한국 성인 남성의 알코올 분해의 약동학적 특징 및 영향요인
Elimination Rate and Pharmacokinetics of Alcohol in Korean Healthy Male Adults
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Objectives The objective of this study is to identify alcohol pharmacokinetics and to investi¬gate the correlations between various factors for alcohol metabolism of healthy Korean males. Methods The 101 recruited volunteers were randomized into two groups as one group pro¬vided 0.35 mg/mL/kg and 0.7 mg/mL/kg, the other. Blood alcohol concentration was measured and analyzed in enzymatic methods eight times from drinking point. Results Alcohol elimination rate (β) was found to be -0.0083%/h for low dose group and -0.0157%/h for the high dose group. The results indicate discrepancy in the legal criteria of alco¬hol elimination rate (-0.008%/h). The measured alcohol pharmacokinetic properties were follow¬ing : mean time to reach maximum alcohol concentration in blood was 30 minutes, absorption rate was 0.0197%, maximum alcohol concentration in blood was 0.4930%, and Area under the curve was 59.25. Also, alcohol elimination was not affected by age, smoking, total body water, drinking capacity, body mass index, blood cholesterol, body fat, and body fat ratio. Conclusion These results suggest that legal limitation could be adjusted in Korean males. Also the research should be extended including female and senior citizens for statistical significance of the research. These findings have contributed to our knowledge of the alcohol pharmacoki¬netics in Korean male.
Abstract
Objectives The objective of this study is to identify alcohol pharmacokinetics and to investi¬gate the correlations between various factors for alcohol metabolism of healthy Korean males. Methods The 101 recruited volunteers were randomized into two groups as one group pro¬vided 0.35 mg/mL/kg and 0.7 mg/mL/kg, the other. Blood alcohol concentration was measured and analyzed in enzymatic methods eight times from drinking point. Results Alcohol elimination rate (β) was found to be -0.0083%/h for low dose group and -0.0157%/h for the high dose group. The results indicate discrepancy in the legal criteria of alco¬hol elimination rate (-0.008%/h). The measured alcohol pharmacokinetic properties were follow¬ing : mean time to reach maximum alcohol concentration in blood was 30 minutes, absorption rate was 0.0197%, maximum alcohol concentration in blood was 0.4930%, and Area under the curve was 59.25. Also, alcohol elimination was not affected by age, smoking, total body water, drinking capacity, body mass index, blood cholesterol, body fat, and body fat ratio. Conclusion These results suggest that legal limitation could be adjusted in Korean males. Also the research should be extended including female and senior citizens for statistical significance of the research. These findings have contributed to our knowledge of the alcohol pharmacoki¬netics in Korean male.
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