Enhanced compatibility and initial stability of Ti6Al4V alloy orthodontic miniscrews subjected to anodization, cyclic precalcification, and heat treatment
2
조회
0
다운로드
6
인용
0
참고문헌
키워드
초록
Objective: To evaluate the bioactivity, and the biomechanical and bone-regenerative properties of Ti6Al4V miniscrews subjected to anodization, cyclic precalcification, and heat treatment (APH treatment) and their potential clinical use. Methods: The surfaces of Ti6Al4V alloys were modified by APH treatment. Bioactivity was assessed after immersion in simulated body fluid for 3 days. The hydrophilicity and the roughness of APH-treated surfaces were compared with those of untreated (UT) and anodized and heat-treated (AH) samples. For in vivo tests, 32 miniscrews (16 UT and 16 APH) were inserted into 16 Wistar rats, one UT and one APH-treated miniscrew in either tibia. The miniscrews were extracted after 3 and 6 weeks and their osseointegration (n = 8 for each time point and group) was investigated by surface and histological analyses and removal torque measurements. Results: APH treatment formed a dense surface array of nanotubular TiO2 layer covered with a compact apatite-like film. APH-treated samples showed better bioactivity and biocompatibility compared with UT and AH samples. In vivo, APH-treated miniscrews showed higher removal torque and bone-to-implant contact than did UT miniscrews, after both 3 and 6 weeks (p < 0.05). Also, early deposition of densely mineralized bone around APH-treated miniscrews was observed, implying good bonding to the treated surface. Conclusions: APH treatment enhanced the bioactivity, and the biomechanical and bone regenerative properties of the Ti6Al4V alloy miniscrews. The enhanced initial stability afforded should be valuable in orthodontic applications.
Abstract
Objective: To evaluate the bioactivity, and the biomechanical and bone-regenerative properties of Ti6Al4V miniscrews subjected to anodization, cyclic precalcification, and heat treatment (APH treatment) and their potential clinical use. Methods: The surfaces of Ti6Al4V alloys were modified by APH treatment. Bioactivity was assessed after immersion in simulated body fluid for 3 days. The hydrophilicity and the roughness of APH-treated surfaces were compared with those of untreated (UT) and anodized and heat-treated (AH) samples. For in vivo tests, 32 miniscrews (16 UT and 16 APH) were inserted into 16 Wistar rats, one UT and one APH-treated miniscrew in either tibia. The miniscrews were extracted after 3 and 6 weeks and their osseointegration (n = 8 for each time point and group) was investigated by surface and histological analyses and removal torque measurements. Results: APH treatment formed a dense surface array of nanotubular TiO2 layer covered with a compact apatite-like film. APH-treated samples showed better bioactivity and biocompatibility compared with UT and AH samples. In vivo, APH-treated miniscrews showed higher removal torque and bone-to-implant contact than did UT miniscrews, after both 3 and 6 weeks (p < 0.05). Also, early deposition of densely mineralized bone around APH-treated miniscrews was observed, implying good bonding to the treated surface. Conclusions: APH treatment enhanced the bioactivity, and the biomechanical and bone regenerative properties of the Ti6Al4V alloy miniscrews. The enhanced initial stability afforded should be valuable in orthodontic applications.
참고문헌 (22)
- Ikeda H, "Three-dimensional analysis of peribone-implant contact of rough-surface miniscrew implants", Am J Orthod Dentofacial Orthop, 139, pp.e153~e163 (2011)
- Kim SH, "Rotational Resistance of Surface-Treated Mini-implants", ANGLE ORTHODONTIST, 79, pp.899~907 (2009), MOSBY-ELSEVIER
- Chang CS, "The effect of microrough surface treatment on miniscrews used as orthodontic anchors", Clin Oral Implants Res, 20, pp.1178~1184 (2009)
- Chaddad K, "Influence of surface characteristics on survival rates of mini-implants", Angle Orthod, 78, pp.107~113 (2008)
- Wu X, "Biomechanical and histomorphometric analyses of the osseointegration of microscrews with different surgical techniques in beagle dogs", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 106, pp.644~650 (2008)
- Suzuki EY, "Placement and removal torque values of orthodontic miniscrew implants", Am J Orthod Dentofacial Orthop, 139, pp.669~678 (2011)
- Wu TY, "Factors associated with the stability of mini-implants for orthodontic anchorage:a study of 414 samples in Taiwan", J Oral Maxillofac Surg, 67, pp.1595~1599 (2009)
- Chen Y, "Clinical and histologic analysis of the stability of microimplants with immediate orthodontic loading in dogs", Am J Orthod Dentofacial Orthop, 136, pp.260~267 (2009)
- Lee NK, "Effects of the diameter and shape of orthodontic mini-implants on microdamage to the cortical bone", Am J Orthod Dentofacial Orthop, 138, pp.8. e1~8. e8 (2010)
- Morais LS, "Titanium alloy mini-implants for orthodontic anchorage: immediate loading and metal ion release", Acta Biomater, 3, pp.331~339 (2007)
- Chen F, "Anchorage effect of osseointegrated vs nonosseointegrated palatal implants", Angle Orthod, 76, pp.660~665 (2006)
- Park IS, "Effect of Cyclic Precalcification of Nanotubular TiO2 Layer on the Bioactivity of Titanium Implant", BIOMED RESEARCH INTERNATIONAL, pp.293627~ (2013), HINDAWI PUBLISHING CORPORATION
- Nguyen TDT, "Enhanced biocompatibility of a pre-calcified nanotubular TiO2layer on Ti–6Al–7Nb alloy", Surf Coatings Technol, 236, pp.127~134 (2013)
- Eaninwene G 2nd, "Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces", Int J Nanomedicine, 3, pp.257~264 (2008)
- Peng L, "Long-term small molecule and protein elution from TiO2 nanotubes", Nano Lett, 9, pp.1932~1936 (2009)
- Webster TJ, "Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo", Biomaterials, 25, pp.4731~4739 (2004)
- Yadav S, "Microdamage of the cortical bone during mini-implant insertion with self-drilling and selftapping techniques: a randomized controlled trial", Am J Orthod Dentofacial Orthop, 141, pp.538~546 (2012)
- Chen Y, "Biomechanical and histological comparison of self-drilling and selftapping orthodontic microimplants in dogs", Am J Orthod Dentofacial Orthop, 133, pp.44~50 (2008)
- Oh SH, "Growth of nano-scale hydroxyapatite using chemically treated titanium oxide nanotubes", Biomaterials, 26, pp.4938~4943 (2005)
- Yao C, "Anodized Ti and Ti6Al4V possessing nanometer surface features enhances osteoblast adhesion", J Biomed Nanotechnol, 1, pp.68~73 (2005)
- Salata LA, "Osseointegration of oxidized and turned implants in circumferential bone defects with and without adjunctive therapies:an experimental study on BMP-2 and autogenous bone graft in the dog mandible", Int J Oral Maxillofac Surg, 36, pp.62~71 (2007)
- Liou EJ, "Do miniscrews remain stationary under orthodontic forces?", Am J Orthod Dentofacial Orthop, 126, pp.42~47 (2004)