Antiproliferative Effects of Curcumin Analogues
1
조회
0
다운로드
0
인용
0
참고문헌
초록
Curcumin and its analogues(tetrahydrocurcumin THC, demethoxycurcumin;BDMC and dimethoxy- curcumin DiMC) were compared for their ability to inhibit the growth of human leukemia HL-60 cells. The growth of HL-60 cells was inhibited by curcumin, DeMC and DiMC, but not by THC lacking α,β- unsaturated carbonyl groups thus suggesting that α,β-unsaturated carbonyl groups are crucial for antiproliferative activity. The order of antiproliferative activity was DiMC, curcumin and BDMC indicating that the number of methoxy groups on the aromatic rings of the active compounds plays an important role in enhancing anti-proliferating activity. In comparison with cellular uptake of the active compounds, uptake capacity was found to be highest with DiMC, followed by curcumin and BDMC. Therefore, it is most likely that the differential antiproliferative activities of DiMC, curcumin and BDMC are associated with their capacities of cellular uptake resulting in building up of enough concentration inside the cells.
Abstract
Curcumin and its analogues(tetrahydrocurcumin THC, demethoxycurcumin;BDMC and dimethoxy- curcumin DiMC) were compared for their ability to inhibit the growth of human leukemia HL-60 cells. The growth of HL-60 cells was inhibited by curcumin, DeMC and DiMC, but not by THC lacking α,β- unsaturated carbonyl groups thus suggesting that α,β-unsaturated carbonyl groups are crucial for antiproliferative activity. The order of antiproliferative activity was DiMC, curcumin and BDMC indicating that the number of methoxy groups on the aromatic rings of the active compounds plays an important role in enhancing anti-proliferating activity. In comparison with cellular uptake of the active compounds, uptake capacity was found to be highest with DiMC, followed by curcumin and BDMC. Therefore, it is most likely that the differential antiproliferative activities of DiMC, curcumin and BDMC are associated with their capacities of cellular uptake resulting in building up of enough concentration inside the cells.
참고문헌 (13)
- Cooper R, "Medicinal benefits of green tea:part II. review of anticancer properties", 11(4), pp.639~652 (2005)
- Thangapazham RL, "Multiple molecular targets in cancer chemoprevention by curcumin", 8(3), pp.E443~E449 (2006)
- Rahman I, "Regulation of inflammation and redox signaling by dietary polyphenols", 71(11), pp.1439~1452 (2006)
- Srivastava RK, "Bax and Bak genes are essential for maximum apoptotic response by curcumin a polyphenolic compound and cancer chemopreventive agent derived from turmeric", 28(6), pp.1277~1286 (2007)
- Jeong GS, "Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression ortho-methoxy groups are essential to enhance heme oxygenase activity and protection", 38(4), pp.393~400 (2006)
- Pae HO, "Curcumin induces pro-apoptotic endoplasmic reticulum stress in human leukemia HL-60 cells", 353(4), pp.1040~1045 (2007)
- Dimas K, "Metabolism and anticancer activity of the curcumin analogue", 13(4), pp.1269~1277 (2007)
- Chen WF, "Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups", 40(3), pp.526~535 (2006)
- Pan MH, "Biotrans- formation of curcumin through reduction and glucuronidation in mice", 27(4), pp.486~494 (1999)
- Zhao G, "The synthesis of alpha beta-unsaturated carbonyl derivatives with the ability to inhibit both glutathione S- transferase P1-1 activity and the proli- feration of leukemia cells", 16(7), pp.2701~2707 (2007)
- Honn KV, "Requirement of a reactive alpha beta-unsaturated carbonyl for inhibition of tumor growth and induc- tion of differentiation by", pp.34~40 (1985)
- Murakami A, "a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, pro-inflammatory protein production, and cancer cell pro- liferation accompanied by apoptosis:the alpha, beta-unsaturated carbonyl group is a prerequisite", 23(5), pp.795~802 (2002)
- Na HK, "Peroxisome proliferator- activated receptor gamma(PPARgamma) ligands as bifunctional regulators of cell proliferation", 66(8), pp.1381~1391 (2003)