태아 프로그래밍과 성인기 질환
Fetal Programming and Adult Disease
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Chronic diseases such as cardiovascular disease, type 2 diabetes, and hypertension are leading causes of death and disability worldwide. Evidence from epidemiological and experimental studies suggests that adverse exposure in uterus, particularly with regard to nutrition, increases the risk of chronic disease in adults. Nutritional programming is the process through which variation in the quality or quantity of nutrients consumed during pregnancy exerts permanent effects upon the developing fetus. Research on programming in relation to disease processes has been facilitated by the development of animal models that utilize restriction or over-feeding. Such studies have introduced the concept of developmental origins of health and disease (DOHaD). The underlying mechanisms of DOHaD remain an area of research interest and intense investigation. Although great strides have been made in identifying the putative concepts and mechanisms relating specific exposure in early life to the risk of developing chronic diseases in adult, many aspects of these associations remain unclear. This paper discusses the potential mechanisms behind the DOHaD as they relate to maternal nutrition and implications for future research and clinical practice.
Abstract
Chronic diseases such as cardiovascular disease, type 2 diabetes, and hypertension are leading causes of death and disability worldwide. Evidence from epidemiological and experimental studies suggests that adverse exposure in uterus, particularly with regard to nutrition, increases the risk of chronic disease in adults. Nutritional programming is the process through which variation in the quality or quantity of nutrients consumed during pregnancy exerts permanent effects upon the developing fetus. Research on programming in relation to disease processes has been facilitated by the development of animal models that utilize restriction or over-feeding. Such studies have introduced the concept of developmental origins of health and disease (DOHaD). The underlying mechanisms of DOHaD remain an area of research interest and intense investigation. Although great strides have been made in identifying the putative concepts and mechanisms relating specific exposure in early life to the risk of developing chronic diseases in adult, many aspects of these associations remain unclear. This paper discusses the potential mechanisms behind the DOHaD as they relate to maternal nutrition and implications for future research and clinical practice.
참고문헌 (57)
- Adair LS, "Size at birth, weight in infancy and childhood, and adult blood pressure in 5 low- and middle- income-country cohorts:when does weight gain matter?", Am J Clin Nutr, 89(5), pp.1383~1392 (2009)
- Barker DJP, "Weight in infancy and death from ischaemic heart disease", Lancet, 2, pp.577~580 (1989)
- Barker DJP, "Type 2 (non-insulin dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth", Diabetologia, 36, pp.62~67 (1993)
- Barker DJ, "Trajectories of growth among children who have coronary events a adults", N Engl J Med, 353(17), pp.1802~1809 (2005)
- Bird A, "DNA methylation patterns and epigenetic memory", Gens Dev, 16, pp.6~21 (2002)
- Brenske NB, "Current thoughts on maternal nutrition and fetal programming of the metabolic syndrome", J Pregnancy, 2013, pp.368461~ (2013)
- Burton GJ, "Placental origins of chronic disease", Physiol Rev, 96(4), pp.1059~1065 (2016)
- Celsi G, "Prenatal dexamethasone cases oligonephronia, sodium retention, and higher blood pressure in the offspring", Pediatr Res, 44(3), pp.317~322 (1998)
- Ceriello A, "Is oxidative stress the pathogenic mechanism underlying insulin resistance diabetes, and cardiovascular disease? The common soil hypothesis revisited", Arterioscler Thromb Vasc Biol, 24(5), pp.816~823 (2004)
- Cheng YH, "Corticotropin-releasing hormone gene expression in primary placental cells is modulated by cyclic adenosine 3’,5’-monophosphate", J Clin Endocrinol Metab, 85(3), pp.1239~1244 (2000)
- Cianfarani S, "Intrauterine growth retardation:evidence for the activation of the insulin-like growth factor (IGF)-related growth-promoting machinery and the presence of a cation-independent IGF binding protein-3 proteolytic activity by two months of life", Pediatr Res, 44(3), pp.374~380 (1998)
- Cianfarani S, "Low birthweight and adult insulin resistance: the “catch-up growth”hypothesis", Arch Dis Child Fetal Neonatal Ed, 81(1), pp.F71~F73 (1999)
- Cottrell EC, "Foetal and placental 11βHSD2: a hub for developmental programming", Acta Physiol, 210(2), pp.288~295 (2014)
- Daenzer M, "Prenatal high protein exposure decreases energy expenditure and increases adiposity in young rats", J Nut, 132, pp.142~144 (2002)
- Dodic M, "Programming effects of short prenatal exposure to dexamethasone in sheep", Hypertension, 40, pp.729~734 (2002)
- Edwards CR, "11 beta-Hydroxysteroid dehydrogenases: key enzymes in determining tissue-specific glucocorticoid effects", Steroids, 61, pp.263~269 (1996)
- Entringer S, "Fetal programming of body composition, obesity, and metabolic function: The role of intrauterine stress and stress biology", J Nutr Metab, 2012, pp.632548~ (2012)
- Erhuma A, "Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat", Am J Physiol, 292, pp.e1702~e1714 (2007)
- Forsdahl A, "Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease?", British Journal of Preventive and Social Medicine, 31(2), pp.91~95 (1977)
