본문 바로가기
KERD
논문KCI 등재

식물의 감수분열에서 상동 재조합 효소 특이 기능의 연구현황 및 전망

Current status and prospects of the meiosis-specific function of recombinase in plants

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류농학

초록

Meiosis is a specialized cell division, essential in most reproducing organisms to halve the number of chromosomes, thereby enabling the restoration of ploidy levels during fertilization. A key step in meiosis is homologous recombination, which promotes homologous pairing and generates crossovers (COs) to connect homologous chromosomes until their separation at anaphase I. These CO sites, seen cytologically as chiasmata, represent a reciprocal exchange of genetic information between two homologous non-sister chromatids. RAD51, the eukaryotic homolog of the bacterial RecA recombinase, plays a central role in homologous recombination (HR) in yeast and animals. Loss of RAD51 function causes lethality in the flowering plant, Arabidopsis thaliana, suggesting that RAD51 has a meiotic stage-specific function that is different from homologous pairing activity.

Abstract

Meiosis is a specialized cell division, essential in most reproducing organisms to halve the number of chromosomes, thereby enabling the restoration of ploidy levels during fertilization. A key step in meiosis is homologous recombination, which promotes homologous pairing and generates crossovers (COs) to connect homologous chromosomes until their separation at anaphase I. These CO sites, seen cytologically as chiasmata, represent a reciprocal exchange of genetic information between two homologous non-sister chromatids. RAD51, the eukaryotic homolog of the bacterial RecA recombinase, plays a central role in homologous recombination (HR) in yeast and animals. Loss of RAD51 function causes lethality in the flowering plant, Arabidopsis thaliana, suggesting that RAD51 has a meiotic stage-specific function that is different from homologous pairing activity.

참고문헌 (59)

