지구성 트레드밀 운동이 모체감염으로 유발된 뇌성마비 쥐의 운동기능, 정서기능 및 인지기능에 미치는 영향
Effect of endurance treadmill exercise on motor, emotional, and cognitive functions in developing rats with maternal infection -induced cerebral palsy
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본 연구는 지구성 트레이드밀 운동이 모체감염으로 유발된 뇌성마비 쥐의 운동기능, 정서기능 및 인지기능에 미치는 영향을 알아보는데 그 목적이 있다. 새끼 쥐에게 뇌성마비를 유발시키기 위하여 임신 15, 17, 20일에 내독소인 lipopolysaccharide (LPS)를 임신 쥐에게 0.15 mg/kg의 농도로 복강주사 하였다. 새끼 쥐들은 출생 5주차부터 저강도군(8 m/min)과 중강도군(14 m/min)으로 나누어, 매일 30분씩 주 5회의 트레드밀 운동을 4주간 실시하였다. 본 실험의 결과 임신 중 LPS 주입을 통하여 새끼 쥐들에게 뇌성마비 유발 시 운동기능과 인지기능이 저하된 반면, 불안장애 등의 정서기능에는 변화가 없었다. 또한 뇌성마비를 유발한 새끼 쥐들에게 저강도 및 중강도의 지구성 트레드밀 운동은 인지기능을 향상시켰다. 본 실험을 통하여 임신 중 모체감염에 의하여 유발되는 뇌성마비의 인지기능 저하에 지구성 트레드밀 운동이 치료 효과가 있음을 알 수 있었다.
Abstract
Effect of endurance treadmill exercise on motor, emotional, and cognitive functions in developing rats with maternal infection -induced cerebral palsy. Exercise Science. 18(3): 401-408, 2009. In the present study, we investigated the effect of endurance treadmill exercise on motor, emotional, and cognitive function in developing rats with maternal infection-induced cerebral palsy. In this study, the cerebral palsy was induced by intraperitoneal injection of lipopolysaccharide 0.15 mg/kg to the pregnant rats at gestation day 15, 17, and 20. The treadmill exercise load consisted of running at a speed of 8 m/min in the mild exercise group and 14 m/min in the moderate exercise group for 30 min once a day during 4 weeks. The present results showed that induction of cerebral palsy did not affect emotional function, however, it decreased motor and cognitive function. Endurance treadmill exercise ameliorated the disturbance of cognitive function induced cerebral palsy. These results suggest that endurance treadmill exercise may be used for the treatment of cerebral palsy to improve cognitive function.
참고문헌 (26)
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