Synthesis, Antibacterial and Antifungal Activities of Some Cobalt(II) and Nickel(II) Complexes of Thiosemicarbazones
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
In the present paper two new thiosemicarbazones i.e., 4[N-(4'-ethylbenzalidene)amino]antipyrine thiosemicarbazone (EBAAPTS) and 4[N-(2',4'-dimethylbenzalidene)amino]antipyrine thiosemicarbazone (DMBAAPTS) have been synthesized and characterized. The complexing abilities of these thiosemicarbazones i.e. EBAAPTS and DMBAAPTS towards cobalt(II) and nickel(II) salts have been explored. The reactions of the hot ethanolic solutions of cobalt(II) and nickel(II) salts with EBAAPTS and DMBAAPTS led to the formation of the novel complexes of general composition [MX_2(L)H_2O] (M=Co^(2+) or Ni^(2+); X=Cl^–, Br^–, NO_3^–, NCS^– or CH_3COO^–; L=EBAAPTS or DMBAAPTS). The newly synthesized complexes have been characterized by elemental analyses, molar mass, molar conductance, magnetic susceptibility, infrared and electronic spectral studies. The molar conductance measurements of the complexes in nitrobenzene correspond to their non-electrolytic nature. All the complexes are of high-spin type. On the basis of spectral studies an octahedral geometry has been assigned for Co(II) and Ni(II) complexes of the type [MX_2(L)H_2O]. These complexes were screened for their antibacterial and antifungal activities on different species of pathogens, fungi and bacteria and their biopotency has been discussed.
Abstract
In the present paper two new thiosemicarbazones i.e., 4[N-(4'-ethylbenzalidene)amino]antipyrine thiosemicarbazone (EBAAPTS) and 4[N-(2',4'-dimethylbenzalidene)amino]antipyrine thiosemicarbazone (DMBAAPTS) have been synthesized and characterized. The complexing abilities of these thiosemicarbazones i.e. EBAAPTS and DMBAAPTS towards cobalt(II) and nickel(II) salts have been explored. The reactions of the hot ethanolic solutions of cobalt(II) and nickel(II) salts with EBAAPTS and DMBAAPTS led to the formation of the novel complexes of general composition [MX_2(L)H_2O] (M=Co^(2+) or Ni^(2+); X=Cl^–, Br^–, NO_3^–, NCS^– or CH_3COO^–; L=EBAAPTS or DMBAAPTS). The newly synthesized complexes have been characterized by elemental analyses, molar mass, molar conductance, magnetic susceptibility, infrared and electronic spectral studies. The molar conductance measurements of the complexes in nitrobenzene correspond to their non-electrolytic nature. All the complexes are of high-spin type. On the basis of spectral studies an octahedral geometry has been assigned for Co(II) and Ni(II) complexes of the type [MX_2(L)H_2O]. These complexes were screened for their antibacterial and antifungal activities on different species of pathogens, fungi and bacteria and their biopotency has been discussed.
