The Efficacy of a Home-Based, Augmented Reality Dual-Task Platform for Cognitive-Motor Training in Elderly Patients: A Pilot Observational Study
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective This study introduces a novel home-based dual-task platform incorporating augmented reality (AR), COGNIMO, aimed at simultaneously enhancing cognition and physical abilities. The purpose of this study was to assess the effectiveness of this intervention in enhancing cognitive and physical abilities in elderly individuals with subjective cognitive decline, mild cognitive impairment (MCI), and mild Alzheimer’s dementia.Methods A 12-week observational study enrolled 57 participants aged 60–85 years. Primary outcomes included changes in cognitive scores (Korean Mini-Mental State Examination, 2nd edition [K-MMSE-2] and Korean-Montreal Cognitive Assessment [K-MoCA]), while secondary outcomes measured physical parameters and depression scores between baseline and week 12 in the active and the control groups.Results Of 57 participants, 49 completed the study. The active group (≥12 sessions) exhibited significant improvement in K-MoCA compared to the control group (<12 sessions) (p=0.004), while K-MMSE-2 score changes showed no significant difference (p=0.579). Positive correlations between training sessions and K-MoCA changes were observed (r=0.31, p=0.038), emphasizing a dose-response relationship. Subgroup analyses revealed a distinction in cognitive changes, particularly in the MCI group.Conclusion The COGNIMO platform showed positive effects on cognitive function in MCI patients, suggesting potential benefits for this population. The study highlights the potential of AR-integrated home-based interventions for cognitive enhancement in elderly individuals, underlining the need for further trials in the future.
Abstract
Objective This study introduces a novel home-based dual-task platform incorporating augmented reality (AR), COGNIMO, aimed at simultaneously enhancing cognition and physical abilities. The purpose of this study was to assess the effectiveness of this intervention in enhancing cognitive and physical abilities in elderly individuals with subjective cognitive decline, mild cognitive impairment (MCI), and mild Alzheimer’s dementia.Methods A 12-week observational study enrolled 57 participants aged 60–85 years. Primary outcomes included changes in cognitive scores (Korean Mini-Mental State Examination, 2nd edition [K-MMSE-2] and Korean-Montreal Cognitive Assessment [K-MoCA]), while secondary outcomes measured physical parameters and depression scores between baseline and week 12 in the active and the control groups.Results Of 57 participants, 49 completed the study. The active group (≥12 sessions) exhibited significant improvement in K-MoCA compared to the control group (<12 sessions) (p=0.004), while K-MMSE-2 score changes showed no significant difference (p=0.579). Positive correlations between training sessions and K-MoCA changes were observed (r=0.31, p=0.038), emphasizing a dose-response relationship. Subgroup analyses revealed a distinction in cognitive changes, particularly in the MCI group.Conclusion The COGNIMO platform showed positive effects on cognitive function in MCI patients, suggesting potential benefits for this population. The study highlights the potential of AR-integrated home-based interventions for cognitive enhancement in elderly individuals, underlining the need for further trials in the future.
참고문헌 (58)
- "Korean dementia observatory 2020. 2021"[URL]
- "Korean dementia ob servatory 2021. 2022"[URL]
- Livingston G, "Dementia prevention, intervention, and care", Lancet, 390, pp.2673~2734 (2017)
- Sikkes SAM, "Toward a theory-based specification of non-pharmacological treatments in aging and dementia : focused reviews and methodologi cal recommendations", Alzheimers Dement, 17, pp.255~270 (2021)
- Bhome R, "Interventions for subjec tive cognitive decline : systematic review and meta-analysis", BMJ Open, 8, pp.e021610~ (2018)
- Smart CM, "Non-pharmacologic interventions for older adults with subjective cognitive decline : systematic review, meta-analysis, and preliminary recommendations", Neuropsychol Rev, 27, pp.245~257 (2017)
- Karssemeijer EGA, "Positive effects of combined cognitive and physi cal exercise training on cognitive function in older adults with mild cognitive impairment or dementia : a meta-analysis", Ageing Res Rev, 40, pp.75~83 (2017)
