184 (1992)
- Frahm J, "Localized high-resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo", Magn Reson Med, 9, pp.79~93 (1989)
- Iranzo A, "Proton magnetic resonance spectroscopy pattern of progressive multifocal leukoencephalopathy in AIDS", J-Neurol- Neurosurg-Psychiatry., 66, pp.520~523 (1999)
- Kreis R, "Localized 1H NMR spectroscopy in patients with chronic hepatic encephalopathy: analysis of change in cerebral glutamine, choline, and inositols.", NMR in Biomed, 4, pp.109~116 (1991)
- Petroff OAC, "High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy", Neurology, 39, pp.1197~1202 (1989)
- Ross B, "Clinical tools for the 90s: magnetic resonance spectroscopy and metabolic imaging", Eur J Radiology, 14, pp.128~140 (1992)
- Stern MB, "Magnetic resonance imaging in Parkinson’s disease and Parkinsonian syndromes", Neurology, 39, pp.1524~1526 (1989)
- Federico F, "Proton magnetic resonance spectroscopy in Parkinson’s disease and progressive supranuclear palsy", J Neurol Neurosurg Psychiatry, 62, pp.239~242 (1997)
- Bowen BC, "Proton MR spectroscopy of the brain in 14 patients with Parkinson disease", AJNR, 16, pp.61~68 (1995)
- Holshouser BA, "Localized proton NMR spectroscopy in the striatum of patients with idiopathic Parkinson’s disease: A multicenter pilot study", Magn Reson Med, 33, pp.589~594 (1995)
- Frost JJ, "Positron emission tomographic imaging of the dopamine transporter with 11C-win 35 428 reveals marked declines mild Parkinson’s disease", Ann Neurol, 34, pp.423~431 (1993)
- Otsuka M, "Differences in the reduced 18F-dopa uptakes of the caudate and putamen in Parkinson’s disease: correlations with the three main symptoms", J Neurol Sci, 136, pp.169~173 (1996)
- Ellis CM, "Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson's disease: a proton magnetic resonance spectroscopy study", Neurology, 49, pp.438~444 (1997)