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Epidemiologic research on lung damage caused by humidifier disinfectants

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초록

In April 2011 a tertiary hospital located in Seoul, Korea reported several cases of severe respiratory distress of unknown origin in young adults. To find the route of transmission, causative agent and patient risk factors of the outbreak, an investigation of the epidemic was initiated. A hospital based case-control study was conducted to indicate that humidifier detergent use was the cause of the outbreak. This information led the Ministry of Health and Welfare of Korea issued an order that humidifier detergents should be withdrawn from the market. Here, we describe the major events of planning, execution, and interpretation of the study, and discussions between researchers and public authorities following the decision to perform an epidemiologic study, chronologically.

Abstract

In April 2011 a tertiary hospital located in Seoul, Korea reported several cases of severe respiratory distress of unknown origin in young adults. To find the route of transmission, causative agent and patient risk factors of the outbreak, an investigation of the epidemic was initiated. A hospital based case-control study was conducted to indicate that humidifier detergent use was the cause of the outbreak. This information led the Ministry of Health and Welfare of Korea issued an order that humidifier detergents should be withdrawn from the market. Here, we describe the major events of planning, execution, and interpretation of the study, and discussions between researchers and public authorities following the decision to perform an epidemiologic study, chronologically.

참고문헌 (5)

  1. Hong SB, "A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome", Thorax, 69, pp.694~702 (2014)
  2. Kim HJ, "A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation", Thorax, 69, pp.703~708 (2014)
  3. Kim KW, "Humidifier disinfectant-associated children’s interstitial lung disease", Am J Respir Crit Care Med, 189, pp.48~56 (2014)
  4. Park JH, "Humidifier disinfectants are a cause of lung injury among adults in South Korea: a community-based case-control study", PLoS One, 11, pp.e0151849~ (2016)
  5. Yang HJ, "Inhalation toxicity of humidifier disinfectants as a risk factor of children’s interstitial lung disease in Korea: a case-control study", PLoS One, 8, pp.e64430~ (2013)

관련 논문AI추천

Evaluation report on the causal association between humidifier disinfectants and lung injury박혜숙, 신승수, 이순영, 정해관, 최보율, 하미나, 황승식한국역학회 · Epidemiology and Health2016 · 제38권 가습기 살균제 건강영향 모니터링에서 환경노출조사의 역할김소연, 김현일, 김형철, 문은찬, 박동욱, 박소영, 박주현, 박지훈, 이승희, 이예성, 장우성한국환경보건학회 · 한국환경보건학회지2020 · 제46권 제2호Evidence integration on health damage for humidifier disinfectant exposure and legal presumption of causation정규혁, 정해관, 하미나, Baek Yong-Wook, Chung Hyun Mi, Kim Younghee, Lee Jong-Hyeon, Lim Jungyun, Park Taehyun, Yu Sol한국역학회 · Epidemiology and Health2023 · 제45권 가습기 살균제 노출 및 건강피해 규모 평가 연구김솔휘, 김판기, 김형수, 백도명, 서정욱, 이경무, 이종화, 임종한, 정해관, 홍영습한국환경보건학회 · 한국환경보건학회지2019 · 제45권 제3호Risk of non-cancer respiratory diseases attributed to humidifier disinfectant exposure in Koreans: age-period-cohort and differences-in-difference analyses정해관, Ha Mina, Heo Seungyeon, Jeong Kyoung Sook, Kim Jaiyong, Kim Suejin, Kim Younghee, Lim Jungyun, Shin Sunkyoung, Yu Sol한국역학회 · Epidemiology and Health2025 · 제47권 가습기살균제 노출로 인한 건강피해 신고자의 지역별 편차에 대한 고찰박진현, 양원호, 오재현, 윤정교, 이슬아, 조은경, 주민재, 최윤형한국환경보건학회 · 한국환경보건학회지2021 · 제47권 제4호

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