- Gillman MW, "Maternal corticotropin-releasing hormone levels during pregnancy and offspring obesity", Obesity (Silver Spring), 14(9), pp.1647~1653 (2006)
- Gopalakrishnan GS, "Influence of maternal pre-pregnancy body composition and diet during early-mid pregnancy on cardiovascular function and nephron number in juvenile sheep", Br J Nutr, 94(6), pp.938~947 (2005)
- Gupta AK, "Metabolic syndrome, independent of its components, is a risk factor for stroke and death but not for coronary heart disease among hypertensive patients in the ASCOTBPLA", Diabetes Care, 33(7), pp.1647~1651 (2010)
- Hales CN, "Fetal and infant growth and impaired glucose tolerance at age 64", BMJ, 303, pp.1019~1022 (1991)
- Hales CN, "Type 2(non-insulin-dependent)diabetes mellitus: the thrifty phenotype hypothesis", Diabetologia, 35, pp.595~601 (1992)
- Harrison M, "Intergenerational programming of impaired nephrogenesis and hypertension in rats following maternal protein restriction during pregnancy", Br J Nutr, 101(7), pp.1020~1030 (2009)
- Hughson M, "Glomerular number and size in autopsy kidneys: the relationship to birth weight", Kidney Int, 63, pp.2113~2122 (2003)
- Khan IY, "Gender-linked hypertension in offspring of lard-fed pregnant rats", Hypertension, 41(1), pp.168~175 (2003)
- Khan IY, "A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring", Am J Physiol Regul Integr Comp Physiol, 288(1), pp.R127~R133 (2005)
- Langley-Evans SC, "Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat", Placenta, 17(2-3), pp.169~172 (1996)
- Langley-Evans SC, "Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat", Life Sci, 64, pp.965~974 (1999)
- Lenzen S, "Oxidative stress: the vulnerable beta-cell", Biochem Soc Trans, 36(Pt 3), pp.343~347 (2008)
- Lillycrop KA, "Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring", J Nutr, 135, pp.1382~1386 (2005)
- Lillycroip KA, "Feedng pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring", Br J Nutr, 100(2), pp.278~282 (2008)
- McCane DR, "Birth weight and noninsulin dependent diabetes: Thrifty genotype, thrifty phenotype, or surviving small baby genotype?", BMJ, 308, pp.942~945 (1994)
- Milnes MR, "Effects of incubation temperature and estrogen exposure on aromatase activity in the brain and gonads of embryonic alligators", Environ Health Perspect, 110, pp.393~396 (2002)
- Nüsken KE, "Uteroplacental insufficiency after bilateral uterine artery ligation in the rat: impact on postnatal glucose and lipid metabolism and evidence for metabolic programming of the offspring by sham operation", Endocrinology, 149, pp.1056~1063 (2008)
- Nyirenda MJ, "Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring", J Clin Invest, 101(10), pp.2741~2781 (1998)
- Ong KK, "Association between postnatal catch-up growth and obesity in childhood: prospective cohort study", BMJ, 320(7240), pp.967~971 (2000)
- Osmond C, "Early growth and death from cardiovascular disease in women", BMJ, 307(6918), pp.1519~1524 (1993)
- Ota e, "Antenatal dietary advice and supplementation to increase energy and protein intake", Cochrane Database of Systematic Review, 9, pp.CD000032~ (2012)
- 박은옥, "제 5기 국민건강영양조사로 추정한 한국 성인의 대사증후군 유병률과 관련 요인", 농촌의학.지역보건, 38(1), pp.1~13 (2013), 한국농촌의학.지역보건학회
- Plagemann A, "Hypothalamic nuclei are malformed in weaning off-spring of low protein malnourished rat dams", J Nutr, 130, pp.2582~2589 (2001)
- Roseboom TJ, "Effects of prenatal exposure to the Dutch famine on adult disease in later life:an overview", Mol Cell Endocrinol, 185, pp.93~98 (2001)
- Samuelsson AM, "Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance:a novel murine model of developmental programming", Hypertension, 51(2), pp.383~392 (2008)
- Schwitzgebel VM, "Modeling intrauterine growth retardation in rodents: Impact on pancreas development and glucose homeostasis", Mol Cell Endocrinol, 304(1-2), pp.78~83 (2009)
- Sinclair KD, "DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status", Proc Natl Acad Sci USA, 104(49), pp.19531~19536 (2007)
- Snoek A, "Effect of a lo protein diet during pregnancy on the fetal rat endocrine pancreas", Biol Neonate, 57, pp.107~118 (1990)
- Thornburg KL, "The programming of cardiovascular disease", J Dev Orig Health Dis, 6(5), pp.366~376 (2015)
- Thornburg KL, "How to build a healthy heart from scratch", Adv Exp Med Biol, 814, pp.205~216 (2014)
- Torrens C, "Folate supplementation during pregnancy inproves offspring cardiovascular dysfunction induced by protein restriction", Hypertension, 47(5), pp.982~987 (2006)
- Valdez R, "Birthweight and adult health outcomes in a biethnic population in the USA", Diabetologia, 37, pp.624~631 (1994)
- Vehaskari VM, "Prenatal programming of adult hypertension in the rat", Kidney Int, 59, pp.238~245 (2001)
- Vickers MH, "Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercalroric nutrition", Am J Physiol, 285(1), pp.R271~R273 (2003)
- Wadhwa PD, "Placental corticotropin-releasing hormone (CRH), spontaneous preterm birth, and fetal growth restriction:a prospective investigation", Am J Obstet Gynecol, 191(4), pp.1063~1069 (2004)
- Waterland RA, "Transposable elements:targets for early nutritional effects on epigenetic gene rregulation", Mol Cell Biol, 23, pp.5293~5300 (2003)
- Woodall SM, "Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring", Pediatr Res, 40(3), pp.438~443 (1996)
- Zimmet P, "A new IDF worldwide definition of the metabolic syndrome: the rationale and the results", Diabetes Voice, 50(3), pp.31~33 (2005)