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건강증진센터를 내원한 폐경 및 폐경주변기 여성에서 혈청 Ferritin과 대사증후군

Serum Ferritin and Metabolic Syndrome in Perimenopausal and Postmenopausal Women

조수현
대한폐경학회 (Korean Society Of Menopause)|2011.12|대한폐경학회지 (Journal of Menopausal Medicine)|제17권 제3호|pp. 166-173|DOI http://dx.doi.org/

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대사증후군PostmenopauseWomen여성Metabolic SyndromeCardiovascular diseasesFerritin폐경기동맥경화Atherosclerosis심혈관 질환Ferritins

초록

연구목적: 폐경 및 폐경주변기 여성에서 혈청 ferritin과 대사증후군에 대하여 알아보았다. 연구재료 및 방법: 2007년 1월부터 4월까지 종합병원 건강증진센터를 방문한 2,091명을 대상으로 대사증후군 (metabolic syndrome, MetS)과 대사증후군이 아닌 군 (non-metabolic syndrome group, Non-MetS) 간 비교하였다. 결과: 평균 혈청 ferritin 수치는 MetS 65.16 ± 33.69 ng/mL, Non-MetS 57.82 ± 32.51 ng/mL이었다 (P = 0.000). MetS에서 혈청 ferritin과의 상관관계는 헤모글로빈, 인슐린, homeostasis model assessment of insulin resistance (HOMA-IR), 중성지방, aspartate transaminase (SGOT), alanine transaminase (SGPT), 혈청 요산, high-sensitivity C-reactive protein (hs-CRP)와 약한 양의 상관관계를 보였고 고밀도 지단백, 저밀도 지단백과는 약한 음의 상관관계를 보였으며 (P ＜ 0.05) 다단계 다중회귀분석상 hs-CRP, 고밀도 지단백, SGOT, HOMA-IR, 헤모글로빈 수치가 유의하였다 (R2 = 0.106; P ＜ 0.05). 결론: 혈청 ferritin 수치가 MetS에서 Non-MetS보다 유의하게 높았고, hs-CRP, SGOT, HOMA-IR, 헤모글로빈 수치가 증가할수록 고밀도 지단백 수치는 낮아질수록 증가하였다.

Abstract

Objectives: The purpose of this study was to examine the relationship between serum ferritin and metabolic syndrome in peri- and postmenopausal women. Methods: The study subjects consisted of 2,091 peri- and postmenopausal women who visited the hospital for a health check-up in 2007. They were divided into the metabolic syndrome group (MetS) and the non-metabolic syndrome group (Non-MetS). Results: Mean serum ferritin values were 65.16 ± 33.69 ng/mL in MetS and 57.82 ± 32.51 ng/mL in Non-MetS (P = 0.000). In MetS, serum ferritin had a positive correlation with hemoglobin (Hb), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, aspartate transaminase (SGOT), alanine transaminase (SGPT), uric acid, and high-sensitivity C-reactive protein (hs-CRP) but a negative correlation with high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol (P ＜ 0.05). From multiple linear models, hs-CRP, HDL-cholesterol, SGOT, HOMA-IR, and hemoglobin level were found to be the best predictors of serum ferritin in MetS (R2 = 0.106; P ＜ 0.05). Conclusion: The serum ferritin level in MetS was higher than in Non-MetS in postmenopausal women. In MetS, with increasing hs-CRP, SGOT, HOMA-IR, and hemoglobin levels and decreasing HDL-cholesterol levels, the serum ferritin level seems to increase. (J Korean Soc Menopause 2011;17:166-173)

참고문헌 (39)