  1. Aboussekhra A, "Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins", Mol Cell Biol, 12, pp.3224~3234 (1992)[DOI]
  2. Aihara H, "The N-terminal domain of the human Rad51 protein binds DNA: structure and a DNA binding surface as revealed by NMR", J Mol Biol, 290, pp.495~504 (1999)[DOI]
  3. Allers T, "Differential timing and control of noncrossover and crossover recombination during meiosis", Cell, 106, pp.47~57 (2001)[DOI]
  4. Basile G, "Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51", Mol Cell Biol, 12, pp.3235~3246 (1992)[DOI]
  5. Baumann P, "Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro", Cell, 87, pp.757~766 (1996)[DOI]
  6. Benson FE, "Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA", EMBO J, 13, pp.5764~5771 (1994)
  7. Bishop DK, "DMC1: a meiosisspecific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression", Cell, 69, pp.439~456 (1992)[DOI]
  8. Bugreev DV, "Activation of human meiosis-specific recombinase Dmc1 by Ca2+", J Biol Chem, 280, pp.26886~22695 (2005)[DOI]
  9. Bugreev DV, "The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis", Nat Struct Mol Biol, 18, pp.56~60 (2011)[DOI]
  10. Busygina V, "Hed1 regulates Rad51-mediated recombination via a novel mechanism", Genes Dev, 22, pp.786~795 (2008)[DOI]
  11. Chen J, "Insights into the mechanism of Rad51 recombinase from the structure and properties of a filament interface mutant", Nucleic Acids Res, 38, pp.4889~4906 (2010)[DOI]
  12. Chen Z, "Mechanism of homologous recombination from the RecA-ssDNA", dsDNA structures, 2008, pp.453, 489~494
  13. Cloud V, "Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis", Science, 337, pp.1222~1225 (2012)[DOI]
  14. Cole F, "Homeostatic control of recombination is implemented progressively in mouse meiosis", Nat Cell Biol, 4, pp.424~430 (2012)
  15. Conway AB, "Crystal structure of a Rad51 filament", Nat Struct Mol Biol, 11, pp.791~796 (2004)[DOI]
  16. Da Ines O, "Meiotic recombination in Arabidopsis is catalysed by DMC1, with RAD51 playing a supporting role", PLoS Genet, 9, pp.e1003787~ (2013)
  17. Fraune J, "The mammalian synaptonemal complex: protein components, assembly and role in meiotic recombination", Exp Cell Res, 318, pp.1340~1346 (2012)[DOI]
  18. Gupta RC, "Activities of human recombination protein Rad51", Proc Natl Acad Sci USA, 94, pp.463~468 (1997)[DOI]
  19. Habu T, "The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis", Nucleic Acids Res, 24, pp.470~477 (1996)[DOI]
  20. Hikiba J, "Structural and functional analyses of the DMC1-M200V polymorphism found in the human population", Nucleic Acids Res, 36, pp.4181~4190 (2008)[DOI]
  21. Kagawa W, "From meiosis to postmeiotic events: uncovering the molecular roles of the meiosis-specific recombinase Dmc1", FEBS J, 277, pp.590~598 (2010)
  22. Keeney S, "Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis", Genome Dyn Stab, 2, pp.81~123 (2008)
  23. Keeney S, "Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family", Cell, 88, pp.375~384 (1997)[DOI]
  24. Kurumizaka H, "A possible role of the C-terminal domain of the RecA protein", J Biol Chem, 271, pp.33515~33524 (1996)
  25. Kurumizaka H, "The mutant RecA proteins, RecAR243Q and RecAK245N, exhibit defective DNA binding in homologous pairing", Arch Biochem Biophys, 365, pp.83~91 (1999)[DOI]
  26. Lim DS, "Mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53", Mol Cell Biol, 16, pp.7133~7143 (1996)[DOI]
  27. Liu Y, "Down-regulation of Rad51 activity during meiosis in yeast prevents competition with Dmc1 for repair of double-strand breaks", PLoS Genet, 10, pp.e1004005~ (2014)[DOI]
  28. Maeshima K, "Purification and characterization of XRad51.1 protein, Xenopus RAD51 homologue: recombinant XRad51.1 promotes strand exchange reaction", Genes Cells, 1, pp.1057~1068 (1996)[DOI]
  29. Mandon-Pepin B, "Human infertility: meiotic genes as potential candidates", Gynecol. Obstet Fertil., 30, pp.817~821 (2002)[DOI]
  30. Mandon-Pepin B, "Genetic investigation of four meiotic genes in women with premature ovarian failure", European J Endocrinol, 158, pp.07~115 (2008)
  31. Masson JY, "The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51", EMBO J, 8, pp.6552~6560 (1999)
  32. Matsuo Y, "Roles of the human Rad51 L1 and L2 loops in DNA binding", FEBS J, 273, pp.3148~3159 (2006)[DOI]
  33. Mimitou EP, "Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing", Nature, 455, pp.770~774 (2008)[DOI]
  34. Nassif N, "Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair", Mol Cell Biol, 14, pp.1613~1625 (1994)[DOI]
  35. Neale MJ, "Clarifying the mechanics of DNA strand exchange in meiotic recombination", Nature, 442, pp.153~158 (2006)
  36. Niu H, "Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation", Mol Cell, 36, pp.393~404 (2009)[DOI]
  37. Ogawa T, "Similarity of the yeast RAD51 filament to the bacterial RecA filament", Science, 259, pp.1896~1899 (1993)[DOI]
  38. Passy SI, "Human Dmc1 protein binds DNA as an octameric ring", Proc Natl Acad Sci USA, 96, pp.10684~10688 (1999)[DOI]
  39. Petronczki M, "Un menage a quatre: the molecular biology of chromosome segregation in meiosis", Cell, 112, pp.423~440 (2003)[DOI]
  40. Pittman DL, "Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog", Mol Cell, 1, pp.697~705 (1998)[DOI]
  41. Renkawitz J, "Mechanisms and principles of homology search during recombination", Nat Rev. Mol Cell Biol, 15, pp.369~383 (2014)
  42. Reymer A, "Structure of human Rad51 protein filament from molecular modeling and site-specific linear dichroism spectroscopy", Proc Natl Acad Sci USA, 106, pp.13248~13253 (2009)
  43. Roeder GS, "Meiotic chromosomes: it takes two to tango", Genes Dev, 15, pp.2600~2621 (1997)
  44. Sakane I, "Filament formation and robust strand exchange activities of the rice DMC1A and DMC1B proteins", Nucleic Acids Res, 6, pp.4266~4276 (2008)
  45. San Filippo J, "Mechanism of eukaryotic homologous recombination", Annu Rev Biochem, 77, pp.229~257 (2008)[DOI]
  46. Schwacha A, "Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway", Cell, 190, pp.1123~1135 (1997)
  47. Sehorn MG, "Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange", Nature, 429, pp.433~437 (2004)[DOI]
  48. Shinohara A, "Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein", Cell, 69, pp.457~470 (1992)[DOI]
  49. Shinohara A, "Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA", Nat Genet, 4, pp.239~243 (1993)[DOI]
  50. Shinohara M, "Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis", Nat Genet, 40, pp.299~309 (2008)[DOI]
  51. Sonoda E, "Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death", EMBO J, 17, pp.598~608 (1998)[DOI]
  52. Sung P, "Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein", Science, 265, pp.1241~1243 (1994)[DOI]
  53. Symington L S, "Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair", Microbiol Mol Biol Rev, 66, pp.630~670 (2002)[DOI]
  54. Szostak JW, "The double-strand-break repair model for recombination", Cell, 33, pp.25~35 (1983)[DOI]
  55. Tsuzuki T, "Targeted disruption of the Rad51 gene leads to lethality in embryonic mice", Proc Natl Acad Sci USA, 93, pp.6236~6240 (1996)[DOI]
  56. West SC, "Molecular views of recombination proteins and their control", Nat Rev Mol Cell Biol, 4, pp.435~445 (2003)
  57. Yoshida K, "The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis", Mol Cell, 1, pp.707~718 (1998)[DOI]
  58. Yu X, "Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA", Proc Natl Acad Sci USA, 98, pp.8419~8424 (2001)[DOI]
  59. Zhou Y, "Quantitation of DNA double-strand break resection intermediates in human cells", Nucleic Acids Res, 42, pp.e19~ (2014)[DOI]

관련 논문AI추천

이 간행물의 다른 논문 (9건)