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만성 B 형 간염 환자에서 HBsAg 혈청clearance의 사례보고

A Case Report of HBsAg Seroclearance in Chronic Hepatitis B Patient

이민혁|이혁재
대한임상검사과학회 (Korean Society for Clinical Laboratory Science)|2012.09|대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)|제44권 제3호|pp. 142-146

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Abstract

Hepatitis B surface antigen (HBsAg) seroclearance is a rare event in chronic hepatitis B virus (HBV) infection which acquires the disease early in life. A case study have examined with asymptomatic chronic hepatitis B carrier who exhibits HBsAg seroclearance in anti-HBe positive. We comprehensively studied the biochemical, virological and clinical aspects of a patient with HBsAg seroclearance. Liver biochemistry, serological markers, serum HBV DNA levels, and development of clinical complications were monitored. Mutation of hepatitis B virus is suspected serum HBsAg detected by the HBsAg assay systems of VITROS (OrthoClinical Diagnostics, USA), AxSYM (Abbott Laboratories, USA), Elecsys (Roche Diagnostics, Germany) and ADVIA Centaur (Bayer Diagnostics, USA). These four immunoassays showed negative results. Also, the patient had undetectable serum HBV DNA. Therefore, no mutation within the “a” determinant of HBsAg, which might escape detection from HBsAg immunoassay were found. Natural seroclearance was confirmed.

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관련 논문AI추천

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