Prevalence of and factors associated with anxiety and depression in Korean patients with newly diagnosed advanced gastrointestinal cancer
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Background/Aims: The purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer. Methods: One hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer who were scheduled to receive palliative chemotherapy between July 2012 and June 2014 were enrolled in this observational prospective study. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-9 (PHQ-9). Results: Thirty-seven patients (30.8%) had anxiety or depression with clinical significance according to HADS or PHQ-9. Multivariate analysis identified lower performance status (odds ratio [OR], 4.19; 95% confidence interval [CI], 1.22 to 14.35; p = 0.023), gastric cancer (OR, 5.39; 95% CI, 0.37 to 78.23; p = 0.018), and knowledge of advanced cancer (OR, 15.07; 95% CI, 1.80 to 125.90; p = 0.012) as significantly associated with anxiety or depression. Twenty-one patients with anxiety or depression visited the psycho-oncologic clinic. In these patients, PHQ-9 score (p = 0.008), global health status (p = 0.023), fatigue (p = 0.047), and appetite loss (p = 0.006) improved from baseline to 3 months after study enrollment. Conclusions: Approximately 30% of Korean patients with advanced gastrointestinal cancer had anxiety or depression. The prevalence of anxiety or depression was higher in patients with poor performance status, gastric cancer, or knowledge of advanced cancer. Psychiatric interventions may be effective in reducing depression and improving quality of life in cancer patients with anxiety or depression.
Abstract
Background/Aims: The purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer. Methods: One hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer who were scheduled to receive palliative chemotherapy between July 2012 and June 2014 were enrolled in this observational prospective study. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-9 (PHQ-9). Results: Thirty-seven patients (30.8%) had anxiety or depression with clinical significance according to HADS or PHQ-9. Multivariate analysis identified lower performance status (odds ratio [OR], 4.19; 95% confidence interval [CI], 1.22 to 14.35; p = 0.023), gastric cancer (OR, 5.39; 95% CI, 0.37 to 78.23; p = 0.018), and knowledge of advanced cancer (OR, 15.07; 95% CI, 1.80 to 125.90; p = 0.012) as significantly associated with anxiety or depression. Twenty-one patients with anxiety or depression visited the psycho-oncologic clinic. In these patients, PHQ-9 score (p = 0.008), global health status (p = 0.023), fatigue (p = 0.047), and appetite loss (p = 0.006) improved from baseline to 3 months after study enrollment. Conclusions: Approximately 30% of Korean patients with advanced gastrointestinal cancer had anxiety or depression. The prevalence of anxiety or depression was higher in patients with poor performance status, gastric cancer, or knowledge of advanced cancer. Psychiatric interventions may be effective in reducing depression and improving quality of life in cancer patients with anxiety or depression.
참고문헌 (30)
- Bultz BD, "Emotional distress: the sixth vital sign in cancer care", J Clin Oncol, 23, pp.6440~6441 (2005)[DOI]
- Skarstein J, "Anxiety and depression in cancer patients: relation between the Hospital Anxiety and Depression Scale and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire", J Psychosom Res, 49, pp.27~34 (2000)[DOI]
- Colleoni M, "Depression and degree of acceptance of adjuvant cytotoxic drugs", Lancet, 356, pp.1326~1327 (2000)[DOI]
- Steel JL, "Depression, immunity, and survival in patients with hepatobiliary carcinoma", J Clin Oncol, 25, pp.2397~2405 (2007)[DOI]
- Giese-Davis J, "Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis", J Clin Oncol, 29, pp.413~420 (2011)
- Pirl WF, "Depression and survival in metastatic non-small-cell lung cancer: effects of early palliative care", J Clin Oncol, 30, pp.1310~1315 (2012)[DOI]
- Shim EJ, "Distress and its correlates in Korean cancer patients: pilot use of the distress thermometer and the problem list", Psychooncology, 17, pp.548~555 (2008)[DOI]
- Kim SJ, "Prevalence and associated factors of psychological distress among Korean cancer patients", Gen Hosp Psychiatry, 33, pp.246~252 (2011)[DOI]
- Jeong A, "Avoidance of cancer communication, perceived social support, and anxiety and depression among patients with cancer", Psychooncology, 25, pp.1301~1307 (2016)[DOI]
- Salvo N, "Frequency of reporting and predictive factors for anxiety and depression in patients with advanced cancer", Clin Oncol (R Coll Radiol), 24, pp.139~148 (2012)[DOI]
- Linden W, "Anxiety and depression after cancer diagnosis: prevalence rates by cancer type, gender, and age", J Affect Disord, 141, pp.343~351 (2012)[DOI]
- Zabora J, "The prevalence of psychological distress by cancer site", Psychooncology, 10, pp.19~28 (2001)[DOI]
- Mitchell AJ, "Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies", Lancet Oncol, 12, pp.160~174 (2011)[DOI]
- Nordin K, "Psychological reactions in newly diagnosed gastrointestinal cancer patients", Acta Oncol, 36, pp.803~810 (1997)[DOI]
- Nordin K, "Predicting delayed anxiety and depression in patients with gastrointestinal cancer", Br J Cancer, 79, pp.525~529 (1999)[DOI]
- Tavoli A, "Anxiety and depression in patients with gastrointestinal cancer: does knowledge of cancer diagnosis matter?", BMC Gastroenterol, 7, pp.28~ (2007)[DOI]
- 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012", Cancer Research and Treatment, 47(2), pp.127~141 (2015), 대한암학회[DOI]
- Yoo SW, "Validity of Korean version of the mini-international neuropsychiatric interview", Anxiety Mood, 2, pp.50~55 (2006)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders, 4th ed" (2000), American Psychiatric Publishing
- Oh SM, "A study on the standardization of the hospital anxiety and depression scale for Koreans: a comparison of normal, depressed and anxious groups", J Korean Neuropsychiatr Assoc, 38, pp.289~296 (1999)
- Han C, "Validation of the Patient Health Questionnaire-9 Korean version in the elderly population: the Ansan Geriatric study", Compr Psychiatry, 49, pp.218~223 (2008)[DOI]
- Yun YH, "Validation of the Korean version of the EORTC QLQ-C30", Qual Life Res, 13, pp.863~868 (2004)[DOI]
- Cho MJ, "Lifetime and 12-month prevalence of DSM-IV psychiatric disorders among Korean adults", J Nerv Ment Dis, 195, pp.203~210 (2007)[DOI]
- Derogatis LR, "The prevalence of psychiatric disorders among cancer patients", JAMA, 249, pp.751~757 (1983)[DOI]
- Brintzenhofe-Szoc KM, "Mixed anxiety", depression symptoms in a large cancer cohort: prevalence by cancer type, 2009, pp.50, 383~391
- Yu H, "Depression and survival in Chinese patients with gastric cancer: a prospective study", Asian Pac J Cancer Prev, 13, pp.391~394 (2012)[DOI]
- Annunziata MA, "Does the information level of cancer patients correlate with quality of life? A prospective study", Tumori, 84, pp.619~623 (1998)[DOI]
- Grassi L, "Psychosocial problems secondary to cancer: an Italian multicentre survey of consultation-liaison psychiatry in oncology. Italian Consultation-Liaison Group", Eur J Cancer, 36, pp.579~585 (2000)[DOI]
- McCartney CF, "Effect of a psychiatric liaison program on consultation rates and on detection of minor psychiatric disorders in cancer patients", Am J Psychiatry, 146, pp.898~901 (1989)[DOI]
- Wilson KG, "Depression and anxiety disorders in palliative cancer care", J Pain Symptom Manage, 33, pp.118~129 (2007)[DOI]