한국인에서 높은 혈청 페리틴 수치와 당뇨와의 상관관계
Serum Ferritin Levels Are Associated with the Higher Risk of Diabetes Mellitus in Men and Post-menopausal Women, Based on the 2010-2012 KNHANES
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연구배경: 한국 성인을 대상으로 당뇨와 혈청 페리틴의 상관관계를 알아보고자 하였다. 방법: 국민건강영양조사 제5기(2010-2012년) 자료에서 19 세 이상의 한국 성인 9,576명(남자 4,264명, 폐경 전 여성2,394명, 폐경 후 여성 2,918명)을 대상으로 연구를 시행하였다. 당뇨는 공복 혈당 ≥126 mg/dL이거나 당화혈색소 ≥ 6.5%, 또는 경구혈당강하제를 복용하거나 인슐린 치료를받고 있는 경우로 정의하였다. 결과: 당뇨 유병률은 남성, 폐경 전 여성, 폐경 후 여성에서 각각 12.0%, 3.6%, 17.3%로 나타났다. 혈청 페리틴 사분위가 증가할수록 당뇨 유병률은 증가하는 것으로 나타났다. 제1사분위에서 제4사분위로 갈수록 유병률이 남자에서는 10.3%, 10.2%, 12.7%, 14.8%; 폐경 전 여성에서는 2.0%, 2.8%, 2.8%, 6.4%; 폐경 후 여성에서는 13.9%, 14.4%, 18.1%, 22.9%로 나타났다. 제1사분위에 비해 제4사분위 교차비(95% 신뢰구간)가 연령 등을 보정한 후, 남성에서는1.67 (1.20-2.32), 폐경 전 여성에서는 2.06 (0.91-4.66), 폐경후 여성에서는 1.60 (1.09-2.35)로 나타났다. 결론: 한국 남성 및 폐경 후 여성에서 혈청 페리틴 수치는 당뇨 증가와 연관이 있었다.
Abstract
Background:The aim of this study was to investigate the relationship between serum ferritin and diabetes mellitus (DM) in the Korean population. Methods:This cross-sectional study included 9,576 subjects (4,264 men, 2,394 pre-menopausal women, and 2,918 post-menopausal women) older than 19 years using data from the 2010-2012 Korean National Health and Nutrition Examination Survey. DM was defined as fasting plasma glucose ≥126 mg/dL, glycosylated hemoglobin ≥6.5%, or use of any glucose-lower medication including insulin therapy. Results:The overall prevalence of DM was 12.0, 3.6, and 17.3% in men, pre-menopausal women, and post-menopausal women, respectively. DM prevalence was greater with ferritin levels from Q1 to Q4: 10.3, 10.2, 12.7, and 14.8% in men; 2.0, 2.8, 2.8, and 6.4% in pre-menopausal women; and 13.9, 14.4, 18.1, and 22.9% in post-menopausal women, respectively. Compared with participants in Q1, the odds ratios (95% confidence intervals) for DM among participants in Q4 were 1.67 (1.20-2.32) in men, 2.06 (0.91-4.66) in pre-menopausal women, and 1.60 (1.09-2.35) in post-menopausal women after adjusting for age and other covariates. Conclusion:Serum ferritin concentration was positively associated with a higher risk of DM in adult men and post-menopausal women.
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