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언어장애와 서맥으로 발현한 항NMDA수용체뇌염

Anti-NMDA Receptor Encephalitis Presenting with Language Impairment and Bradycardia

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초록

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is known to have various clinical symptoms, but usually shows acute behavioral changes, memory deficit, speech problems and dysregulation of autonomic nervous system. Recently, it has been found that NMDA receptors perform important roles not only in central nervous system but also in peripheral organs, like control the cardiac rhythm by located in the myocardium and cardiac conduction system. The authors would like to report a case of bradycardia accompanied by anti-NMDA receptor encephalitis.

Abstract

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is known to have various clinical symptoms, but usually shows acute behavioral changes, memory deficit, speech problems and dysregulation of autonomic nervous system. Recently, it has been found that NMDA receptors perform important roles not only in central nervous system but also in peripheral organs, like control the cardiac rhythm by located in the myocardium and cardiac conduction system. The authors would like to report a case of bradycardia accompanied by anti-NMDA receptor encephalitis.

참고문헌 (8)

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  3. Soda T, "The emerging role of N-methyl-D-aspartate(NMDA)receptors in the cardiovascular system : physiological implications, pathological consequences, and therapeutic perspectives", Int J Mol Sci, 24, pp.3914~ (2023)
  4. Mehr SR, "Profound autonomic instability complicated by multiple episodes of cardiac asystole and refractory bradycardia in a patient with anti-NMDA encephalitis", Case Rep Neurol Med, 2016, pp.7967526~ (2016)
  5. Sansing LH, "A patient with encephalitis associated with NMDA receptor antibodies", Nat Clin Pract Neurol, 3, pp.291~296 (2007)
  6. Oppenheimer S, "The insular cortex and the pathophysiology of stroke-induced cardiac changes", Can J Neurol Sci, 19, pp.208~211 (1992)
  7. Aleksandrov V, "The role of the insular cortex in the control of visceral functions", Human Physiology, 41, pp.553~561 (2015)
  8. Xie D, "Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes", Cell Res, 31, pp.951~964 (2021)

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