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Synthesis, Physico-Chemical and Biological Properties of Complexes of Cobalt(II) Derived from Hydrazones of Isonicotinic Acid Hydrazide

Ram K. Agarwal|Surendra Prasad
대한화학회|2009.02|대한화학회지 (Journal of the Korean Chemical Society)|제53권 제1호|pp. 17-26

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참고문헌

키워드

CharacterizationBiological activity생물활성코발트(II)Cobalt(II)Complexes착물Hydrazones특성규명
주제분류화학

초록

Hydrazones of isonicotinic acid hydrazide, viz., N-isonicotinamido-furfuralaldimine (INH-FFL), N-isonicotnamido-cinnamalidine (INH-CIN) and N-isonicotnamido-3',4',5'-trimethoxybenzaldimine (INH-TMB) were prepared by reacting isonicotinic acid hydrazide with respective aromatic aldehydes, i.e., furfural, cinnamaldehyde or 3,4,5-trimethoxy-benzaldehyde. A new series of fifteen complexes of cobalt(II) with these new hydrazones, INH-FFL, INH-CIN and INH-TMB, were synthesized by their reaction with cobalt(II) salts. The infrared spectral data reveal that hydrazone ligands behave as a bidentate ligand with N, O donor sequence towards the Co2+ ion. The complexes were characterized on the basis of elemental analysis, magnetic susceptibility, conductivity, infrared and electronic spectral measurements. Analytical data reveal that the complexes have general composition [Co(L)2X2] and [Co(L)3](ClO4)2 where L= INH-FFL, INH-CIN or INH-TMB and X = Cl–,NO3 –, NCS– or CH3COO–. The thermal behaviour of the complexes were studied using thermogravimetrictechnique. Electronic spectral results and magnetic susceptibility measurements are consistent with the adoption of a six-coordinate geometry for the cobalt(II) chelates. The antimicrobial properties of cobalt(II) complexes and few standard drugs have revealed that the complexes have very moderate antibacterial activities.

Abstract

Hydrazones of isonicotinic acid hydrazide, viz., N-isonicotinamido-furfuralaldimine (INH-FFL), N-isonicotnamido-cinnamalidine (INH-CIN) and N-isonicotnamido-3',4',5'-trimethoxybenzaldimine (INH-TMB) were prepared by reacting isonicotinic acid hydrazide with respective aromatic aldehydes, i.e., furfural, cinnamaldehyde or 3,4,5-trimethoxy-benzaldehyde. A new series of fifteen complexes of cobalt(II) with these new hydrazones, INH-FFL, INH-CIN and INH-TMB, were synthesized by their reaction with cobalt(II) salts. The infrared spectral data reveal that hydrazone ligands behave as a bidentate ligand with N, O donor sequence towards the Co2+ ion. The complexes were characterized on the basis of elemental analysis, magnetic susceptibility, conductivity, infrared and electronic spectral measurements. Analytical data reveal that the complexes have general composition [Co(L)2X2] and [Co(L)3](ClO4)2 where L= INH-FFL, INH-CIN or INH-TMB and X = Cl–,NO3 –, NCS– or CH3COO–. The thermal behaviour of the complexes were studied using thermogravimetrictechnique. Electronic spectral results and magnetic susceptibility measurements are consistent with the adoption of a six-coordinate geometry for the cobalt(II) chelates. The antimicrobial properties of cobalt(II) complexes and few standard drugs have revealed that the complexes have very moderate antibacterial activities.

참고문헌 (40)

  1. Prasad, S, , Trans. Metal Chem, 32, pp.143~ (2007)
  2. Agarwal, R. K, , Bioinorg. Chem. Appl, 3, pp.271~ (2005)
  3. Prasad,S, , Res. Lett. Inorg Chem, 1, pp.1~ (2008)
  4. Agarwal, R. K, , Turk. J. Chem., 28, pp.691~ (2004)
  5. Agarwal, R. K, , Revs. Inorg. Chem., 26, pp.471~ (2006)
  6. Agarwal, R. K, , Turkish J. Chem., 29, pp.289~ (2005)
  7. Agarwal, R. K, , Trans. Metal Chem., 30, pp.696~ (2005)
  8. Agarwal, R. K, , Turk. J. Chem., 29, pp.309~ (2005)
  9. Agarwal, R. K, , Polish J. Chem., 67, pp.581~ (1993)
  10. Murukan, B, , Trans. Metal Chem., 31, pp.441~ (2006)
  11. Tumer, M., , Spectrochim. Acta A: Mol. Biomol. Spectrosc., 66, pp.1271~ (2007)
  12. Tumer, M, , Trans. Metal Chem., 31, pp.1~ (2006)
  13. Pandey, G, , Bioinorg. Chem. Appl., 3, pp.217~ (2005)
  14. Sharaby, C.M, , Spectrochim. Acta A: Mol. Biomol. Spectrosc., 66, pp.1271~ (2007)
  15. Mohamed, G.C, , Spectrochim. Acta A: Mol. Biomol. Spectrosc, 66, pp.949~ (2007)
  16. Ashok, M, , J. Braz. Chem. Soc., 26, pp.204~ (2007)
  17. Ferrari, M.B, , J. Inorg. Biochem, 70, pp.145~ (1998)
  18. Srivastava, A.K, , Bioinorg. Chem. Appl., 3, pp.289~ (2005)
  19. Chandra, S, , Spectrochim. Acta A: Mol. Biomol. Spectrosc., 66, pp.1347~ (2007)
  20. Kilpin, K.J, , Polyhedran, 26, pp.204~ (2007)
  21. Sharma, R.P, , Ind. J. Derm. Vener. Lepr., 61, pp.261~ (1995)
  22. Bassett, J, "Vogel’s Text Book of Quantitative Inorganic Analysis, 4th Ed" (1986), Longman Sc. Tech. Pub.
  23. Kurz, E, , Anal. Chem., 30, pp.1983~ (1958)
  24. Agarwal, R. K, , Polish J. Chem., 53, pp.393~ (1984)
  25. Agarwal, R. K, , Polyhedron, 12, pp.2411~ (1993)
  26. Agarwal, R. K, , Bull. Chem. Soc. Ethio., 9, pp.23~ (1995)
  27. Krishnan, P.S. R, , Indian J. Chem., 28A, pp.234~ (1989)
  28. Agarwal, R. K, , Polyhedron, 10, pp.2399~ (1991)
  29. Agarwal, R. K, , Polish J. Chem., 66, pp.899~ (1992)
  30. Burns, G.R, , Inorg. Chem, 7, pp.272~ (1968)
  31. Nakamoto, K, "Infrared Spectra of Inorganic and Coordination Compounds" (1970), Willey
  32. Bailey, R.A, , J. Inorg. Nucl. Chem., 33, pp.3206~ (1971)
  33. Burmeister, J.L, , Coord. Chem. Rev., 105, pp.77~ (1990)
  34. Bailey, R.A, , Coord. Chem. Rev., 6, pp.407~ (1971)
  35. Addison, C.C, , Quart. Chem. Rev., 25, pp.289~ (1971)
  36. Lever, A.B.P, , Canad. J. Chem., 49, pp.1957~ (1971)
  37. Ahuja, I.S, , Asian J. Chem., 1, pp.195~ (1989)
  38. Thomas, J, , Asian J. Chem, 14, pp.1354~1370 (2002)
  39. Lever, A.B.P, , J. Chem. Edu., 45, pp.711~
  40. Reedijk, J, , Recl. Trav. Chim., 88, pp.1095~ (1968)

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