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B형 간염 건강 보균자인 노인에서 장기간 저용량 Methotrexate (MTX) 투약으로 발생한 간 경변증 1예

Development of Liver Cirrhosis in a Elderly Healthy Hepatitis B Carrier with Rheumatoid Arthritis Treated with Low-dose Methotrexate (MTX)

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키워드

주제분류가정의학

초록

Methotrexate (MTX)는 류마티스 관절염 치료에 효과적인 약물이나 장기간 사용한 경우 간 섬유화나 간 경변증을 초래 할 수 있다고 알려져 있다. 그러나 저용량을 사용하는 경우는 약의 부작용을 줄이면서도 좋은 효과를 볼 수 있어 안전하고 효과적인 치료법으로 알려져 있다. 그러나 만성 바이러스 보균자의 경우는 저용량의 투여라도 바이러스의 재활성화가 유발되어 전격성 간손상으로 발생한 증례들이 외국에서 보고되어 왔다. 본 저자들은 B형 간염 건강 보균자인 노인에게 류마티스 관절염 치료를 위하여 장기간의 저용량 MTX 투약 요법 후, 바이러스의 재활성화 없이 발생한 간 경변증 1예를 경험하여 증례를 보고하는 바이다.

Abstract

Development of Liver Cirrhosis in a Elderly Healthy Hepatitis B Carrier with Rheumatoid Arthritis Treated with Low-dose Methotrexate (MTX)Mi Hee Kong, M.D., Tae Young Lee, M.D., A Ryn Kim, M.D., Nam Seok Joo, M.D., Kwang Min Kim, M.D.†

참고문헌 (21)

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