- Zhu X, "The more the better? A meta-analysis on effects of combined cognitive and physical intervention on cogni tion in healthy older adults", Ageing Res Rev, 31, pp.67~79 (2016)
- Mancioppi G, "The use of motor and cog nitive dual-task quantitative assessment on subjects with mild cognitive impairment : a systematic review", Mech Ageing Dev, 193, pp.111393~ (2021)
- Choi H, "Coronavirus disease 2019 and dementia : the survey for dementia patients in COVID-19crisis", Dement Neurocogn Disord, 20, pp.16~17 (2021)
- Jessen F, "A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease", Alzheimers Dement, 10, pp.844~852 (2014)
- Winblad B, "Mild cognitive impairment--beyond controversies, towards a consensus : report of the international working group on mild cogni tive impairment", J Intern Med, 256, pp.240~246 (2004)
- McKhann G, "Clinical diagnosis of Alzheimer’s disease : report of the NINCDS ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease", Neurology, 34, pp.939~944 (1984)
- Jessen F, "The characterisation of subjective cognitive decline", Lancet Neurol, 19, pp.271~278 (2020)
- Ryu HJ, "The Seoul neuropsychological screening battery(SNSB)for comprehensive neuropsychological assessment", Dement Neurocogn Disord, 22, pp.1~15 (2023)
- Choi SH, "Validation of the literacy independent cognitive assessment", Int Psychogeriatr, 23, pp.593~601 (2011)
- Kang Y, "Korean Dementia Association. In : Korean Mini Mental State Examination, 2nd Edition(K-MMSE-2)" (2020), Hakjisa
- Morris JC, "Clinical dementia rating : a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type", Int Psychogeriatr, 9(Suppl 1), pp.173~176 (1997)
- Lee JI, "Effects of the home-based exercise program with an augmented reality system on balance in patients with stroke : a randomized controlled trial", Disabil Rehabil, 45, pp.1705~1712 (2023)
- "The validity of the Korean-Montreal Cognitive Assessment (K-MoCA) as a screening test for both MCI and VCI"[URL]
- Jung HY, "Reliability test of Korean version of Berg Balance Scale", Ann Rehabil Med, 30, pp.611~618 (2006)
- Park SW, "A study on the standardiza tion of the 6-minute walking test for elderly Koreans", Medico Legal Update, 20, pp.2085~2089 (2020)
- ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories, "ATS statement : guidelines for the six-minute walk test", Am J Respir Crit Care Med, 166, pp.111~117 (2002)
- Melo TA, "The f ive times sit-to-stand test : safety and reliability with older intensive care unit patients at discharge", Rev Bras Ter Intensiva, 31, pp.27~33 (2019)
- Bae JN, "Development of the Korean version of the geriatric depression scale and its short form among elderly psychiatric patients", J Psychosom Res, 57, pp.297~305 (2004)
- Herrmann N, "A validation study of the geriatric depression scale short form", Int J Geriatr Psychiatry, 11, pp.457~460 (1996)
- Enright PL, "The six-minute walk test", Respir Care, 48, pp.783~785 (2003)
- Petersen RC, "Mild cognitive impairment", Continuum(Minneap Minn), 22, pp.404~418 (2016)
- Xue D, "Combined exercise and cognitive in terventions for adults with mild cognitive impairment and dementia : a systematic review and network meta-analysis", Int J Nurs Stud, 147, pp.104592~ (2023)
- Hu M, "Effects of computer ised cognitive training on cognitive impairment : a meta-analysis", J Neurol, 268, pp.1680~1688 (2021)
- Hill NT, "Computerized cognitive training in older adults with mild cognitive impairment or dementia : a systematic review and meta-anal ysis", Am J Psychiatry, 174, pp.329~340 (2017)
- Meng Q, "The effect of combined cognitive intervention and physical exercise on cognitive function in older adults with mild cognitive impairment : a meta-anal ysis of randomized controlled trials", Aging Clin Exp Res, 34, pp.261276~ (2022)
- Yang C, "Effectiveness of combined cognitive and physical interventions to enhance functioning in older adults with mild cognitive impairment : a systematic review of randomized controlled trials", Gerontologist, 60, pp.633~642 (2020)
- Han K, "Effects of combined cognitive and physical intervention on enhancing cognition in older adults with and without mild cognitive impairment : a systematic review and meta analysis", Front Aging Neurosci, 14, pp.878025~ (2022)
