The pathophysiological role of dendritic cell subsets in psoriasis
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Psoriasis is a chronic inflammatory disorder characterized byan erythematous scaly plaque of the skin and is occasionallyaccompanied by systemic complications. In the psoriaticlesions, an increased number of cytokine-producing dendriticcells and activated T cells are observed, which indicate thatpsoriasis is a prototype of an immune-mediated dermatosis. During the last decade, emerging studies demonstrate novelroles for the dendritic cell subsets in the process of diseaseinitiation and maintenance of psoriasis. In addition, recentlydiscovered anti-psoriatic therapies, which specifically targetinflammatory cytokines produced by lesional dendritic cells,bring much better clinical improvement compared toconventional treatments. These new therapies implicate thecrucial importance of dendritic cells in psoriasis pathogenesis. This review will summarize and discuss the dendritic cellsubsets of the human skin and their pathophysiologicalinvolvement in psoriasis based on mouse- and patient-oriented studies.
Abstract
Psoriasis is a chronic inflammatory disorder characterized byan erythematous scaly plaque of the skin and is occasionallyaccompanied by systemic complications. In the psoriaticlesions, an increased number of cytokine-producing dendriticcells and activated T cells are observed, which indicate thatpsoriasis is a prototype of an immune-mediated dermatosis. During the last decade, emerging studies demonstrate novelroles for the dendritic cell subsets in the process of diseaseinitiation and maintenance of psoriasis. In addition, recentlydiscovered anti-psoriatic therapies, which specifically targetinflammatory cytokines produced by lesional dendritic cells,bring much better clinical improvement compared toconventional treatments. These new therapies implicate thecrucial importance of dendritic cells in psoriasis pathogenesis. This review will summarize and discuss the dendritic cellsubsets of the human skin and their pathophysiologicalinvolvement in psoriasis based on mouse- and patient-oriented studies.
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