Epidemiologic research on lung damage caused by humidifier disinfectants
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초록
In April 2011 a tertiary hospital located in Seoul, Korea reported several cases of severe respiratory distress of unknown origin in young adults. To find the route of transmission, causative agent and patient risk factors of the outbreak, an investigation of the epidemic was initiated. A hospital based case-control study was conducted to indicate that humidifier detergent use was the cause of the outbreak. This information led the Ministry of Health and Welfare of Korea issued an order that humidifier detergents should be withdrawn from the market. Here, we describe the major events of planning, execution, and interpretation of the study, and discussions between researchers and public authorities following the decision to perform an epidemiologic study, chronologically.
Abstract
In April 2011 a tertiary hospital located in Seoul, Korea reported several cases of severe respiratory distress of unknown origin in young adults. To find the route of transmission, causative agent and patient risk factors of the outbreak, an investigation of the epidemic was initiated. A hospital based case-control study was conducted to indicate that humidifier detergent use was the cause of the outbreak. This information led the Ministry of Health and Welfare of Korea issued an order that humidifier detergents should be withdrawn from the market. Here, we describe the major events of planning, execution, and interpretation of the study, and discussions between researchers and public authorities following the decision to perform an epidemiologic study, chronologically.
참고문헌 (5)
- Hong SB, "A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome", Thorax, 69, pp.694~702 (2014)
- Kim HJ, "A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation", Thorax, 69, pp.703~708 (2014)
- Kim KW, "Humidifier disinfectant-associated children’s interstitial lung disease", Am J Respir Crit Care Med, 189, pp.48~56 (2014)
- Park JH, "Humidifier disinfectants are a cause of lung injury among adults in South Korea: a community-based case-control study", PLoS One, 11, pp.e0151849~ (2016)
- Yang HJ, "Inhalation toxicity of humidifier disinfectants as a risk factor of children’s interstitial lung disease in Korea: a case-control study", PLoS One, 8, pp.e64430~ (2013)