참고문헌 (45)
- Prasad, S., , Trans. Metal Chem, 32, pp.143~ (2007)
- Agarwal, R. K., , Bioinorg. Chem. Appl, 33, pp.271~ (2005)
- Prasad, S., , Res. Lett. Inorg Chem, 1, pp.350921~ (2008)
- Agarwal, R. K., , Turk. J. Chem, 28, pp.691~ (2004)
- Agarwal, R. K., , Inorg. Chem, 26, pp.471~ (2006)
- Agarwal, R. K., , Turkish J. Chem, 29, pp.289~ (2005)
- Agarwal, R. K., , Trans. Metal Chem, 30, pp.696~ (2005)
- Agarwal, R. K., , Turk. J. Chem, 29, pp.309~ (2005)
- Agarwal, R. K., , Polish J. Chem, 67, pp.581~ (1993)
- Surendra Prasad, "Synthesis, Physico-Chemical and Biological Properties of Complexes of Cobalt(II) Derived from Hydrazones of Isonicotinic Acid Hydrazide", 대한화학회지, 53(1), pp.17~26 (2009), 대한화학회
- Surendra Prasad, "Synthesis, Magneto-Spectral, Electrochemical, Thermal Characterization and Antimicrobial Investigations of Some Nickel(II) Complexes of Hydrazones of Isoniazid", 대한화학회지, 53(6), pp.683~692 (2009), 대한화학회
- Murukan, B., , Trans. Metal Chem, 31, pp.441~ (2006)
- Tumer, M., , Spectrochim. Acta A: Mol. Biomol. Spectrosc, 66, pp.1271~ (2007)
- Tumer, M., , Trans. Metal Chem, 31, pp.1~ (2006)
- Pandey, G., , Bioinorg. Chem. Appl, 3, pp.217~ (2005)
- Sharaby, C. M., , Spectrochim. Acta A: Mol. Biomol. Spectrosc, 66, pp.1271~ (2007)
- Mohamed, G. C., , Spectrochim. Acta A: Mol. Biomol. Spectrosc, 66, pp.949~ (2007)
- Ashok, M., , Braz. Chem. Soc, 26, pp.204~ (2007)
- Ferrari, M. B., , J. Inorg. Biochem, 70, pp.145~ (1998)
- Srivastava, A. K., , Bioinorg. Chem. Appl, 3, pp.289~ (2005)
- Chandra, S., , Spectrochim. Acta A: Mol. Biomol. Spectrosc, 66, pp.1347~ (2007)
- Kilpin, K. J., , Polyhedron, 26, pp.204~ (2007)
- Lewis A., "Medicinal Chemistry", pp.431~ (1970), Wiley
- Klaymann, D. L., , Eur. J. Med. Chem. (Theor.), 16, pp.317~ (1981)
- Shipman (Jr.), C., , Antimicrol. Agents Chemother, 19, pp.682~ (1981)
- Agarwal, R. K., , J. Inst. Chem. (India), 65, pp.131~ (1993)
- Geary, W. J., , Coord. Chem. Rev, 7, pp.110~ (1971)
- Agarwal, R. K., , Polish. J. Chem, 65, pp.1211~ (1991)
- Rana, V. B., , J. Inorg. Nucl. Chem, 37, pp.1826~ (1975)
- Ferraro, J. R., "Low Frequency Vibrations of Inorganic and Coordination Compounds" (1971), Plenum
- Burmeister, J. L., , Coord. Chem. Rev, 1, pp.205~ (1966)
- Addison, C. C., , Quart. Chem. Rev, 25, pp.289~ (1971)
- Lever, A. B. P., , Can. J. Chem, 49, pp.1957~ (1971)
- Almja, I. S., , Asian J. Chem, 1, pp.195~ (1989)
- Lever, A. B. P., , J. Chem. Soc, pp.4751~ (1964)
- Padhye, S., , Coord. Chem. Revs, 63, pp.127~ (1985)
- Thomas J., , Asian J. Chem, 14, pp.1354~ (2002)
- Murthy, N., , Asian J. Chem, 14, pp.1325~ (2002)
- Taylor, M. R., , Bioinorg. Chem, 3, pp.89~ (1994)
- Ferrari, M. B., , J. Inorg. Biochem, 53, pp.13~ (1994)
- Ferrari, M. B., , J. Inorg. Biochem, 70, pp.145~ (1998)
- Murukan, B., , Trans. Metal Chem, 31, pp.441~ (2006)
- Tumer, M., , Spectrochim. Acta A: Mol. Biomol. Spectrosc, 67, pp.916~ (2007)
- El-Ayaam, U., , Euro. J. Med. Chem, 40, pp.1214~ (2005)
- Al-Bari, M. A. A., , J. Appl. Scs. Res, 3, pp.1251~ (2007)