Anti-NMDA 수용체 뇌염
Anti-NMDA Receptor Encephalitis
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참고문헌
키워드
초록
A severe, but reversible encephalitis associated with antibodies to the N-methyl-D-aspartate receptor (NMDAR) was identified recently in young women with ovarian teratoma. This condition has not been reported previously in Korea. A 31-year-old woman presented with fever and behavioral disturbances; she became comatose several days later, and dyskinesia and dysautonomia developed thereafter. Antibodies to the NMDAR were positive and abdominal computed tomography detected a large ovarian teratoma. The patient improved dramatically after the removal of the teratoma and administration of corticosteroid therapy.
Abstract
A severe, but reversible encephalitis associated with antibodies to the N-methyl-D-aspartate receptor (NMDAR) was identified recently in young women with ovarian teratoma. This condition has not been reported previously in Korea. A 31-year-old woman presented with fever and behavioral disturbances; she became comatose several days later, and dyskinesia and dysautonomia developed thereafter. Antibodies to the NMDAR were positive and abdominal computed tomography detected a large ovarian teratoma. The patient improved dramatically after the removal of the teratoma and administration of corticosteroid therapy.
참고문헌 (10)
- Dalmau J, "Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies", Lancet Neurol, 7, pp.1091~1098 (2008)
- 김성헌, "A case of paraneoplastic limbic encephalitis due to ovarian mature teratoma", Korean Journal of Pediatrics, 53(4), pp.603~606 (2010), 대한소아과학회
- Lynch DR, "N-metnhy-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents", Mol Pharmacol, 45, pp.540~545 (1994)
- Waxman EA, "N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease", Neuroscientist, 11, pp.37~49 (2005)
- Coyle JT, "Glutamate and schizophrenia: beyond the dopamine hypothesis", Cell Mol Neurobiol, 26, pp.365~384 (2006)
- Manahan-Vaughan D, "A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats", Hippocampus, 18, pp.125~134 (2008)
- McCarron MM, "Acute phencyclidine intoxication: incidence of clinical findings in 1,000 cases", Ann Emerg Med, 10, pp.237~242 (1981)
- Irani SR, "N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes", Brain, 133, pp.1655~1667 (2010)
- Mais V, "Transvaginal ultrasonography in the diagnosis of cystic teratoma", Obstet Gynecol, 85, pp.48~52 (1995)
- Dalmau J, "Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma", Ann Neurol, 61, pp.25~36 (2007)