본문 바로가기
KERD
논문KCI 등재

SM-2015의 혈중 알코올 분해 및 숙취 개선 효과

Effects of SM-2015 on Blood Alcohol Clearance and Hangover

2

조회

0

다운로드

4

인용

0

참고문헌

키워드

주제분류한의학

초록

Objectives: This study investigated the effect of SM-2015 on blood alcohol clearance and hangover. We undertook this study to test whether SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Methods: Twenty healthy volunteers participated in this randomized crossover study. All participants were classified between an SM-2015 intake group (test group) and a non-intake group (control group). The primary outcome measure was the difference in blood alcohol concentration and hangover severity scores between the test and control groups. The secondary outcome measure was the difference in a liver function test (LFT) between the test and control groups. Results: After alcohol exposure, the sensitivity scores of blood alcohol concentration and hangover symptoms (sleepiness, dizziness, nausea, weakness, stomach pain, diarrhea, and concentration disorder) were significantly decreased in the SM-2015 intake group compared with the non-intake group. There were no differences in the LFT results between the SM-2015 intake group and the non-intake group. Conclusions: SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.

Abstract

Objectives: This study investigated the effect of SM-2015 on blood alcohol clearance and hangover. We undertook this study to test whether SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Methods: Twenty healthy volunteers participated in this randomized crossover study. All participants were classified between an SM-2015 intake group (test group) and a non-intake group (control group). The primary outcome measure was the difference in blood alcohol concentration and hangover severity scores between the test and control groups. The secondary outcome measure was the difference in a liver function test (LFT) between the test and control groups. Results: After alcohol exposure, the sensitivity scores of blood alcohol concentration and hangover symptoms (sleepiness, dizziness, nausea, weakness, stomach pain, diarrhea, and concentration disorder) were significantly decreased in the SM-2015 intake group compared with the non-intake group. There were no differences in the LFT results between the SM-2015 intake group and the non-intake group. Conclusions: SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.

참고문헌 (45)

