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혈중 Carotenoids농도와 대사증후군의 관련성

Association between Serum Carotenoids and Metabolic syndrome

이건호|김성희|박계원
대한임상건강증진학회 (Korean Society For Health Promotion And Disease Prevention)|2009.12|Korean Journal of Health Promotion|제9권 제4호|pp. 314-320

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대사증후군metabolic syndromecardiovascular diseaseoxidative stressCarotenoidscarotenoids
주제분류기타자연과학

초록

연구배경 : 항산화제인 carotenoids와 심혈관질환 위험인자인 대사증후군의 관련성을 알아보고자 하였다. 방 법 : 2005년 9월-12월 사이, 일개 대학병원에서 40세 이상의 검강 검진 수검자 533명을 대상으로 대사증후군 및 위험요소에 따른 혈중 carotenoids 농도를 비교하고 (ANCOVA), carotenoids 농도가 대사증후군에 미치는 영향을 분석하였다(multiple logistic regression analysis). 통계분석은 SPSS 12.0을 이용하였으며, carotenoids 측정값은 나이, 성별, 흡연, 음주, 육체적 활동량, 과일 및 채소의 섭취량, 비타민 및 미네랄 보충제 복용량에 대해 보정하였다. 결 과 : 대사증후군에서 일부 혈중 carotenoids의 농도가 저하되었다(p<0.05). β-carotene은 대부분의 대사증후군 항목에서 유의한 농도저하를 보이고(p<0.05) 대사증후군 항목 수 증가에 따른 음의 용량-반응 관계가 있었으며(p<0.01), β-carotene농도 1사분위에서 대사증후군의 위험도가 5.35배 증가하였고(p<0.01). 복부비만이 동반된 대사증후군에서 농도가 가장 낮았다(p<0.01). 혈중 carotenoids 농도는 남자가 여자보다 낮게 측정되었다(Lutein 제외). 결 론 : 본 연구에서 carotenoids는 대사증후군을 예방하는 경향을 보이었으며 특히, β-carotene에서 유의하였다.

Abstract

Background : This study investigated the association between serum carotenoids as antioxidants and metabolic syndrome as a risk factor of cardiovascular disease. In addition, the relationships among oxidative stress, metabolic syndrome and antioxidants were assessed. Methods : From September to December, 533 subjects (>40 yrs, men: 342, women: 181) from one general hospital joined this study. They were grouped into: normal (460), metabolic syndrome without central obesity (13) and metabolic syndrome with central obesity (60). We analyzed associations among 1) serum carotenoids and metabolic syndrome considering central obesity and gender (ANCOVA), 2) serum carotenoids and the 5 components of metabolic syndrome (ANOVA, ANCOVA) and 3) serum carotenoids and risk factors for cardiovascular disease (correlation test) by SPSS 12.0. Serum carotenoid concentrations were adjusted for age, gender, smoking, alcohol use, physical activity, intake of fruits and vegetables and supplement use (vitamins and minerals). Results : Serum carotenoid levels were lower in the presence of metabolic syndrome, with the lowest levels seen in metabolic syndrome with central obesity. Serum levels of β-carotene were lower with most components of the metabolic syndrome and decreased according to increasing numbers of components (negative dose-response relationship, p<0.05). Conclusions : This study showed that serum carotenoids are associated with the metabolic syndrome.

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