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A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier

은창수|전용철|Hye Sun Park|손주현|Joong Ho Bae|Hye Soon Lee|Yil Sik Hyun|Tae Yeob Kim|Dong Soo Han
대한간학회 (The korean Association for the Study of the Liver)|2012.06|Clinical and Molecular Hepatology|제18권 제2호|pp. 225-228

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키워드

SteroidsHepatitis B virusVirus activationLiver failure

초록

Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-term, very-low-dose (2.5 mg/day) steroid treatment for rheumatoid arthritis. We suggest that even a minimal dose of single-regimen oral steroid can cause reactivation of indolent, inactive HBV. (Clin Mol Hepatol 2012;18:225-228)

Abstract

Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-term, very-low-dose (2.5 mg/day) steroid treatment for rheumatoid arthritis. We suggest that even a minimal dose of single-regimen oral steroid can cause reactivation of indolent, inactive HBV. (Clin Mol Hepatol 2012;18:225-228)

참고문헌 (19)

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