  1. Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults, "Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)", JAMA, 285, pp.2486~2497 (2001)
  2. Lakka HM, "The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men", JAMA, 288, pp.2709~2716 (2002)
  3. Hanson RL, "Components of the "metabolic syndrome" and incidence of type 2 diabetes", Diabetes, 51, pp.3120~3127 (2002)
  4. Cook JD, "Serum ferritin: a possible model for the assessment of nutrient stores", Am J Clin Nutr, 35, pp.1180~1185 (1982)
  5. Gillum RF, "Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men--the Third National Health and Nutrition Examination Survey", Int J Obes Relat Metab Disord, 25, pp.639~645 (2001)
  6. Freixenet N, "Serum soluble transferrin receptor concentrations are increased in central obesity. Results from a screening programme for hereditary hemochromatosis in men with hyperferritinemia", Clin Chim Acta, 400, pp.111~116 (2009)
  7. Piperno A, "Increased serum ferritin is common in men with essential hypertension", J Hypertens, 20, pp.1513~1518 (2002)
  8. Halle M, "Relationship of serum ferritin concentrations with metabolic cardiovascular risk factors in men without evidence for coronary artery disease", Atherosclerosis, 128, pp.235~240 (1997)
  9. Williams MJ, "Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women", Atherosclerosis, 165, pp.179~184 (2002)
  10. Tuomainen TP, "Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men", Diabetes Care, 20, pp.426~428 (1997)
  11. Walker BL, "Iron metabolism in mammalian cells", Int Rev Cytol, 211, pp.241~278 (2001)
  12. Richardson DR, "The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells", Biochim Biophys Acta, 1331, pp.1~40 (1997)
  13. Ferrannini E, "Insulin resistance, iron, and the liver", Lancet, 355, pp.2181~2182 (2000)
  14. Niederau C, "Hyperinsulinaemia in non-cirrhotic haemochromatosis: impaired hepatic insulin degradation", Diabetologia, 26, pp.441~444 (1984)
  15. Salonen JT, "Relation between iron stores and non-insulin dependent diabetes in men: case-control study", BMJ, 317, pp.727~ (1998)
  16. Wolff SP, "Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications", Br Med Bull, 49, pp.642~652 (1993)
  17. Gonzalez AS, "Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin", Eur J Clin Nutr, 60, pp.802~809 (2006)
  18. Mainous AG 3rd, "Association of ferritin and lipids with C-reactive protein", Am J Cardiol, 93, pp.559~562 (2004)
  19. Yuan XM, "Effects of iron- and hemoglobin-loaded human monocyte-derived macrophages on oxidation and uptake of LDL", Arterioscler Thromb Vasc Biol, 15, pp.1345~1351 (1995)
  20. Pratico D, "Iron-dependent human platelet activation and hydroxyl radical formation: involvement of protein kinase C", Circulation, 99, pp.3118~3124 (1999)
  21. Jehn M, "Serum ferritin and risk of the metabolic syndrome in U.S. adults", Diabetes Care, 27, pp.2422~2428 (2004)
  22. Sun L, "Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly chinese", J Clin Endocrinol Metab, 93, pp.4690~4696 (2008)
  23. Jiang R, "Body iron stores in relation to risk of type 2 diabetes in apparently healthy women", JAMA, 291, pp.711~717 (2004)
  24. Cho YS, "Association of serum ferritin and abdominal obesity and insulin resistance", Korean J Obes, 14, pp.76~81 (2005)
  25. 이병국, "Association of serum ferritin with metabolic syndrome and diabetes mellitus in the South Korean general population according to the Korean National Health and Nutrition Examination Survey 2008", METABOLISM-CLINICAL AND EXPERIMENTAL, 60(10), pp.1416~1424, W B SAUNDERS CO-ELSEVIER INC
  26. Kim CH, "Association of elevated serum ferritin concentration with insulin resistance and impaired glucose metabolism in Korean men and women", Metabolism, 60, pp.414~420 (2011)
  27. Choi KM, "Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women", Metabolism, 54, pp.1510~1514 (2005)
  28. 류소연, "농촌 지역 주민의 혈청 ferritin 수준과 대사증후군과의 관련성", 예방의학회지, 41(2), pp.115~120 (2008), 대한예방의학회
  29. 김희경, "건강검진 수검자에서 혈청 Ferritin과 대사증후군의 관련성", 대한비만학회지, 19(2), pp.48~55 (2010), 대한비만학회
  30. Cho GJ, "Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women", Menopause, 18, pp.1120~1124 (2011)
  31. Ryoo JH, "The relationship between serum ferritin and metabolic syndrome in healthy Korean men", Diabetes Metab Res Rev, 27, pp.597~603 (2011)
  32. Matthews DR, "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)
  33. Lee S, "Cut-off points of waist circumference for defining abdominal obesity in the Korean population", Korean J Obes, 15, pp.1~9 (2006)
  34. Sullivan JL, "Iron and the sex difference in heart disease risk", Lancet, 1, pp.1293~1294 (1981)
  35. .Fischer JG, "Moderate iron overload enhances lipid peroxidation in livers of rats, but does not affect NF-kappaB activation induced by the peroxisome proliferator, Wy-14,643", J Nutr, 132, pp.2525~2531 (2002)
  36. Libby P, "Inflammation and atherosclerosis", Circulation, 105, pp.1135~1143 (2002)
  37. Fernandez-Real JM, "Serum ferritin as a component of the insulin resistance syndrome", Diabetes Care, 21, pp.62~68 (1998)
  38. 한아름, "혈청 페리틴과 심혈관계 위험인자의 관련성", Korean Journal of Family Medicine, 27(5), pp.357~363 (2006), 대한가정의학회
  39. 오은실, "건강증진센터를 내원한 성인에서 혈청 페리틴과 고감도 C-반응 단백과의 관련성", Korean Journal of Family Medicine, 29(12), pp.908~914 (2008), 대한가정의학회

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