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트레드밀 운동이 철의 축적과 미세아교세포 활성에 미치는 영향

The Effects of Treadmill Exercise on Iron Accumulation and Microglia Activation in the Brain of APP-C105 Transgenic Mice of Alzheimer’s Disease

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PURPOSE: This study is to investigate the effects of treadmill exercise on iron accumulation and microglial cell activity in the cerebral cortex of APP-C105 transgenic Alzheimer’s mice. METHODS: The transgenic mice and their comparative non-transgenic mice at 24 months of age were divided into 3 groups: NTC (Non-Tg-Con, n=7), TC (Tg-Con, n=7), TE (Tg-Exe, n=7). TE group ran on the treadmill (30 min/day, 5 day/week) for 8 weeks. RESULTS: The results show that treadmill exercise significantly improved spatial memory and cognitive function in TE group compared with TC group in Morris water-maze test and Passive avoidance test. In addition, TE group with treadmill exercise showed to decrease significantly in the accumulation level of iron, amyloid-beta protein, activated-microglia factor and pro-inflammation factor in comparison with TC group. anti-inflammation factor TE group was significantly increased than TC group. CONCLUSIONS: These results suggest that treadmill exercise has positive effects on cognitive function, iron accumulation level of iron and activated-microglia factor and it can act as a key role for clinical strategy in AD.

Abstract

PURPOSE: This study is to investigate the effects of treadmill exercise on iron accumulation and microglial cell activity in the cerebral cortex of APP-C105 transgenic Alzheimer’s mice. METHODS: The transgenic mice and their comparative non-transgenic mice at 24 months of age were divided into 3 groups: NTC (Non-Tg-Con, n=7), TC (Tg-Con, n=7), TE (Tg-Exe, n=7). TE group ran on the treadmill (30 min/day, 5 day/week) for 8 weeks. RESULTS: The results show that treadmill exercise significantly improved spatial memory and cognitive function in TE group compared with TC group in Morris water-maze test and Passive avoidance test. In addition, TE group with treadmill exercise showed to decrease significantly in the accumulation level of iron, amyloid-beta protein, activated-microglia factor and pro-inflammation factor in comparison with TC group. anti-inflammation factor TE group was significantly increased than TC group. CONCLUSIONS: These results suggest that treadmill exercise has positive effects on cognitive function, iron accumulation level of iron and activated-microglia factor and it can act as a key role for clinical strategy in AD.

참고문헌 (43)

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