Anxiety and Depression of the Patients with Hematological Malignancies during Hospitalization for Hematopoietic Stem Cell Transplantation
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Objective This study aimed to assess the anxiety and depression in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods Eighty-seven adult patients with various hematologic diseases, who were scheduled to receive autologous or allogeneic HSCT, were enrolled. The M.D. Anderson Symptom Inventory and the Hospital Anxiety Depression Scale were applied prospectively at hospital admission (D-14), on the day of transplantation (D day), and at 7 (D7) and 14 days (D14) after transplantation. Results The severity of both anxiety and depressive symptoms increased over time, with a peak at D7, and then showed a downturn at D14. Physical distresses also started with mild intensity at base line, which were continuously aggravated until D7, and then a partial recovery afterwards. Approximately, 52% of the participants had significantly high anxiety or depression before the start of HSCT. The occurrence of aggravation of pain, nausea, shortness of breath, and lack of appetite was associated with the development of anxiety during isolation period. The patients with significant baseline anxiety had higher scores on fatigue and shortness of breath items at D7 compared to those without. Conclusion Our finding suggests the importance of psychiatric approaches, including preventive measures, for the patients undergoing HSCT.
Abstract
Objective This study aimed to assess the anxiety and depression in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods Eighty-seven adult patients with various hematologic diseases, who were scheduled to receive autologous or allogeneic HSCT, were enrolled. The M.D. Anderson Symptom Inventory and the Hospital Anxiety Depression Scale were applied prospectively at hospital admission (D-14), on the day of transplantation (D day), and at 7 (D7) and 14 days (D14) after transplantation. Results The severity of both anxiety and depressive symptoms increased over time, with a peak at D7, and then showed a downturn at D14. Physical distresses also started with mild intensity at base line, which were continuously aggravated until D7, and then a partial recovery afterwards. Approximately, 52% of the participants had significantly high anxiety or depression before the start of HSCT. The occurrence of aggravation of pain, nausea, shortness of breath, and lack of appetite was associated with the development of anxiety during isolation period. The patients with significant baseline anxiety had higher scores on fatigue and shortness of breath items at D7 compared to those without. Conclusion Our finding suggests the importance of psychiatric approaches, including preventive measures, for the patients undergoing HSCT.
참고문헌 (31)
- Funke VA, "Acute and chronic Graft-versushost disease after hematopoietic stem cell transplantation", Rev Assoc Med Bras (1992), 62(Suppl 1), pp.44~50 (2016)
- Lee SJ, "Routine screening for psychosocial distress following hematopoietic stem cell transplantation", Bone Marrow Transplant, 35, pp.77~83 (2005)
- Trask PC, "Assessment of psychological distress in prospective bone marrow transplant patients", Bone Marrow Transplant, 29, pp.917~925 (2002)
- Fife BL, "Longitudinal study of adaptation to the stress of bone marrow transplantation", J Clin Oncol, 18, pp.1539~1549 (2000)
- Prieto JM, "Patient-rated emotional and physical functioning among hematologic cancer patients during hospitalization for stem-cell transplantation", Bone Marrow Transplant, 35, pp.307~314 (2005)
- Sasaki T, "Mental disturbances during isolation in bone marrow transplant patients with leukemia", Bone Marrow Transplant, 25, pp.315~318 (2000)
- Yalvac HD, "Could psychiatric assessment before hematopoietic stem cell transplantation predict the need for psychiatric consultation during transplantation period?", Transfus Apher Sci, 54, pp.85~90 (2016)
- Tecchio C, "Predictors of anxiety and depression in hematopoietic stem cell transplant patients during protective isolation", Psychooncology, 22, pp.1790~1797 (2013)
- El-Jawahri AR, "Quality of life and mood of patients and family caregivers during hospitalization for hematopoietic stem cell transplantation", Cancer, 121, pp.951~959 (2015)
- Prieto JM, "Stem cell transplantation : risk factors for psychiatric morbidity", Eur J Cancer, 42, pp.514~520 (2006)
- Loberiza FR Jr, "Association of depressive syndrome and early deaths among patients after stem-cell transplantation for malignant diseases", J Clin Oncol, 20, pp.2118~2126 (2002)
- Schulz-Kindermann F, "The role of biomedical and psychosocial factors for the prediction of pain and distress in patients undergoing high-dose therapy and BMT", PBSCT, 2002, pp.29, 341~351
- Prieto JM, "Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation", J Clin Oncol, 20, pp.1907~1917 (2002)
- Prieto JM, "Role of depression as a predictor of mortality among cancer patients after stem-cell transplantation", J Clin Oncol, 23, pp.6063~6071 (2005)
- El-Jawahri AR, "Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation", Cancer, 122, pp.806~812 (2016)
- Anderson KO, "Symptom burden in patients undergoing autologous stem-cell transplantation", Bone Marrow Transplant, 39, pp.759~766 (2007)
- Cleeland CS, "Assessing symptom distress in cancer patients: the M.D. Anderson Symptom Inventory", Cancer, 89, pp.1634~1646 (2000)
- Zigmond AS, "The hospital anxiety and depression scale", Acta Psychiatr Scand, 67, pp.361~370 (1983)
- Yun YH, "Validation study of the Korean version of the M. D. Anderson Symptom Inventory", J Pain Symptom Manage, 31, pp.345~352 (2006)
- Campagnaro E, "Symptom burden after autologous stem cell transplantation for multiple myeloma", Cancer, 112, pp.1617~1624 (2008)
- Oh SM, "A study on the standardization of the hospital anxiety and depression scale for Koreans", J Korean Neuropsychiatr Assoc, 38, pp.289~295 (1999)
- Herrmann C, "International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results", J Psychosom Res, 42, pp.17~41 (1997)
- Akaho R, "Psychological factors and survival after bone marrow transplantation in patients with leukemia", Psychiatry Clin Neurosci, 57, pp.91~96 (2003)
- Poulos AR, "Pain, mood disturbance, and quality of life in patients with multiple myeloma", Oncol Nurs Forum, 28, pp.1163~1171 (2001)
- Sela RA, "Sensory and affective dimensions of advanced cancer pain", Psychooncology, 11, pp.23~34 (2002)
- Spiegel D, "Pain and depression in patients with cancer", Cancer, 74, pp.2570~2578 (1994)
- Zaza C, "Cancer pain and psychosocial factors : a critical review of the literature", J Pain Symptom Manage, 24, pp.526~542 (2002)
- Nicolson SE, "Comorbid pain, depression, and anxiety : multifaceted pathology allows for multifaceted treatment", Harv Rev Psychiatry, 17, pp.407~420 (2009)
- Brown LF, "The association of depression and anxiety with health-related quality of life in cancer patients with depression and", or pain, 2010, pp.19, 734~741
- Stark DP, "Anxiety in cancer patients", Br J Cancer, 83, pp.1261~1267 (2000)
- 이경수, "통계 조사 방법에 대한 인지심리학적 접근: 선택지의 개수와 순서에 따른 응답의 변화", 통계연구, 13(2), pp.149~181 (2008), 통계청