비알코올성 지방간과 대사증후군 및 혈청 카로테노이드와의 관련성
Associations of Non Alcoholic Fatty Liver with the Metabolic Syndrome and Serum Carotenoids
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Objectives : This study was conducted to investigate the associations of non alcoholic fatty liver with metabolic syndrome and the serum carotenoids. Methods : This study was conducted in a general hospital in South Korea from November, 2004 to August, 2005. The study subjects were 350 sampled persons who were aged from 40 years and older (males: 180, females: 170). They were grouped into the normal, mild and severe groups according to fat accumulation in their livers, as determined by ultrasonography. We analyzed the association between non alcoholic fatty liver and metabolic syndrome by multiple logistic regression analysis and we analyzed the association between non alcoholic fatty liver and the serum carotenoids by a general linear model(ANCOVA). Results : After adjustment for the effect of potential covariates, the prevalence of metabolic syndrome was associated with fat accumulation in the liver (p trend <0.001). If the odds ratio of normal group is 1.00, then that of the mild group is 2.80 (95% C.I=1.17-6.71) and that of the severe group is 7.29 (95% C.I=2.76-19.30). The prevalence of metabolic alterations fitting the criteria of metabolic syndrome, according to the class of fat accumulation in the liver, was significantly increased, except for criteria of high blood pressure, a large waist circumference and low HDL (high density lipoprotein) cholesterol level (p trend <0.001). The level of serum S- carotene was decreased according to the class of fat accumulation in the liver (p trend=0.036), but the levels of serum T-carotene, lycopene, S-cryptoxanthin and lutein were not decreased. Conclusions : This study shows that non alcoholic fatty liver was associated with metabolic syndrome and with the serum S-carotene level.
Abstract
Objectives : This study was conducted to investigate the associations of non alcoholic fatty liver with metabolic syndrome and the serum carotenoids. Methods : This study was conducted in a general hospital in South Korea from November, 2004 to August, 2005. The study subjects were 350 sampled persons who were aged from 40 years and older (males: 180, females: 170). They were grouped into the normal, mild and severe groups according to fat accumulation in their livers, as determined by ultrasonography. We analyzed the association between non alcoholic fatty liver and metabolic syndrome by multiple logistic regression analysis and we analyzed the association between non alcoholic fatty liver and the serum carotenoids by a general linear model(ANCOVA). Results : After adjustment for the effect of potential covariates, the prevalence of metabolic syndrome was associated with fat accumulation in the liver (p trend <0.001). If the odds ratio of normal group is 1.00, then that of the mild group is 2.80 (95% C.I=1.17-6.71) and that of the severe group is 7.29 (95% C.I=2.76-19.30). The prevalence of metabolic alterations fitting the criteria of metabolic syndrome, according to the class of fat accumulation in the liver, was significantly increased, except for criteria of high blood pressure, a large waist circumference and low HDL (high density lipoprotein) cholesterol level (p trend <0.001). The level of serum S- carotene was decreased according to the class of fat accumulation in the liver (p trend=0.036), but the levels of serum T-carotene, lycopene, S-cryptoxanthin and lutein were not decreased. Conclusions : This study shows that non alcoholic fatty liver was associated with metabolic syndrome and with the serum S-carotene level.
참고문헌 (24)
- Falck-Ytter Y., "Clinical features and natural history of nonalcoholic steatosis syndrome", Semin Liver Dis, 21(1), pp.17~26 (2001)
- Clark J.M., "Nonalcoholic fatty liver disease", Gastroenterology, 122(6), pp.1649~1657 (2002)
- Hoyumpa A.M. Jr., "Fatty Liver: Biochemical and clinical considerations", Am J Dig Dis, 20(12), pp.1142~1170 (1975)
- Isselbacher K.J., "Infiltrative and metabolic disease affecting the liver, Harrison’s Principle of Internal Medicine", pp.1352~1355 (1991), McGraw-Hill
- Sung NE, "Obesity and dietary habit", J Korean Med Assoc, 32(5), pp.502~506 (1989)
- Esterbauer H., "Chemistry and biochemistry of 4-hydroxynonenal, malonal-dehyde and related aldehydes", Free Radic Biol Med, 11(1), pp.81~128 (1991)
- Saibara T., "NASH and metabolic syndrome. Nippon Rinsho", 64(6), pp.1165~1167 (2006)
- Marchesini G., "Nonalcoholic fatty liver disease and the metabolic syndrome", Minerva Cardioangiol, 54(2), pp.229~239 (2006)
- Hwang S.W., "Association of Nonalcoholic fatty liver disease with metabolic syndrome over 65 years elderly", J Korean Geriatr Soc, 8(2) (2004)
- 문기원, "비알코올성 지방간 환자에서 대사증후군의 유병률", 대한간학회지, 10(2004), pp.197~206 (2004), 대한간학회
- 박경식, "비알콜성 지방간염에서 항산화 상태", 대한간학회지, 11(2005), pp.135~143 (2005), 대한간학회
- Chalasani N., "Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis", Am J Gastroenterol, 99(8), pp.1497~1502 (2004)
- Letteron P., "Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice", J Hepatol, 24(2), pp.200~208 (1996)
- Bieri J.G., "Simultaneous determination of T-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography", Am J Clin Nutr, 32(10), pp.2143~2149 (1979)
- "The Asia-pacific perspective: Redefining obesity and its treatment"[URL]
- Song J.H., "Meatbolic syndrome and its alternative definition for prevalent diabetes mellitus in Korean population: The Ansan study", Korean J Lipidol, 13(1), pp.9~12 (2003)
- Earl S., "Prevalence of the metabolic syndrome among US adults: Findings from the third national health and nutrition examination survey", JAMA, 287(3), pp.356~359 (2002)
- Lombardi B., "Considerations on the pathogenesis of fatty liver", Lab Invest, 15(1), pp.1~20 (1966)
- Furukawa S., "Increased oxidative stress in obesity and its impact on metabolic syndrome", J Clin Invest, 114(12), pp.1752~1761 (2004)
- Fujita K., "Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome", Circ J, 70(11), pp.1437~1442 (2006)
- Bahcecioglu I.H., "Levels of serum vitamin A, alpha-tocopherol and malondialdehyde in patients with non-alcoholic steatohepatitis: Relationship with histopathologic severity", Int J Clin Pract, 59(3), pp.318~323 (2005)
- Chae H.B., "Nonalcoholic fatty liver disease : A spectrum of clinical and sonographical severity", Chungbuk Med J, 10(1), pp.43~51 (2000)
- Ohm S.H., "A cross-sectional study on the risk factors related to fatty liver", J Prev Med Public Health, 26(2), pp.179~191 (1993)
- Ahn J.E., "A cross-sectional study on prevalence rate and contributing factors of fatty liver diagnosed by ultrasonography", J Prev Med Public Health, 24(2), pp.195~210 (1991)