Comparison of Th1 and Th17 Inflammatory Cytokine Profiles Between Chronic Plaque and Acute Guttate Psoriasis
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Background: The phenotypic heterogeneity of psoriasis is suspected to reflect differences in its pathogenesis, but not yet completely elucidated. Studies of the Th1 and Th17 cytokines associated with different phenotypes of psoriasis have yielded inconsistent results. Objective: To investigate the tissue expression levels of Th1 and Th17 cytokines among pa- tients with chronic plaque psoriasis, acute guttate psoriasis, and healthy control. Methods: A total of 20 patients with psoriasis (10 with chronic plaque type and 10 with acute guttate type) and 5 healthy controls were enrolled. The tissue mRNA and protein levels of following cytokines were measured: interleukin (IL)-12, IL-2, interferon (IFN)-γ, IL-23, IL-17A, and IL-22. Results: The tissue mRNA levels of IL-12, IFN-γ, IL-23, IL-17A, IL-22 and the protein lev- els of IL-12, IL-2, IFN-γ, IL-17A, IL-22 were significantly increased in the psoriasis patients compared with the healthy controls. In comparisons of the subtypes, the tissue mRNA level of IFN-γ was increased in acute guttate psoriasis, whereas the protein levels of IL-12 and IL-17A were significantly increased in chronic plaque psoriasis. The cytokine ratios of IL-17A/IL-2 and IL-22/IL-2 were significantly higher in chronic plaque psoriasis than in acute guttate psoriasis. Conclusion: We confirmed that the tissue levels of Th1 and Th17 cytokines were increased in psoriasis patients compared with healthy controls. The increased IFN-γ mRNA level in acute guttate psoriasis and increased IL-12 and IL-17A protein levels in chronic plaque psoriasis suggest that an imbalance between Th1 and Th17 cytokines may play a role in the phenotypic transition of psoriasis.
Abstract
Background: The phenotypic heterogeneity of psoriasis is suspected to reflect differences in its pathogenesis, but not yet completely elucidated. Studies of the Th1 and Th17 cytokines associated with different phenotypes of psoriasis have yielded inconsistent results. Objective: To investigate the tissue expression levels of Th1 and Th17 cytokines among pa- tients with chronic plaque psoriasis, acute guttate psoriasis, and healthy control. Methods: A total of 20 patients with psoriasis (10 with chronic plaque type and 10 with acute guttate type) and 5 healthy controls were enrolled. The tissue mRNA and protein levels of following cytokines were measured: interleukin (IL)-12, IL-2, interferon (IFN)-γ, IL-23, IL-17A, and IL-22. Results: The tissue mRNA levels of IL-12, IFN-γ, IL-23, IL-17A, IL-22 and the protein lev- els of IL-12, IL-2, IFN-γ, IL-17A, IL-22 were significantly increased in the psoriasis patients compared with the healthy controls. In comparisons of the subtypes, the tissue mRNA level of IFN-γ was increased in acute guttate psoriasis, whereas the protein levels of IL-12 and IL-17A were significantly increased in chronic plaque psoriasis. The cytokine ratios of IL-17A/IL-2 and IL-22/IL-2 were significantly higher in chronic plaque psoriasis than in acute guttate psoriasis. Conclusion: We confirmed that the tissue levels of Th1 and Th17 cytokines were increased in psoriasis patients compared with healthy controls. The increased IFN-γ mRNA level in acute guttate psoriasis and increased IL-12 and IL-17A protein levels in chronic plaque psoriasis suggest that an imbalance between Th1 and Th17 cytokines may play a role in the phenotypic transition of psoriasis.
참고문헌 (18)
- Choe YB, "A comparison of serum inflammatory cytokines according to phenotype in patients with psoriasis", Br J Dermatol, 167, pp.1400~ (2012)
- Christophers E, "Explaining phenotype heterogeneity in patients with psoriasis", Br J Dermatol, 158, pp.437~441 (2008)
- Martin BA, "How great is the risk of further psoriasis following a single episode of acute guttate psoriasis?", Arch Dermatol, 132, pp.717~718 (1996)
- Lowes MA, "Pathogenesis and therapy of psoriasis", Nature, 445, pp.866~873 (2007)
- Christophers E, "Bimodal immune activation in psoriasis", Br J Dermatol, 170, pp.59~65 (2014)
- 노남경, "Tissue and Serum Inflammatory Cytokine Levels in Korean Psoriasis Patients: A Comparison between Plaque and Guttate Psoriasis", Annals of Dermatology, 27(6), pp.738~743 (2015), 대한피부과학회
- 전지훈, "Gene Expression Analysis of Inflammatory Cytokines in Korean Psoriatic Patients", Annals of Dermatology, 29(4), pp.422~426 (2017), 대한피부과학회
- Hwang YJ, "Serum levels of LL-37 and inflammatory cytokines in plaque and guttate psoriasis", Mediators Inflamm, 2014, pp.268257~ (2014)
- 김병수, "Is It Possible to Discontinue Tumor Necrosis Factor Antagonists after Psoriasis Remission?", Annals of Dermatology, 31(5), pp.495~501 (2019), 대한피부과학회[DOI]
- Ko HC, "Clinical course of guttate psoriasis : long-term follow-up study", J Dermatol, 37, pp.894~899 (2010)
- Liu XY, "Comparison between guttate and plaque psoriasis in terms of serum inflammatory cytokines and antimicrobial peptides", Chin Med J(Engl), 133, pp.3004~3006 (2020)
- Perl K, "Reduced changes in protein compared to mRNA levels across non-proliferating tissues", BMC Genomics, 18, pp.305~ (2017)
- 김태균, "The pathophysiological role of dendritic cell subsets in psoriasis", BMB Reports, 47(2), pp.60~68 (2014), 생화학분자생물학회
- Benezeder T, "Resolution of plaque-type psoriasis : what is left behind(and reinitiates the disease)", Semin Immunopathol, 41, pp.633~644 (2019)
- Kurtovic NO, "Serum concentrations of interferon gamma(IFN-γ)in patients with psoriasis : correlation with clinical type and severity of the disease", Med Arch, 72, pp.410~413 (2018)
- Yan K, "The distinct role and regulatory mechanism of IL-17 and IFN-γ in the initiation and development of plaque vs guttate psoriasis", J Dermatol Sci, 92, pp.106~113 (2018)
- Baliwag J, "Cytokines in psoriasis", Cytokine, 73, pp.342~350 (2015)
- Kulig P, "IL-12 protects from psoriasiform skin inflammation", Nat Commun, 7, pp.13466~ (2016)