농촌 지역 주민의 혈청 ferritin 수준과 대사증후군과의 관련성
Serum Ferritin and Risk of the Metabolic Syndrome in Some Korean Rural Residents
0
조회
0
다운로드
8
인용
0
참고문헌
키워드
초록
the relationship between serum ferritin and the metabolic syndrome (MS). Methods : We conducted a cross-sectional study of 1,444 adults over age 40 and under age 70 that lived in a rural area and participated in a survey conducted as part of the Korean Rural Genomic Cohort Study (KRGCS). The MS was defined as the presence of at least three of the followings: elevated blood pressure, low high density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, or abdominal obesity. After adjustment for age, alcohol intake, menopausal status, body mass index (BMI), high sensitivity C-reactive protein (hs-CRP), and alanine aminotransferase (ALT), odds ratios (ORs) for the prevalence of the MS by sex were calculated for quartiles of serum ferritin using logistic regression analysis. Results : The MS was more common in those persons with the highest levels of serum ferritin, compared to persons with the lowest levels, in men (37.1% vs. 22.4%, p=0.006) and women (58.8% vs. 34.8, p<0.001). In both sexes, the greater the number of MS components presents, the greater the serum ferritin levels. After adjustment for age, alcohol intake, and menopausal status, the OR for metabolic syndrome, comparing the fourth quartile of ferritin with the first quartile, was 2.21 (95% confidence interval ; CI=1.26-3.87; p-trend=0.024) in men and 2.10 (95% CI=1.40-3.17; p-trend=0.001) in women. However, after further adjustment for BMI, hs-CRP, and ALT, the ORs were statistically attenuated in both sexes. Conclusions : Moderately elevated serum ferritin levels were not independently associated with the prevalence of the MS after adjusting for other risk factors. Further studies are needed to obtain evidence concerning the association between serum ferritin levels and the MS.
Abstract
the relationship between serum ferritin and the metabolic syndrome (MS). Methods : We conducted a cross-sectional study of 1,444 adults over age 40 and under age 70 that lived in a rural area and participated in a survey conducted as part of the Korean Rural Genomic Cohort Study (KRGCS). The MS was defined as the presence of at least three of the followings: elevated blood pressure, low high density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, or abdominal obesity. After adjustment for age, alcohol intake, menopausal status, body mass index (BMI), high sensitivity C-reactive protein (hs-CRP), and alanine aminotransferase (ALT), odds ratios (ORs) for the prevalence of the MS by sex were calculated for quartiles of serum ferritin using logistic regression analysis. Results : The MS was more common in those persons with the highest levels of serum ferritin, compared to persons with the lowest levels, in men (37.1% vs. 22.4%, p=0.006) and women (58.8% vs. 34.8, p<0.001). In both sexes, the greater the number of MS components presents, the greater the serum ferritin levels. After adjustment for age, alcohol intake, and menopausal status, the OR for metabolic syndrome, comparing the fourth quartile of ferritin with the first quartile, was 2.21 (95% confidence interval ; CI=1.26-3.87; p-trend=0.024) in men and 2.10 (95% CI=1.40-3.17; p-trend=0.001) in women. However, after further adjustment for BMI, hs-CRP, and ALT, the ORs were statistically attenuated in both sexes. Conclusions : Moderately elevated serum ferritin levels were not independently associated with the prevalence of the MS after adjusting for other risk factors. Further studies are needed to obtain evidence concerning the association between serum ferritin levels and the MS.
참고문헌 (25)
- Heeney, M.M., "Iron homeostasis and inherited iron overload disorders: An overview", Hematol Oncol Clin North Am, 18(6), pp.1379~1403 (2004)
- Tuomainen, T.P., "Body iron stores are associated with serum insulin and blood glucose concentrations", Diabetes care, 20(3), pp.426~428 (1997)
- Jehn, M., "Serum ferritin and risk of the metabolic syndrome in US adults", Diabetes Care, 27(10), pp.2422~2428 (2004)
- Salonen, J.T., "Relation between iron stores and non-insulin dependent diabetes in men: Case-control study", BMJ, 317(7160), pp.724~ (1998)
- Jiang, R., "Body iron stores in relation to risk of type 2 diabetes in apparently healthy women", J.A.M.A, 291(6), pp.711~717 (2004)
- Jehn, M.L., "A prospective study of plasma ferritin level and incident diabetes: The atherosclerosis risk in communities (ARIC) study", Am J Epidemiol, 165(9), pp.1047~1054 (2007)
- Piperno, A., "Increased serum ferritin is common in men with essential hypertension", J Hypertens, 20(8), pp.1513~1518 (2002)
- Williams MJ, "Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women", Atherosclerosis, 165(1), pp.179~184 (2002)
- Gillum, R.F., "Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men: The Third National Health and Nutrition Examination Survey", Int J Obes Relat Metab Disord, 25(5), pp.639~645 (2001)
- Cho, Y.S., "Association of serum ferritin and abdominal obesity and insulin resistance", J Korean Soc Study Obes, 14(2), pp.76~81 (2005)
- Fernandez-Real, J.M., "Serum ferritin as a component of the insulin resistance syndrome", Diabetes Care, 21(1), pp.62~68 (1998)
- Sheu, W.H.H., "A relationship between serum ferritin and insulin resistance syndrome is present in non-diabetic women but non-diabetic men", Clin Endocrinol, 58(3), pp.380~385 (2003)
- Gonzalez, A.S., "Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin", Eur J Clin Nutr, 60(6), pp.802~809 (2006)
- Vari, I.S., "Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)", Diabetes Care, 30(7), pp.1795~1801 (2007)
- Ferrannini, E., "Insulin resistance, iron and liver", Lancet, 355(9222), pp.2181~2182 (2000)
- Niederau, C., "Hyperinsulinemia in non-cirrhotic hemochromatosis: Impaired hepatic insulin degradation?", Diabetologia, 26(6), pp.441~444 (1984)
- Wolff, S.P., "Diabetes mellitus and free radicals : free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications", Br Med Bull, 49(3), pp.642~652 (1993)
- Choi, K.M., "Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women", Metabolism, 54(11), pp.1510~1514 (2005)
- Halle, M., "Relationship of serum ferritin concentrations with metabolic cardiovascular risk factors in men without evidence for coronary artery disease", Atherosclerosis, 128, pp.(2) (1997), 235~240
- Andrews, N.C., "Disorders of iron metabolism", N Engl J Med, 341(26), pp.1986~1995 (1999)
- Zacharski, L., "Association of age, sex and race with body iron stores in adults: analysis of NHANES III data", Am Heart J, 140(1), pp.98~104 (2000)
- Witte, D.L., "Practice guideline development task force of the college of american pathologist. Hereditary hemochromatosis", Clin Chim Acta, 245(2), pp.139~200 (1996)
- Ridker, P.M., "Creactive protein, the metabolic syndrome, and risk of incident cardiovascular events. An 8- year follow-up of 14719 initially healthy Am women", Circulation, 107(3), pp.391~397 (2003)
- Oberly, L.W., "Free radicals and diabetes", Free Radic Biol Med, 5(2), pp.113~124 (1988)
- Hsiao, T.J., "Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in apparently healthy obese patients", Int J Obes Relat Metab Disord, 28(1), pp.167~172 (2004)