렙틴 수용체 유전자 변이를 가진 성인의 12주간 운동프로그램 수행 후 신체구성 및 혈중 지질변인 농도의 변화
Changes of blood concentration of lipid profiles and body composition after 12 weeks exercise program in Korean adults with mutation of leptin receptor gene
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안나영, 천우광, 신윤정, 김상현, 공경민, 고진호, 김기진. 렙틴 수용체 유전자 변이를 가진 성인의 12주간 운동프로그램 수행 후 신체구성 및 혈중 지질변인 농도의 변화. 운동과학, 제15권 제1호, 61-68. 2006. 이전의 연구에서는 비만과 관련된 렙틴 수용체 유전자의 다형성을 발견하였고, 본 연구에서는 렙틴 수용체의 유전자 변이를 가진 성인을 대상으로 일정기간 동안 운동프로그램을 수행하는 경우 현재 정상체중 및 비만상태에 따라서 신체구성 및 혈중 지질변인의 변화가 어떤 차이를 나타내는지 살펴보았다. 대상자는 렙틴 수용체 유전자의 변이를 가진 성인(비만그룹 n=47, 정상그룹 n=38)이었으며, 12주 동안 저항성 및 유산소 운동프로그램을 적용하였다. 운동 전후 신체구성은 체중, %fat, BMI, 피하지방 두께 및 신체둘레를 측정하였으며, 혈중지질 변인농도(TC, TG, HDL-C, LDL-C, FFA, 렙틴, 글루코스)를 분석하였으며, 렙틴 수용체 다형성은 PCR-RELP으로 분석하였다. %fat과 BMI는 12주 운동 후 유의하게(p<0.05) 감소하였으며, 피하지방두께는 상완이두근 및 대퇴를 제외한 대부분의 부위에서 두 그룹 모두 유의하게(p<0.05) 감소하였다. 신체둘레는 흉부, 복부, 엉덩이 및 대퇴 등에서 유의하게(p<0.05) 감소하였으며, TC 및 LDL-C농도는 두 그룹 모두 12주간의 운동프로그램 수행 후 유의하게 증가하였으며, 혈중 유리지방산 및 글루코스 농도는 유의하게(p<0.05) 감소하였다. 이상의 결과에서, 렙틴 수용체의 유전자 변이를 가진 정상체중 및 비만성인의 12주간의 운동프로그램 수행은 현재의 신체구성상 특성차이에 관계없이 신체구성 및 혈중지질변인농도 변화에 관해서 거의 동일하게 긍정적인 효과를 나타낸 것으로 간주되었다.
Abstract
Ahn, N.Y., Cheon, W.K., Shin, Y.J, Kim, S.H., Kong, K.M., Ko, J.H., Kim, K.J. Changes of blood concentration of lipid profiles and body composition after 12 weeks exercise program in Korean adults with mutation of leptin receptor gene. Exercise Science, 15(1): 61-68. 2006. Previous studies have been found for the polymorphism in the leptin receptor gene being involved in human obesity. We examined the changes of blood concentration of lipid profiles and body composition after exercise program in Korean adults with mutation of leptin receptor gene. Subjects were consisted of obese group(N=47) and non-obese group(N=38) in Korean adults with mutation of leptin receptor gene. Body composition was analyzed by body weight, %fat, and BMI. Additionally, skinfold thickness and body circumferences were measured for the analysis of the detailed physical characteristics. Leptin receptor polymorphism was detected by polymerase chain reaction with restriction fragment length polymorphism (PCR-RELP) assays. Percentage of body fat and BMI showed a significant(p<0.05) decrease after exercise program in non-obese and obese groups. All items of skinfold thickness except of biceps and thigh showed a significant(p<0.05) decrease after exercise program in both groups. Body circumferences of thorax, adomen, and hip, and thigh showed a significant(p<0.05) decrease after exercise program in both groups. Blood concentration of total cholesterol and LDL-C showed a significant(p<0.05) increase after exercise program in both groups, but blood concentration of FFA and glucose showed a significant(p<0.05) decrease after exercise program in both groups. In these results, we can suggested that obese and non-obese groups with with mutation of leptin receptor gene showed the similar positive responses to the obesity treatment with regular exercise despite of incident characteristics of body composition.
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