The Association Between Serum Albumin Levels and Metabolic Syndrome in a Rural Population of Korea
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Objectives: A positive association between serum albumin levels and metabolic syndrome has been reported in observation studies, but it has not been established in the Korean population. The purpose of this study was to evaluate the association between serum albumin levels and the presence of metabolic syndrome among a sample of apparently healthy Korean adults. Methods: This cross-sectional study analyzed data of 3189 community-dwelling people (1189 men and 2000 women) who were aged 40 to 87 years and were living in a rural area in Korea. Serum albumin levels were classified into quartile groups for each sex. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines with an adjusted waist circumference cut-off value (≥90 cm for men and ≥85 cm for women). An independent association between serum albumin levels and metabolic syndrome was assessed by multiple logistic regression analysis. Results: Higher serum albumin levels were associated with increased prevalence of metabolic syndrome. The odds ratio (95% confidence interval) of the prevalence of metabolic syndrome for the highest versus the lowest serum albumin quartiles was 2.81 (1.91 to 4.14) in men and 1.96 (1.52 to 2.52) in women, after adjusting for age, smoking status, alcohol consumption, and physical activity. When each metabolic abnormality was analyzed separately, higher serum albumin levels were significantly associated with hypertriglyceridemia and hyperglycemia in both sexes, and with abdominal obesity in men. Conclusions: These results suggest that higher serum albumin levels are positively associated with an increased risk of metabolic syndrome in Korean adults.
Abstract
Objectives: A positive association between serum albumin levels and metabolic syndrome has been reported in observation studies, but it has not been established in the Korean population. The purpose of this study was to evaluate the association between serum albumin levels and the presence of metabolic syndrome among a sample of apparently healthy Korean adults. Methods: This cross-sectional study analyzed data of 3189 community-dwelling people (1189 men and 2000 women) who were aged 40 to 87 years and were living in a rural area in Korea. Serum albumin levels were classified into quartile groups for each sex. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines with an adjusted waist circumference cut-off value (≥90 cm for men and ≥85 cm for women). An independent association between serum albumin levels and metabolic syndrome was assessed by multiple logistic regression analysis. Results: Higher serum albumin levels were associated with increased prevalence of metabolic syndrome. The odds ratio (95% confidence interval) of the prevalence of metabolic syndrome for the highest versus the lowest serum albumin quartiles was 2.81 (1.91 to 4.14) in men and 1.96 (1.52 to 2.52) in women, after adjusting for age, smoking status, alcohol consumption, and physical activity. When each metabolic abnormality was analyzed separately, higher serum albumin levels were significantly associated with hypertriglyceridemia and hyperglycemia in both sexes, and with abdominal obesity in men. Conclusions: These results suggest that higher serum albumin levels are positively associated with an increased risk of metabolic syndrome in Korean adults.
참고문헌 (32)
- Harris D, "Malnutrition screening in the elderly population", J R Soc Med, 98(9), pp.411~414 (2005)
- Roche M, "The antioxidant properties of serum albumin", FEBS Lett, 582(13), pp.1783~1787 (2008)
- Arroyo V, "Human serum albumin: not just a plasma volume expander", Hepatology, 50(2), pp.355~357 (2009)
- Phillips A, "Association between serum albumin and mortality from cardiovascular disease, cancer, and other causes", Lancet, 2(8677), pp.1434~1436 (1989)
- Gillum RF, "Serum albumin, coronary heart disease, and death", Am Heart J, 123(2), pp.507~513 (1992)
- Djousse L, "Serum albumin and risk of myocardial infarction and allcause mortality in the Framingham Offspring Study", Circulation, 106(23), pp.2919~2924 (2002)
- Djousse L, "NHLBI Family Heart Study. Relation between serum albumin and carotid atherosclerosis: the NHLBI Family Heart Study", Stroke, 34(1), pp.53~57 (2003)
- Folsom AR, "Low serum albumin. Association with diabetes mellitus and other cardiovascular risk factors but not with prevalent cardiovascular disease or carotid artery intimamedia thickness. The Atherosclerosis Risk in Communities (ARIC) Study Investigators", Ann Epidemiol, 5(3), pp.186~191 (1995)
- Nelson JJ, "Serum albumin level as a predictor of incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study", Am J Epidemiol, 151(5), pp.468~477 (2000)
- Danesh J, "Risk factors for coronary heart disease and acute-phase proteins. A population-based study", Eur Heart J, 20(13), pp.954~959 (1999)
- Ishizaka N, "Association between serum albumin, carotid atherosclerosis, and metabolic syndrome in Japanese individuals", Atherosclerosis, 193(2), pp.373~379 (2007)
- Kadono M, "Serum albumin levels predict vascular dysfunction with paradoxical pathogenesis in healthy individuals", Atherosclerosis, 209(1), pp.266~270 (2010)
- Ford ES, "Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence", Diabetes Care, 28(7), pp.1769~1778 (2005)
- Galassi A, "Metabolic syndrome and risk of cardiovascular disease: a meta-analysis", Am J Med, 119(10), pp.812~819 (2006)
- Friedewald WT, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge", Clin Chem, 18(6), pp.499~502 (1972)
- Matthews DR, "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28(7), pp.412~419 (1985)
- Grundy SM, "Diagnosis and management of the metabolic syndrome: an American Heart Association", National Heart, Lung, and Blood Institute Scientific Statement, 2005, pp.112(17), 2735~2752
- Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults", DIABETES RES CLIN PRACT, 75(1), pp.72~80 (2007), ELSEVIER IRELAND LTD
- Lemieux S, "Sex differences in the relation of visceral adipose tissue accumulation to total body fatness", Am J Clin Nutr, 58(4), pp.463~467 (1993)
- Pouliot MC, "Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women", Am J Cardiol, 73(7), pp.460~468 (1994)
- Kuk JL, "Waist circumference and abdominal adipose tissue distribution: influence of age and sex", Am J Clin Nutr, 81(6), pp.1330~1334 (2005)
- Lovejoy JC, "Sex differences in obesity and the regulation of energy homeostasis", Obes Rev, 10(2), pp.154~167 (2009)
- Jefferson DM, "Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes", Hepatology, 5(1), pp.14~20 (1985)
- Baker ME, "Albumin, steroid hormones and the origin of vertebrates", J Endocrinol, 175(1), pp.121~127 (2002)
- Kaysen GA, "Determinants of albumin concentration in hemodialysis patients", Am J Kidney Dis, 29(5), pp.658~668 (1997)
- Yeun JY, "Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis patients", Am J Kidney Dis, 30(6), pp.923~927 (1997)
- MacLennan WJ, "Protein intake and serum albumin levels in the elderly", Gerontology, 23(5), pp.360~367 (1977)
- Kelman L, "Effects of dietary protein restriction on albumin synthesis, albumin catabolism, and the plasma aminogram", Am J Clin Nutr, 25(11), pp.1174~1178 (1972)
- Thalacker-Mercer AE, "Dietary protein intake affects albumin fractional synthesis rate in younger and older adults equally", Nutr Rev, 66(2), pp.91~95 (2008)
- Linn T, "Effect of long-term dietary protein intake on glucose metabolism in humans", Diabetologia, 43(10), pp.1257~1265 (2000)
- Wolever TM, "Low dietary fiber and high protein intakes associated with newly diagnosed diabetes in a remote aboriginal community", Am J Clin Nutr, 66(6), pp.1470~1474 (1997)
- Wang ET, "Higher protein intake is associated with diabetes risk in South Asian Indians: the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study", J Am Coll Nutr, 29(2), pp.130~135 (2010)