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울금 검 제제가 알코올의 혈중농도와 숙취에 미치는 영향

Effects of Curcuma long gum preparation on the Blood Alcohol Level and Hangover

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초록

We conducted a single blind, randomized and crossover clinical trial in order to test the effect of curcuma longa herbal mixture on blood alcohol level and alcohol hangover in 19 healthy volunteers. The herbal mixture did not show a statistical significance in Cmax, Tmax and AUC in alcohol disposition. The herbal mixture did not also ameliorate blood laboratory result after alcohol consumption. In contrast, the herbal mixture is shown effective on alcohol hangover. In behavior tests, the fewer subjects in the herbal mixture group were impaired with alcohol than in reference group. Moreover, the symptom severity score in the herbal mixture was lower than that in reference group. The symptom severity score was statistically especially in stomach pain, diarrhea, concentration disorder, memory and bad breath at drinking day and one day after drinking. These results indicate that the general symptoms seemed to be recovered as time goes on. From these results, it was suggested that the herbal mixture have a beneficial effect on modulating alcohol hangover.

Abstract

We conducted a single blind, randomized and crossover clinical trial in order to test the effect of curcuma longa herbal mixture on blood alcohol level and alcohol hangover in 19 healthy volunteers. The herbal mixture did not show a statistical significance in Cmax, Tmax and AUC in alcohol disposition. The herbal mixture did not also ameliorate blood laboratory result after alcohol consumption. In contrast, the herbal mixture is shown effective on alcohol hangover. In behavior tests, the fewer subjects in the herbal mixture group were impaired with alcohol than in reference group. Moreover, the symptom severity score in the herbal mixture was lower than that in reference group. The symptom severity score was statistically especially in stomach pain, diarrhea, concentration disorder, memory and bad breath at drinking day and one day after drinking. These results indicate that the general symptoms seemed to be recovered as time goes on. From these results, it was suggested that the herbal mixture have a beneficial effect on modulating alcohol hangover.

참고문헌 (7)

  1. Verster JC, "The alcohol hangover-a puzzling phenomenon", Alcohol Alcohol, 43(2), pp.124~126 (2008)
  2. Wiese JG, "The alcohol hangover", Ann Intern Med, 132(11), pp.897~902 (2000)
  3. Harburg E, "Psychosocial factors, alcohol use, and hangover signs among social drinkers: a reappraisal", J Clin Epidemiol, 46(5), pp.413~422 (1993)
  4. Meilman PW, "Alcohol consumption by college undergraduates: current use and 10-year trends", J Stud Alcohol, 51(5), pp.389~395 (1990)
  5. Stockwell T, "Towards guidelines for low-risk drinking: quantifying the short- and long-term costs of hazardous alcohol consumption", Alcohol Clin Exp Res, 22(2Suppl), pp.63S~9S (1998)
  6. Kaivola S, "Hangover headache and prostaglandins: prophylactic treatment with tolfenamic acid", Cephalalgia, 3(1), pp.31~6 (1983)
  7. Khan MA, "Alcohol-induced hangover. A double-blind comparison of pyritinol and placebo in preventing hangover symptoms", Q J Stud Alcohol, 34(4), pp.1195~1201 (1973)

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