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최근 보건의료분야에서 활발하게 연구되고 있는“Epigenetics”란 무엇인가? ―기본개념 및 기전을 중심으로―

What is Epigenetics? ―Focusing on Basic Concepts and Mechanisms―

고성규|신헌태|이선동|김명동|박성균
대한예방한의학회 (Society of Preventive Korean Medicine)|2010.08|대한예방한의학회지 (Society of Preventive Korean Medicine)|제14권 제2호|pp. 1-12

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참고문헌

키워드

environmentgeneepigeneticsgene expression and modificationDNA methylation
주제분류한의학

초록

The individual differences in disease development and susceptibility have been researched primarily on the subject of genes,environment or the interaction between genes and the environment respectively. However, there have been limitations in explaining complex diseases, and the differences in health and diseases in monozygotic and dizygotic twins. Fortunately, thanks to active research on the relationship between genes and the environment, and epigenetics, there has been much progress in the understanding of body’s reactions and changes. Epigenetics is referred to as a study of gene expression through the interactions of DNA methylation, chromatin’s histone and the change of structure in tail, RNA editing without any change in DNA sequence. In this paper, we introduce the basic concepts and mechanisms of epigenetics. The result of the epigenetics is heritable; can regulate gene expressions; is reversible; and has many variable forms depending on cell types. The influences of epigenetics occur throughout life, but it is mainly determined in utero during early pregnancies. Diseases occur or the risk rises if these influences continue after birth until adult life when problems occur in excess/lack of nutrition, environmental plasticity, or already inputted data. Therefore, there is a need for change and innovation, especially in interest and investment in health education for young women near pregnancies and correct treatment of epigenetic-related diseases.

Abstract

The individual differences in disease development and susceptibility have been researched primarily on the subject of genes,environment or the interaction between genes and the environment respectively. However, there have been limitations in explaining complex diseases, and the differences in health and diseases in monozygotic and dizygotic twins. Fortunately, thanks to active research on the relationship between genes and the environment, and epigenetics, there has been much progress in the understanding of body’s reactions and changes. Epigenetics is referred to as a study of gene expression through the interactions of DNA methylation, chromatin’s histone and the change of structure in tail, RNA editing without any change in DNA sequence. In this paper, we introduce the basic concepts and mechanisms of epigenetics. The result of the epigenetics is heritable; can regulate gene expressions; is reversible; and has many variable forms depending on cell types. The influences of epigenetics occur throughout life, but it is mainly determined in utero during early pregnancies. Diseases occur or the risk rises if these influences continue after birth until adult life when problems occur in excess/lack of nutrition, environmental plasticity, or already inputted data. Therefore, there is a need for change and innovation, especially in interest and investment in health education for young women near pregnancies and correct treatment of epigenetic-related diseases.

참고문헌 (66)

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