  1. Swift R, "Alcohol hangover. Mechanisms and mediators", Alcohol Health Res World, 22, pp.54~60 (1998)
  2. Wiese JG, "The alcohol hangover", Ann Intern Med, 132(11), pp.897~902 (2000)
  3. 김성현, "땅콩새싹 추출물을 이용한 숙취해소 음료가 항산화 및 알코올분해 효소활성에 미치는 영향", 농업생명과학연구, 50(1), pp.223~231 (2016), 농업생명과학연구원[DOI]
  4. 이미애, "녹차카테킨(GTC)의 숙취해소 및 알코올 간독성 보호 효과", 대한임상검사과학회지, 46(4), pp.131~135 (2014), 대한임상검사과학회
  5. 박은미, "헛개나무 열매 추출물을 함유한 건강음료의 숙취 제거 효과", 한국식생활문화학회지, 21(1), pp.71~75 (2006), 한국식생활문화학회
  6. 이명렬, "참나물이 만성적으로 알코올 유도된 흰쥐의 간손상에 미치는 영향", 생명과학회지, 17(10), pp.1406~1413 (2007), 한국생명과학회
  7. Cho SH, "Effect of plant extracts on the activity of alcohol dehydrogenase and the antioxidation in alcohol-treated rat hepatocyte", J Korean Soc Food Sci Nutr, 30, pp.679~683 (2001)
  8. The co-textbook publishing committee of Korean oriental medicine school, "The herbal medicine", pp.451~452 (2004), Younglimsa
  9. 김정상, "갈근(Radix puerariae)과 죽력(Bambusae caules in Liquamen Phyllostachyos)을 함유한 숙취해소 음료가 알코올을 투여한 생쥐에 미치는 영향", 한국식품영양과학회지, 33(2), pp.318~323 (2004), 한국식품영양과학회
  10. 노경희, "건강한 남자 대학생에서 민들레즙 보충이 알코올에 의한 산화적 스트레스 및 숙취에 미치는 효과", 한국식품영양과학회지, 38(6), pp.683~693 (2009), 한국식품영양과학회
  11. Verster JC, "The alcohol hangover-a puzzling phenomenon", Alcohol & Alcoholism, 43(2), pp.124~126 (2008)
  12. Wiese JG, "The alcohol hangover", Ann Intern Med, 132(11), pp.897~902 (2000)
  13. "Scale of anti-hangover drink market"[URL]
  14. Yamahara J, "Biologicallyvactive principles of crude drugs. Ⅱ. Anti-allergic principles in “Shoseiryu-To” anti-inflammatory properties of paeoniflorin and its derivatives", J Pharmacobiodyn, 5, pp.921~929 (1982)
  15. Tan RX, "Biologically active substances from the genus Artemisia", Planta Med, 64, pp.295~302 (1998)
  16. Seol HC, "Extraction and identification of antioxidant components from Artemisia capillaris herba", Plant Food Hum Nutr, 58, pp.1~12 (2003)
  17. Kiso Y, "Antihepatotoxic principles of Artemisia capillaris buds", Planta Med, 50, pp.81~85 (1984)
  18. Mori H, "Immunological mechanisms of antitumor activity of some kinds of Chinese herbs:Meth A-induced delayed type hypersensitivity", Jpn J Pharmacol, 48, pp.37~46 (1988)
  19. Yamahara J, "The effect of scoparone, a coumarin derivative isolated from the Chinese crude drug Artemisiae capillaris flos, on the heart", Chem Pharm Bull, 37, pp.1297~1299 (1989)
  20. Kimura Y, "Effects of geniposide isolated from Gardenia jasminoides on metabolic alterations in high sugar diet-fed rats", Chem Pharm Bull, 30, pp.4444~4447 (1982)
  21. Peng CH, "The anti-tumor effect and mechanisms of action of penta-acetyl geniposide", Curr Cancer Drug Targets, 5, pp.299~305 (2005)
  22. 성기천, "천연 오미자 추출물의 약리, 화학적 특성 및 분석", 오일 및 응용과학 학회지, 28(3), pp.290~298 (2011), 한국유화학회
  23. Xing J, "A herbal composition of Semen Hoveniae, Radix Puerariae, and Fructus Schisandrae shows potent protective effects on acute alcoholic intoxication in rodent models", Evid Based Complement Alternat Med (2012)[DOI]
  24. Cheng N, "Antioxident and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4induced acute liver damage in mice", Food Chem Toxicol, 5, pp.234~240 (2013)
  25. Hikino H, "Antihepatotoxic actions of lignoids from Schizandra chinensis fruits", Planta Med, 50, pp.213~218 (1984)
  26. 한찬규, "오미자농축액이 급성주정중독량 및 장기간 주정을 투여한 흰쥐의 혈중 알코올 분해율과 간 기능 보호에 미치는 영향", 한국식품영양과학회지, 43(8), pp.1139~1147 (2014), 한국식품영양과학회
  27. Nakagiri R, "Small scale rat hepatocyte primary culture with applications for screening hepatoprotective substances", Biosci Biotechnol Biochem, 67, pp.1629~1635 (2003)
  28. Toda S, "Natural antioxidants (Ⅳ). Antioxidative components isolated from Schisandra fruit", Shoyakugaku Zasshi, 42, pp.156~159 (1988)
  29. Huang YS, "Antioxidative effects of three components isolated from fruit of schisandrae", Chinese J Pharmacol Toxicol, 4, pp.275~277 (1990)
  30. Jung BS, "Encyclopedia of medicine from the Countryside", pp.257~258 (2003), Younglimsa
  31. Lim DK, "Antioxidative Activity of Ethanol Extract from Korean Medicinal Plants", Korean J Food Sci Technol, 28(1), pp.83~89 (1996)
  32. Kim MS, "Antimicrobial Effects of Ethanol Extracts from Korean and Indonesian Plants", Korean J Food Sci Technol, 32(4), pp.949~958 (2000)
  33. 윤주호, "강황이 수종의 암세포에 미치는 영향", 대한한방내과학회지, 27(2), pp.429~443 (2006), 대한한방내과학회
  34. 정태산, "강황추출물이 Diethylnitrosamine과 CCl4로 유발된 흰쥐의 간암과 간 손상에 미치는 영향", 대한한의학 방제학회지, 22(1), pp.177~192 (2014), 대한한의학방제학회
  35. Jung SY, "Establishment of Functionality Evaluation System for Hangover Settlement of Health Functional Food", pp.14~ (2004), Ministry of Food and Drug Safety
  36. Harburg E, "Psychosocial factors, alcohol use, and hangover signs among social drinkers: a reappraisal", J Clin Epidemiol, 46(5), pp.413~422 (1993)
  37. Meilman PW, "Alcohol consumption by college undergraduates:current use and 10-year trends", J Stud Alcohol, 51(5), pp.389~395 (1990)
  38. Stockwell T, "Towards guidelines for low-risk drinking:quantifying the short- and long-term costs of hazardous alcohol consumption", Alcohol Clin Exp Res, 22(2 Suppl), pp.63S~69S (1998)
  39. Kaivola S, "Hangover headache and prostaglandins:prophylactic treatment with tolfenamic acid", Cephalalgia, 3(1), pp.31~36 (1983)
  40. Khan MA, "Alcohol-induced hangover. A double-blind comparison of pyritinol and placebo in preventing hangover symptoms", Q J Stud Alcohol, 34(4), pp.1195~1201 (1973)
  41. Park SY, "Improve effects of Artemisia Capillaris water extract on patient with fatty Liver disease", Korean living science association, (2), pp.169~170 (2007)
  42. Rohsenow DJ, "The Acute Hangover Scale: A new measure of immediate hangover symptoms", Addict Behav, 32(6), pp.1314~1320 (2007)
  43. Verster JC, "Alcohol hangover effects on memory functioning and vigilance performance after an evening of binge drinking", Neuropsychopharmacology, 28(4), pp.740~746 (2003)
  44. Rohsenow DJ, "Effects of heavy drinking by maritime academy cadets on hangover, perceived sleep, and next-day ship power plant operation", J Stud Alcohol, 67(3), pp.406~415 (2006)
  45. 정현숙, "神仙不醉丹 加減方의 숙취 예방효과에 대한 이중맹검 무작위배정 교차임상 예비연구", 대한한방내과학회지, 33(4), pp.511~519 (2012), 대한한방내과학회

