안지오텐신 전환 효소 유전자 다형성과 운동내열성의 관련성
Association between Angiotensin converting enzyme gene polymorphism and Exercise heat tolerance
0
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
박계순, 김경배, 전태원. 안지오텐신 전환 효소 유전자 다형성과 운동내열성의 관련성. 운동과학, 제15권 제1호, 35-42, 2006. 건강한 성인에게 있어서 내열성의 차이는 성별, 유산소성 체력, 인체측정 변인 등에 의해 발생하지만, 이러한 표현형적인 요인들의 영향을 보정한 후에도 내열성의 개인차는 여전히 존재한다고 보고되어 왔기 때문에(Havenith, 1997), Heled 등(2004)은 이에 대한 대안으로 유전적인 요인, 즉 안지오텐신 전환효소의 유전자 다형성과 같은 요인이 운동내열성의 개인차와 관련된다는 것을 연구하여 발표하였다. 따라서 본 연구의 목적은, 고온다습한 한국적 서열기후 조건(35℃, 70% RH)에서 1시간 동안의 5km/h 걷기 운동시, ACE 유전자형 비율이 서구인과는 다른, 건강한 20대 남성을 대상으로 ACE 유전자 다형성이 운동내열성에 미치는 영향을 알아보는 것이다. 연구대상은 S대학교 남학생 45명(22.5±1.7세)이었으며, ACE 유전자는 II형과 ID형이 각각 17명씩이었고 DD형이 11명이었다. ACE 유전자형에 따라 최대산소섭취량에 유의한 차이가 나타나지 않았으며, 운동내열성도 유의한 차이가 나타나지 않았다. 유산소성 체력 수준을 보정한 후, ACE 유전자형에 따라 발한개시시간에서만 유의한 차이가 나타났다(F=6.254, p=.006). 결론적으로, 이러한 결과는, 이는 열 자극의 영향이 적고 운동시간이 다소 짧았기 때문이라고 할 수 있다.
Abstract
Park, K.S., Kim, K.B., Jun, T.W. Association between Angiotensin converting enzyme gene polymorphism and Exercise heat tolerance. Exercise Science, 15(1): 35-42, 2006. The variability of heat tolerance in young healthy humans has been known to be related gender, physical aerobic fitness, and anthropometric measurements. But, even after adjustment of these phenotypic fators, individual differences in heat-stress response still exist(Havenith, 1997). Heled et al.(2004) directly researched the possible relation between genotype characteristic and heat tolerance. They analyzed the association between different ACE genotypes with the variability in exercise heat-stress response in humans. The purpose of this study was to test the effects of ACE genotype on exercise(1H, treadmill walking, 5km/h) heat tolerance in hot environment(35℃, 70% RH). The subjects were 45 healthy mans (22.5±1.7 yrs) in university students: ACE gene II type=17, ID type=17, DD type=11. There were no significant difference of exercise heat tolerance among the ACE genotypes. Even though after regulation of the level of maximal oxygen uptake, the results were the same except for the first running time with sweat. Only the first running time with sweat was significant difference to ACE genotypes (F=6.254, p=.006). In conclusions, these results were likely caused that the temperature and the time of exercise was not enough to influence the heat-stress response.
참고문헌 (43)
- 길재호, "운동선수의 ACE 유전자 다형성과 심폐지구력", 한국운동영양학회지, 6(2), pp.77~84 (2002)
- 김선호, "안지오텐신 전환효소 유전자의 다형성이 복합훈련과 훈련중지에 따른 체력변화에 미치는 영향", 한국체육학회지, 42(4), pp.591~600 (2003)
- 남문석, "인슐린비의존형 당뇨병 환자에서 미세 및 대혈관 합병증에 따른 안지오텐신Ⅰ전환효소 유전자의 다형성", 당뇨병, 21(4), pp.397~405 (1997)
- 오지영, "인슐린비의존형 당뇨병 환자의 여성 직계자손에서 안지오텐신 전환효소 유전자 다형성과 인슐린 감수성 및 경동맥 내막중막 두께 사이의 관련성", 당뇨병, 23(6), pp.831~842 (1999)
- 이순원, "의복과 환경" (2002), 서울: 한국방송통신대학교출판부
- 조재혁, "안지오텐신 전환효소 유전자 다형성에 따른 최대운동 후의 혈역학적 변화", 한국체육학회지, 42(6), pp.857~867 (2003)
- 최석준, "복합훈련이 안지오텐신 전환효소 유전자 다형성에 따라 체력에 미치는 관련성", 체육과학연구, 13(1), pp.1~16 (2002)
- 최용어, "엘리트 육상선수의 ACE Gene과 심폐지구력과의 관계", 한국체육학회 국제학술대회 발표 (2000)
- 한성철, "엘리트 유도선수의 ACE, Apo E 유전자형과 심폐지구력, 혈중지질과의 상관관계", 한국체육학회지, 41(2), pp.689~700 (2002)
- ACSM, "ACSM's Guidelines for Exercise Testing and Prescription(7th ed.)" (2006), Philadelphia.: Lippincott Williams & Wilkins
- Araki T, "Effect of physical training on exercise- induced sweating in women", J Appl Physiol Respirat Environ Exercise Physiol, 51(6), pp.1526~1532 (1981)
- Armstrong L.E, "Response to moderate and low sodium diets during exercise acclimation", Int J Sport Nutr, 3(2), pp.207~221 (1993)
- Benson A, "Criteria for maximal oxygen uptake in collegiate subject(Supplement)", Med Sci Sports Exerc, 37(5), pp.97~ (2005)
- Burton A.C, "Human calorimetry. Ⅱ. The average temperature of the tissues of the body", J Nutr, 9, pp.261~280 (1935)
- Epstein, Y, "Exertional heat stroke: a case series", Med Sci Sports Exerc, 31, pp.224~228 (1999)
