Effect of Tablet-based Cognitive Intervention on Cognition in Patients With Mild Cognitive Impairment: A Pilot Study
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background and Purpose: Growing evidence has shown that cognitive interventions can mitigate cognitive decline in patients with mild cognitive impairment (MCI). However, most previous cognitive interventions have been group-based programs. Due to their intrinsic limitations, group-based programs are not widely used in clinical practice. Therefore, we have developed a tablet-based cognitive intervention program. This preliminary study investigated the feasibility and effects of a 12-week structured tablet-based program on cognitive function in patients with MCI. Methods: We performed a single-arm study on 24 patients with MCI. The participants underwent a tablet-based cognitive intervention program 5 times a week over a 12-week period. The primary outcome was changes in cognitive function, measured using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K). Outcomes were evaluated at baseline, within two weeks of the last program (post-intervention), and at the six-month follow-up session. Results: The completion rate of the tablet-based program was 83.3% in patients with MCI. The program improved cognitive function based on the CERAD-K total score (p=0.026), which was maintained for at least three months (p=0.004). There was also an improvement in the depression scale score (p=0.002), which persisted for three months (p=0.027). Conclusions: Our 12-week structured tablet-based program is feasible for patients with MCI. Furthermore, although further studies with a double-arm design are required, the program appears to be an effective strategy to prevent cognitive decline in patients with MCI.
Abstract
Background and Purpose: Growing evidence has shown that cognitive interventions can mitigate cognitive decline in patients with mild cognitive impairment (MCI). However, most previous cognitive interventions have been group-based programs. Due to their intrinsic limitations, group-based programs are not widely used in clinical practice. Therefore, we have developed a tablet-based cognitive intervention program. This preliminary study investigated the feasibility and effects of a 12-week structured tablet-based program on cognitive function in patients with MCI. Methods: We performed a single-arm study on 24 patients with MCI. The participants underwent a tablet-based cognitive intervention program 5 times a week over a 12-week period. The primary outcome was changes in cognitive function, measured using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K). Outcomes were evaluated at baseline, within two weeks of the last program (post-intervention), and at the six-month follow-up session. Results: The completion rate of the tablet-based program was 83.3% in patients with MCI. The program improved cognitive function based on the CERAD-K total score (p=0.026), which was maintained for at least three months (p=0.004). There was also an improvement in the depression scale score (p=0.002), which persisted for three months (p=0.027). Conclusions: Our 12-week structured tablet-based program is feasible for patients with MCI. Furthermore, although further studies with a double-arm design are required, the program appears to be an effective strategy to prevent cognitive decline in patients with MCI.
참고문헌 (25)
- Petersen RC, "Mild cognitive impairment : ten years later", Arch Neurol, 66, pp.1447~1455 (2009)
- Sherman DS, "The efficacy of cognitive intervention in mild cognitive impairment(MCI) : a meta-analysis of outcomes on neuropsychological measures", Neuropsychol Rev, 27, pp.440~484 (2017)
- Jeong JH, "Group-and home-based cognitive intervention for patients with mild cognitive impairment : a randomized controlled trial", Psychother Psychosom, 85, pp.198~207 (2016)
- Butler M, "Does cognitive training prevent cognitive decline? : a systematic review", Ann Intern Med, 168, pp.63~68 (2018)
- Mourao RJ, "Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment : systematic review and meta-analysis", Int J Geriatr Psychiatry, 31, pp.905~911 (2016)
- Bingham KS, "Management of late-life depression in the context of cognitive impairment : a review of the recent literature", Curr Psychiatry Rep, 21, pp.74~ (2019)
- Dudas R, "Antidepressants for treating depression in dementia", Cochrane Database Syst Rev, 8, pp.CD003944~ (2018)
- Chae HJ, "Effectiveness of online-based cognitive intervention in community-dwelling older adults with cognitive dysfunction : a systematic review and meta-analysis", Int J Geriatr Psychiatry, 38, pp.e5853~ (2023)
- Xue B, "The effect of a game training intervention on cognitive functioning and depression symptoms in the elderly with mild cognitive impairment : a randomized controlled trial", Int J Methods Psychiatr Res, 30, pp.e1887~ (2021)
- Zucchella C, "The multidisciplinary approach to Alzheimer’s disease and dementia. a narrative review of non-pharmacological treatment", Front Neurol, 9, pp.1058~ (2018)
- Lim Eun Hee, "Effects of Home Based Serious Game Training (Brain Talk™) in the Elderly With Mild Cognitive Impairment: Randomized, a Single-Blind, Controlled Trial", 뇌신경재활, 16(1), pp.1~12 (2023), 대한뇌신경재활학회[DOI]
- Zhang H, "Effect of computerised cognitive training on cognitive outcomes in mild cognitive impairment : a systematic review and meta-analysis", BMJ Open, 9, pp.e027062~ (2019)
- Li R, "Effectiveness of computerized cognitive training in delaying cognitive function decline in people with mild cognitive impairment : systematic review and meta-analysis", J Med Internet Res, 24, pp.e38624~ (2022)
- Zuschnegg J, "Effectiveness of computer-based interventions for community-dwelling people with cognitive decline : a systematic review with meta-analyses", BMC Geriatr, 23, pp.229~ (2023)
- Lee JH, "Development of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet(CERAD-K) : clinical and neuropsychological assessment batteries", J Gerontol B Psychol Sci Soc Sci, 57, pp.47~53 (2002)
- Petersen RC, "Clinical practice. Mild cognitive impairment", N Engl J Med, 364, pp.2227~2234 (2011)
- THK5351 PET Imaging in Patients with Mild Cognitive Impairment, "Journal of Clinical Neurology", 2020, 202~214, pp.대한신경과학회
- Han C, "An adaptation of the Korean mini-mental state examination(K-MMSE)in elderly Koreans : demographic influence and population-based norms(the AGE study)", Arch Gerontol Geriatr, 47, pp.302~310 (2008)
- Bae JN, "Development of the Korean version of the Geriatric Depression Scale and its short form among elderly psychiatric patients", J Psychosom Res, 57, pp.297~305 (2004)
- Jung YH, "Frontal-executive dysfunction affects dementia conversion in patients with amnestic mild cognitive impairment", Sci Rep, 10, pp.772~ (2020)
- Jung AR, "Cognitive intervention using information and communication technology for older adults with mild cognitive impairment : a systematic review and meta-analysis", Int J Environ Res Public Health, 18, pp.11535~ (2021)
- Burton RL, "Telehealth rehabilitation for cognitive impairment : randomized controlled feasibility trial", JMIR Res Protoc, 7, pp.e43~ (2018)
- Simon SS, "Cognitive intervention in amnestic mild cognitive impairment : a systematic review", Neurosci Biobehav Rev, 36, pp.1163~1178 (2012)
- Jean L, "Cognitive intervention programs for individuals with mild cognitive impairment : systematic review of the literature", Am J Geriatr Psychiatry, 18, pp.281~296 (2010)
- Rozzini L, "Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors", Int J Geriatr Psychiatry, 22, pp.356~360 (2007)