관련 논문AI추천

神仙不醉丹 加減方의 숙취 예방효과에 대한 이중맹검 무작위배정 교차임상 예비연구강세영, 장인수, 정현숙, 한현진대한한방내과학회 · 대한한방내과학회지2012 · 제33권 제4호울금 검 제제가 알코올의 혈중농도와 숙취에 미치는 영향곡려영, 구교환, 김민수, 김진만, 남윤성, 방준석, 손의동, 임성혁, 정주철, 정지훈, 조성인한국임상약학회 · 한국임상약학회지2010 · 제20권 제1호랫드에서 Aldehyde Dehydrogenase Related Compounds의 알콜 및 알데히드 분해 효능평가강소라, 권흥택, 김배환, 신혜정, 정세영한국환경보건학회 · 한국환경보건학회지2023 · 제49권 제2호약용식물 추출물이 함유된 숙취해소음료의 생리활성 및 체내 알코올 분해 효능양재경, 이원희, 정지영, 하시영농업생명과학연구원 · 농업생명과학연구2017 · 제51권 제3호Effects of Paraprobiotic Limosilactobacillus fermentum HDB1098 on Hangover Improvement in Humans: A Randomized Double-Blind Placebo-Controlled Crossover Clinical TrialKang Dae-Jung, Kim Hyeon Jeong, Kim Yoo Kyung, Lee Seunghun, Yun Min-Kyu한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2025 · 제35권 방사선 유도 돌연변이체, 블랙베리 발효음료의알코올 대사 및 숙취 억제 효과소양강, 우현심, 이창욱, 정일윤, 조병옥, 조정근, 진창현(사)한국방사선산업학회 · 방사선산업학회지2013 · 제7권 제1호

이 간행물의 다른 논문 (7건)