- Frank, A, "The cumulative heat strain index―a novel approach to assess the physiological strain induced by exercise-heat stress", Eur J Appl Physiol, 84, pp.527~532 (2001)
- Fujisawa T, "Angiotensin Ⅰ converting enzyme gene polymorphism is associated with myocardial infraction, but not with retinopathy or nephropathy in NIDDM", Diabetes Care, 78, pp.983~985 (1995)
- Furrukh, S. M, "Renin-angiotensin system: Genes to besides", Am Heart J., 134, pp.541~546 (1997)
- Gayagay, G, "Elite endurance athletes, and the ACE I allele-the role of genes in athletic performance", Hum Genet, 103, pp.48~50 (1998)
- Gisolfi, C, "Relations between physical training, acclimatization and heat tolerance", J Appl Physiol, 26, pp.530~534 (1969)
- Greenleaf J.E, "Drinking and Water balance during exercise and heat acclimation", J Appl Physiol Respirat Environ Exercise Physiol, 54(2), pp.414~419 (1983)
- Havenith, G, "Individual Heat Stress Response" (1997), Heidelberg: Springer-Verlag
- Havenith, G, "The relative influence of body characteristics on humid heat stress response", Eur J Appl Physiol Occup Physiol, 70, pp.270~279 (1995)
- Havenith, G., "The relative influence of physical fitness, acclimatization state, anthropometric measures, and gender on individual reaction to heat stress", Eur J Appl Physiol Occup Physiol, 61, pp.419~427 (1990)
- Heled, Y, "Human ACE I", D polymorphism is associated with individual differences in exercise heat tolerance, 2004, pp.97, 72~76
- Hori, S, "Studies on physiological responses in Okinawa to a hot environment", Jap J Physiol, 26, pp.235~244 (1976)
- Ishiko, T., "Two studies on the ICSPFT test battery, In Proceedings of the ACSPFT and the ICSPFT-1972" (1970), Israel, Wingate Institute
- Jones, A, "Human Performance: Role for the ACE Genotype?", pp.184~190 (2002), Exerc & Sport Sci Reviews
- Karjalainen, J, "Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes", J Am Coll Cardiol, 34, pp.494~499 (1999)
- King D.S, "Muscle metabolism during exercise in the heat in unacclimatized and acclimatized human", J Appl Physiol, 59, pp.1350~1354 (1985)
- Kosunen, K. J, "Plasma renin activity, angiotensin Ⅱ, and aldosterone during intense heat stress", J Appl Physiol, 41, pp.323~327 (1976)
- Lind A.R, "A physiological criterion for setting thermal environmental limits for everyday work", J Appl Physiol, 18, pp.61~66 (1963)
- McKinley, M. J, "The brain renin- angiotensin system: location, and physiological roles", Int J Biochem Cell Biol, 35, pp.901~918 (2003)
- Mitchell J.W, "Energy exchanges during exercise. In Nadel, E.R., Problems with temperature regulation during exercise" (1977), NY: Academic Press
- Montgomery, H. E, "Human gene for physical performance", Nature, 393(21), pp.221~ (1998)
- Nadel, E. R, "Circulatory and thermal regulations during exercise", Federation Proc, 39, pp.1491~1497 (1980)
- Nieman, D. C, "Exercise testing and prescription: A health-related approach" (2003), NY: McGraw-Hill
- Rankinen, T, "No association between the angiotensin converting enzyme ID polymorphism and elite endurance athlete status", J Appl Physiol, 88(5), pp.1571~1575 (2000)
- Rigat, B, "PCR detection of the insertion", deletion polymorphism of the human angiotensin converting enzyme gene, 1992, pp.20, 1433~
- Robinson S, "Circulatory adjustment of men in hot environments", Temperature: Its Measurement and control in Science and Industry, 3(3) (1963)
- Shapiro, Y, "Physiological responses of men, and women to humid and dry heat", J Appl Physiol, 52, pp.1~8 (1980)
- Sidman, R. D, "Exertional heat stroke in a young woman: gender differences in response to thermal stress", Acad Emerg Med, 2, pp.315~319 (1995)
- Wyndham, C. H, "Relation between VO2max and body temperature in hot humid air conditions", J Appl Physiol, 29, pp.45~50 (1970)