- Law LL, "Effects of combined cognitive and exercise interventions on cognition in older adults with and with out cognitive impairment : a systematic review", Ageing Res Rev, 15, pp.61~75 (2014)
- Lee BT, "Neural basis involved in the interference effects during dual task : interaction between calculation and memory retrieval", Korean J Cogn Sci, 18, pp.159~178 (2007)
- Erickson KI, "Training-induced functional activation changes in dual-task processing : an FMRI study", Cereb Cortex, 17, pp.192~204 (2007)
- Beishon L, "Neuroimaging outcomes in studies of cognitive training in mild cognitive impairment and early Alzheimer’s disease : a system atic review", Curr Alzheimer Res, 17, pp.472~486 (2020)
- Damirchi A, "Mental training enhances cognitive function and BDNF more than either physical or combined training in elderly women with MCI : a small-scale study", Am J Alzheimers Dis Other Demen, 33, pp.20~29 (2018)
- Anderson-Hanley C, "The aerobic and cognitive exercise study(ACES)for community-dwelling older adults with or at-risk for mild cognitive impairment(MCI) : neuropsychological, neurobiological and neuroimaging outcomes of a randomized clinical trial", Front Aging Neurosci, 10, pp.76~ (2018)
- Styliadis C, "Neuroplastic effects of combined computerized physical and cog nitive training in elderly individuals at risk for dementia : an eLORETA controlled study on resting states", Neural Plast, 2015, pp.172192~ (2015)
- Nelson ME, "Physical activity and public health in older adults : recommendation from the American College of Sports Medicine and the American Heart Association", Med Sci Sports Exerc, 39, pp.1435~1445 (2007)
- Farhani F, "Ef fects of aerobic training on brain plasticity in patients with mild cogni tive impairment : a systematic review of randomized controlled trials", Brain Sci, 12, pp.732~ (2022)
- Iraniparast M, "Cog nitive reserve and mild cognitive impairment : predictors and rates of reversion to intact cognition vs progression to dementia", Neurology, 98, pp.e1114~e1123 (2022)
- Nelson ME, "Cognitive reserve, Alzheim er’s neuropathology, and risk of dementia : a systematic review and meta-analysis", Neuropsychol Rev, 31, pp.233~250 (2021)
- Zokaei N, "Cognitive training in the elderly : bottlenecks and new avenues", J Cogn Neurosci, 29, pp.1473~1482 (2017)
- Kueider AM, "Computerized cogni tive training with older adults : a systematic review", PLoS One, 7, pp.e40588~ (2012)
- Lee HK, "Home-based, adaptive cognitive training for cognitively normal older adults : initial efficacy trial", J Gerontol B Psychol Sci Soc Sci, 75, pp.1144~1154 (2020)
- Baik JS, "Effects of home-based computerized cognitive training in community-dwelling adults with mild cognitive impairment", IEEE J Transl Eng Health Med, 12, pp.97~105 (2023)
- Lim EH, "Effects of home based serious game training(Brain TalkTM)in the elderly with mild cognitive impairment : randomized, a single-blind, controlled tri al", Brain Neurorehabil, 16, pp.e4~ (2023)
- Hwang HF, "Effects of home-based computerized cognitive training and tai chi exercise on cognitive functions in older adults with mild cognitive impairment", Aging Ment Health, 27, pp.2170~2178 (2023)
- Park J, "Effect of 12week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment", Clin Interv Aging, 14, pp.1167~1175 (2019)
- D’Cunha NM, "A mini-review of virtual reality-based interven tions to promote well-being for people living with dementia and mild cognitive impairment", Gerontology, 65, pp.430~440 (2019)
- Iachini T, "T he experience of virtual reality : are individual differences in mental imagery associated with sense of presence?", Cogn Process, 20, pp.291298~ (2019)
- Mesa-Gresa P, "Effec tiveness of virtual reality for children and adolescents with autism spec trum disorder : an evidence-based systematic review", Sensors(Basel), 18, pp.2486~ (2018)
- Mubin O, "Exoskeletons with virtual reality, augmented reality, and gamification for stroke patients› rehabilitation : systematic review", JMIR Rehabil Assist Technol, 6, pp.e12010~ (2019)
- Zuschnegg J, "Computerized cognitive interventions for preventing dementia in people with mild cognitive impairment : a systematic review with meta-analyses", Alzheimers Dement, 18(suppl 1), pp.e062090~ (2022)
- Rohrbach N, "An augmented reality approach for ADL support in Alzheim er’s disease : a crossover trial", J Neuroeng Rehabil, 16, pp.66~ (2019)
